其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bialamicol CAS Registry Number: 493-75-4 比拉米可

CAS Name: 3,3'-Bis[(diethylamino)methyl]-5,5'-di-2-propenyl-[1,1'-biphenyl]-4,4'-diol
Additional Names: 5,5'-diallyl-a,a'-bis(diethylamino)-m,m'-bitolyl-4,4'-diol; 6,6'-diallyl-a,a'-bis(diethyl...
Literature References: Prepd by treating 2,2¢-diallyl-p,p¢-biphenol with diethylamine and formaldehyde: Burckhalter et al., J. Am. Chem. Soc. 68, 1894 (1946); Rawlins et al., US 2459338 (1949 to Parke, Davis).

Sulfaquinoxaline CAS Registry Number: 59-40-5 磺胺喹噁啉

CAS Name: 4-Amino-N-2-quinoxalinylbenzenesulfonamide
Additional Names: N1-(2-quinoxalinyl)sulfanilamide; 2-sulfanilamidoquinoxaline; N1-(2-quinoxalyl)sulfanilamide; sulfabenzpyrazineTrademarks:...
Literature References: Prepd by treating 2-aminoquinoxaline with acetylsulfanilyl chloride in the presence of pyridine and hydrolyzing the resulting acetyl deriv: Weijlard et al., J. Am. Chem. Soc. 66, 1957 (1944); Weijlard, Tishler, US 2404199 (1946 to Merck Co.). Anticoccidial spectrum: G. F. Mathis et al., Poult. Sci. 63, 1149 (1984). Evaluation of antibacterial and anticoccidial efficacy of mixture with trimethoprim: G. White, R. B. Williams, Vet. Rec. 113, 608 (1983); D. W. T. Piercy et al., ibid. 114, 60 (1984). Drug residue study in poultry muscle and liver: M. Patthy, J. Chromatogr. 275, 115 (1983). HPLC determn in rabbit plasma and urine: J. G. Eppel, J. J. Thiessen, J. Pharm. Sci. 73, 1635 (1984).

Amido-R-Acid CAS Registry Number: 92-28-4 3-氨基-2,7-萘二磺酸

CAS Name: 3-Amino-2,7-naphthalenedisulfonic acid
Additional Names: 2-naphthylamine-3,6-disulfonic acid
Percent Composition: C 39.60%, H 2.99%, N 4.62%, O 31.65%, S 21.14%
Literature References: Prepd by treating 2-hydroxy-3,6-naphthalenedisulfonic acid with ammonium sulfite and ammonium hydroxide: Petitcolas, Josué, Bull. Soc. Chim. Fr. 1952, 89.

Chloroxylenol CAS Registry Number: 88-04-0 4-氯-3,5-二甲基苯酚

CAS Name: 4-Chloro-3,5-dimethylphenol
Additional Names: p-chloro-m-xylenol; 4-chloro-3,5-xylenol; parachlorometaxylenol; 2-chloro-m-xylenol; 2-chloro-5-hydroxy-m-xylene; 2-chloro-5-hydroxy-1,3-...
Literature References: Prepd by treating 3,5-dimethylphenol with Cl2 or SO2Cl2: Lesser, Gad, Ber. 56, 974, 976 (1923); von Auwers et al., Chem. Zentralbl. 1924, II, 2267, C.A. 19, 2339 (1925); Gladden, Cocker, US 2350677 (1944).

Isocinchomeronic Acid CAS Registry Number: 100-26-5 吡啶-2,5-二羧酸

CAS Name: 2,5-Pyridinedicarboxylic acid
Percent Composition: C 50.31%, H 3.02%, N 8.38%, O 38.29%
Literature References: Prepd by treating 5-ethyl-2-picoline (aldehyde-collidine) with suitable oxidizing agents such as HNO3, KMnO4, or H2SeO3: Meyer, Staffen, Monatsh. Chem. 34, 517 (1913); Jordan, Ind. Eng. Chem. 44, 332 (1952); Kato, Bull. Chem. Soc. Jpn. 34, 636 (1961); by oxidation of 5-acetyl-2-methylpyridine: Binns, Swan, J. Chem. Soc. 1962, 2831; from the lutidine fraction of coal tar lutidine: Lukes et al., Collect. Czech. Chem. Commun. 26, 3044 (1961).

Nifuroxime CAS Registry Number: 6236-05-1 硝呋醛肟标准品

CAS Name: 5-Nitro-2-furancarboxaldehyde oxime
Additional Names: anti-5-nitro-2-furaldoxime
Trademarks: Micofur (Norwich)
Percent Composition: C 38.47%, H 2.58%, N 17.95%, O 41.00%
Literature References: Prepd by treating 5-nitrofurfural with hydroxylamine in alcohol: Ikeda, C.A. 50, 10701 (1956). Claimed in Stillman et al., US 2319481 (1943 to Norwich Pharmacal).

N-Bromoacetamide CAS Registry Number: 79-15-2 N-溴代乙酰胺

Additional Names: Acetobromamide
Percent Composition: C 17.41%, H 2.92%, Br 57.92%, N 10.15%, O 11.60%
Literature References: Prepd by treating a cooled (0-5°) soln of acetamide dissolved in bromine with ice cold aq 50% KOH, allowing to stand for 2-3 hr at 0-5°, treating with NaCl, and extracting with chloroform: Oliveto, Gerold, Org. Synth. 31, 17 (1951).

Ammonium Selenate CAS Registry Number: 7783-21-3

Percent Composition: H 4.50%, N 15.65%, O 35.75%, Se 44.10%
Literature References: Prepd by treating a soln of selenic acid with ammonia: Retgers, Z. Phys. Chem. 8, 36 (1891); King, J. Phys. Chem. 41, 797 (1937). Crystal structure: Gatlow, Acta Crystallogr. 15, 419 (1962).

Carboxymethylcellulose Sodium CAS Registry Number: 9004-32-4 羧甲基纤维素钠

CAS Name: Carboxymethyl ether cellulose sodium salt
Additional Names: sodium carboxymethylcellulose; sodium cellulose glycolate
Trademarks: Cethylose (Ascher); CMC (Stuart); Cel-O-Brandt; Gl...
Literature References: Prepd by treating alkali cellulose with sodium chloroacetate: Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 235-238. Review and bibliography: Ott, Cellulose and Cellulose Derivatives, New York, 1946 (2nd ed., 1955).

Methimazole CAS Registry Number: 60-56-0 甲巯咪唑

CAS Name: 1,3-Dihydro-1-methyl-2H-imidazole-2-thione
Additional Names: 1-methylimidazole-2-thiol; 1-methyl-2-mercaptoimidazole; mercazolyl; thiamazole
Trademarks: Basolan; Danantizol; Favist...
Literature References: Prepd by treating aminoacetaldehyde diethyl acetal with methyl isothiocyanate: Wohl, Marckwald, Ber. 22, 1354 (1889); from thiocyanic acid and N-substituted amino acetals: Jones et al., J. Am. Chem. Soc. 71, 4000 (1949). Metabolism: D. S. Sitar, D. P. Thornhill, J. Pharmacol. Exp. Ther. 184, 432 (1973). Comprehensive description: H. Y. Aboul-Enein, A. A. Al-Badr, Anal. Profiles Drug Subs. 8, 351-370 (1979). Review of pharmacology and clinical experience: D. S. Cooper, N. Engl. J. Med. 311, 1353-1362 (1984).