其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Propanocaine CAS Registry Number: 493-76-5 丙泮卡因

CAS Name: a-[2-(Diethylamino)ethyl]benzenemethanol benzoate (ester)
Additional Names: a-[2-(diethylamino)ethyl]benzyl alcohol benzoate; 3-diethylamino-1-phenylpropyl benzoate; a-(2-diethylamino...
Literature References: Prepd from acetophenone and trioxymethylene in the presence of diethylamine hydrochloride followed by catalytic hydrogenation and reaction with benzoyl chloride: Detrie, FR 1234701 (1960 to Clin-Byla), C.A. 55, 24682g (1961).

Atrolactic Acid CAS Registry Number: 515-30-0 苯乳酸水合物

CAS Name: a-Hydroxy-a-methylbenzeneacetic acid
Additional Names: a-methylmandelic acid; 2-phenyllactic acid; a-hydroxy-a-phenylpropionic acid; 2-hydroxy-2-phenylpropionic acid; 2-phenyl-2-hydro...
Literature References: Prepd from acetophenone cyanohydrin: McKenzie, Clough, J. Chem. Soc. 101, 393 (1912); Freudenberg et al., Ann. 501, 213 (1932); Eliel, Freeman, Org. Synth. coll. vol. IV, 58 (1963).

Methyl Acetylsalicylate CAS Registry Number: 580-02-9 乙酰水杨酸甲酯

CAS Name: 2-(Acetyloxy)benzoic acid methyl ester
Additional Names: acetylsalicylic acid methyl ester; methylaspirin
Trademarks: Methylrodin; Methylrhodine
Percent Composition: C 61.85%, H...
Literature References: Prepd from acetylsalicylic acid and diazomethane: Herzig, Tichatschek, Ber. 39, 1559 (1906); from methyl salicylate and acetic anhydride: Erdmann, J. Prakt. Chem. [2] 56, 154 (1897); Thorp, US 1255950 (1918).

b -Chloropropionitrile CAS Registry Number: 542-76-7 β-氯丙腈

CAS Name: 3-Chloropropanenitrile
Additional Names: 3-chloropropanonitrile
Percent Composition: C 40.25%, H 4.50%, Cl 39.60%, N 15.65%
Literature References: Prepd from acrylonitrile and hydrogen chloride or bromide: Moureu, Clarke, Bull. Soc. Chim. Fr. [4] 27, 905 (1920); Stewart, Clarke, J. Am. Chem. Soc. 69, 714 (1947); Shirley, Preparation of Organic Intermediates (Wiley, New York, 1951) p 82.

Acrylamide CAS Registry Number: 79-06-1 丙烯酰胺

CAS Name: 2-Propenamide
Percent Composition: C 50.69%, H 7.09%, N 19.71%, O 22.51%
Literature References: Prepd from acrylonitrile by treatment with H2SO4 or HCl: Bayer, Angew. Chem. 61, 240 (1949); Weisgerber, US 2535245 (1950 to Hercules). Reviews: Carpenter, Davis, J. Appl. Chem. 7, 671 (1957); C. E. Habermann in Kirk-Othmer Encyclopedia of Chemical Technology vol. 1 (John Wiley Sons, New York, 4th ed., 1991) pp 251-266. Toxicity: R. E. Peterson, N. K. Sheth, Toxicol. Appl. Pharmacol. 33, 142 (1975). Review of carcinogenic risk: IARC Monographs 60, 389-433 (1994). Identification in cooked carbohydrate-rich foods: E. Tareke et al., J. Agric. Food Chem. 50, 4998 (2002). Proposed formation from asparagine, q.v., during cooking: D. S. Mottram et al., Nature 419, 448 (2002); R. H. Stadler et al., ibid. 449.

Aluminum Palmitate CAS Registry Number: 555-35-1 三棕榈酸铝

CAS Name: Hexadecanoic acid aluminum salt
Additional Names: palmitic acid aluminum salt
Percent Composition: C 72.68%, H 11.82%, Al 3.40%, O 12.10%
Literature References: Prepd from AlCl3 and palmitic acid: Mehrotra, Rai, J. Indian Chem. Soc. 39, 1 (1962).

Allyl Iodide CAS Registry Number: 556-56-9 烯丙基碘

CAS Name: 3-Iodo-1-propene
Additional Names: 3-iodopropylene
Percent Composition: C 21.45%, H 3.00%, I 75.55%
Literature References: Prepd from allyl alcohol, methyl iodide, and triphenyl phosphite: Landauer, Rydon, J. Chem. Soc. 1953, 2224; Rydon, Landauer, GB 695468 (1953 to Nat. Res. Dev. Corp.).

Allyl Ethyl Ether CAS Registry Number: 557-31-3 烯丙基乙基醚

CAS Name: 3-Ethoxy-1-propene
Additional Names: ethyl allyl ether
Percent Composition: C 69.72%, H 11.70%, O 18.58%
Literature References: Prepd from allyl bromide and sodium alcoholate: Brühl, Ann. 200, 139 (1880).

Methenamine Allyl Iodide CAS Registry Number: 36895-62-2

Additional Names: Allyl iodide hexamine; allyl iodide hexamethylenetetramine; allyliodourotropine
Percent Composition: C 35.08%, H 5.56%, I 41.18%, N 18.18%
Literature References: Prepd from allyl iodide and methenamine: F. J. Welcher, Org. Anal. Reagents (Van Nostrand, New York, 1st ed., 1947) p 121; Hurd, Evans, Ind. Eng. Chem. Anal. Ed. 5, 16 (1933).

Diallylamine CAS Registry Number: 124-02-7 二烯丙基胺

CAS Name: N-2-Propenyl-2-propen-1-amine
Additional Names: di-2-propenylamine
Percent Composition: C 74.17%, H 11.41%, N 14.42%
Literature References: Prepd from allylamine and allyl bromide: Ladenburg, Ber. 14, 1879 (1881); from allylamine and allyl chloride: Liebermann, Hagen, Ber. 16, 1641 (1883); from diallylcyanamide by refluxing with dil H2SO4: Vliet, J. Am. Chem. Soc. 46, 1307 (1924); Org. Synth. coll. vol. I (2nd ed.,1941) p 201. Toxicity study: H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 23, 95 (1962).