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Oxymetazoline CAS Registry Number: 1491-59-4 羟甲唑啉

CAS Name: 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol
Additional Names: 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol; 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolineTrademarks: Navisin; Hazol; Rhinofrenol; Rhinolitan (3M Pharma); Sinerol; Nezeril (Draco)
Percent Composition: C 73.81%, H 9.29%, N 10.76%, O 6.14%

📌 参考资料/链接：
Literature References: Prepd from (4-tert-butyl-2,6-dimethyl-3-hydroxyphenyl)acetonitrile and ethylenediamine: Fruhstorfer, Mueller-Calgan, DE 1117588 (1961 to E. Merck), C.A. 57, 4674a (1962). Toxicity data: Hotovy et al., Arzneim.-Forsch. 11, 1016 (1961).

📄 详细内容

Properties: Crystals from benzene, mp 181-183°.
Melting point: mp 181-183°
Derivative Type: Hydrochloride
CAS Registry Number: 2315-02-8
Trademarks: Afrazine (Schering-Plough); Afrin (Schering-Plough); Iliadin (Meda); Nafrine; Nasivin (Merck KGaA); Oxilin (Allergan); Sinex (LaChartre)
Percent Composition: C 64.74%, H 8.49%, N 9.44%, O 5.39%, Cl 11.94%
Properties: Crystals, dec 300-303°. Freely sol in water, alcohol. Practically insol in ether, chloroform, benzene. LD50 orally in mice: 10 mg/kg (Hotovy).
Toxicity data: LD50 orally in mice: 10 mg/kg (Hotovy)
NOTE: Ingredient of
Drixin.
Therap-Cat: Adrenergic (vasoconstrictor); nasal decongestant.
Keywords: a-Adrenergic Agonist; Decongestant.
产品链接: 1491-59-4››

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