其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Amodiaquin CAS Registry Number: 86-42-0 阿莫地喹

CAS Name: 4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol
Additional Names: 4-[(7-chloro-4-quinolyl)amino]-a-(diethylamino)-o-cresol; 7-chloro-4-(3-diethylaminomethyl-4-hydroxya...
Literature References: Prepd from 4,7-dichloroquinoline and 4-acetamido-a-diethylamino-o-cresol: Burckhalter et al., J. Am. Chem. Soc. 70, 1363 (1948); US 2474819; US 2474821 (1949 to Parke, Davis). Alternate synthesis from 2-aminomethyl-p-aminophenol and 4,7-dichloroquinoline: Natarajan, Lan, Arzneim.-Forsch. 22, 1230 (1972). Spectral study: J. Kracmar et al, Pharmazie 29, 773 (1974). HPLC determn in plasma, blood and urine: E. Pussard et al., J. Chromatogr. 374, 111 (1986). Comprehensive description: I. Ahmad et al., Anal. Profiles Drug Subs. 21, 43-73 (1992).

Parbendazole CAS Registry Number: 14255-87-9 帕苯达唑

CAS Name: (5-Butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester
Additional Names: methyl 5-butyl-2-benzimidazolecarbamate; 5-butyl-2-(carbomethoxyamino)benzimidazoleTrademarks: Helmatac (SK ...
Literature References: Prepd from 4-butyl-o-phenylenediamine and carbomethoxycyanamide: Actor et al., Nature 215, 321 (1967); GB 1123317 and Stedman; Actor, Pagano, US 3480642; US 3574845 (1968, 1969, 1971 all to SKF). Activity: Ostmann, Scheidy, Prog. Antimicrob. Anticancer Chemother., Proc. 6th Int. Congr. Chemother. 1, 159 (1970). Identification of metabolites: Dunn et al., J. Med. Chem. 16, 996 (1973).

Acrisorcin CAS Registry Number: 7527-91-5 吖啶琐辛

CAS Name: 4-Hexyl-1,3-benzenediol compd with 9-acridinamine (1:1)
Additional Names: 9-aminoacridine compd with 4-hexylresorcinol; 9-aminoacridinium 4-hexylresorcinolateTrademarks: Akrinol (Sche...
Literature References: Prepd from 9-aminoacridine and 4-hexylresorcinol: Seneca, Antibiot. Chemother. 11, 587 (1961).

Lithium Selenite CAS Registry Number: 15593-51-8 亚硒酸锂

CAS Name: Selenious acid dilithium salt
Percent Composition: Li 9.86%, O 34.08%, Se 56.06%
Literature References: Prepd from a soln of selenious acid in lithium hydroxide at 60°: Nilson, Bull. Soc. Chim. [2] 21, 253 (1874); ibid. [2] 23, 262 (1875).

Thallium Selenate CAS Registry Number: 7446-22-2

Additional Names: Thallous selenate
Percent Composition: O 11.60%, Se 14.31%, Tl 74.09%
Literature References: Prepd from a soln of thallous carbonate in selenic acid: Kuhlmann, Bull. Soc. Chim. [2] 1, 330 (1864).

Acetaldehyde Ammonia CAS Registry Number: 75-39-8 1-氨基乙醇

CAS Name: 1-Aminoethanol
Additional Names: a-aminoethyl alcohol; aldehyde ammonia
Percent Composition: C 39.33%, H 11.55%, N 22.93%, O 26.19%
Literature References: Prepd from acetaldehyde and ammonia: Aschan, Ber. 48, 874 (1915).

n-Butyl Acetate CAS Registry Number: 123-86-4 乙酸丁酯

CAS Name: Acetic acid butyl ester
Percent Composition: C 62.04%, H 10.41%, O 27.55%
Literature References: Prepd from acetic acid and butyl alcohol: Leyes, Othmer, Ind. Eng. Chem. 37, 968 (1945); Vogel, J. Chem. Soc. 1948, 624; Zettlemoyer et al., US 2644839 (1953 to FMC); Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 171-177. Toxicity data: H. F. Smyth et al., Arch. Ind. Hyg. Occup. Med. 10, 61 (1954).

Tribromo-tert-butyl Alcohol CAS Registry Number: 76-08-4 1,1,1-三溴-2-甲基丙烷-2-醇

CAS Name: 1,1,1-Tribromo-2-methyl-2-propanol
Additional Names: acetone-bromoform; brometone
Percent Composition: C 15.46%, H 2.27%, Br 77.12%, O 5.15%
Literature References: Prepd from acetone and bromoform in the presence of sodium or potassium hydroxide: Aldrich, J. Am. Chem. Soc. 33, 386 (1911); Viehe et al., Ber. 96, 426 (1963).

Bromoform CAS Registry Number: 75-25-2 三溴甲烷

CAS Name: Tribromomethane
Percent Composition: C 4.75%, H 0.40%, Br 94.85%
Literature References: Prepd from acetone and sodium hypobromite: Günther, Jahresber. Fortschr. Chem. 1887, 741 (Beilstein vol. 1, 68); Kergomard, Bull. Soc. Chim. Fr. 1961, 2360. Toxicity data: Kutob, Plaa, Toxicol. Appl. Pharmacol. 4, 354 (1962). Review of toxicology and human exposure: Toxicological Profile for Bromoform and Dibromochloromethane (PB2006-100001, 2005) 273 pp.

Isonitrosoacetone CAS Registry Number: 306-44-5 2-氧代丙醛肟

CAS Name: 2-Oxopropanal 1-oxime
Additional Names: pyruvaldoxime; propanone 1-oxime
Percent Composition: C 41.38%, H 5.79%, N 16.08%, O 36.75%
Literature References: Prepd from acetone by treatment with sodium nitrite in acetic acid at 0°: Küster, Z. Physiol. Chem. 155, 174 (1926); by the action of methyl nitrite on acetone in ether in the presence of HCl: Slater, J. Chem. Soc. 117, 589 (1920).