其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Methylene Iodide CAS Registry Number: 75-11-6 二碘甲烷

CAS Name: Diiodomethane
Percent Composition: C 4.48%, H 0.75%, I 94.76%
Literature References: Prepd by the reduction of iodoform with sodium arsenite: Adams, Marvel, Org. Synth. vol. 1, p 57 (1921). Also by heating iodoform with sodium acetate in alcohol: Bagnara, Eng. Min. J. Press 116, 51 (1923). Absorption spectrum: Lowry, Sass, J. Chem. Soc. 1926, 624; Stepanov, Acta Physicochim. URSS 20, 174 (1945).

m-Phenylenediamine CAS Registry Number: 108-45-2 间苯二胺

CAS Name: 1,3-Benzenediamine
Additional Names: m-diaminobenzene
Percent Composition: C 66.64%, H 7.46%, N 25.90%
Literature References: Prepd by the reduction of m-dinitrobenzene: Kuhn, US 2768209 (1956 to Ringwood); Faust, J. Prakt. Chem. 6, 14 (1958); Neilson et al., J. Chem. Soc. 1962, 371; Tallee, Peltier, Compt. Rend. 259, 400 (1964). Toxicity study: C. Burnett et al., J. Toxicol. Environ. Health 2, 657 (1977).

Nitrophenide CAS Registry Number: 537-91-7 3,3'-二硝基二苯二硫醚

CAS Name: Bis(3-nitrophenyl)disulfide
Additional Names: m,m'-dinitrodiphenyl disulfide; NP
Trademarks: Megasul (Am. Cyanamid)
Percent Composition: C 46.74%, H 2.62%, N 9.09%, O 20.76%, S ...
Literature References: Prepd by the reduction of m-nitrobenzenesulfonylchloride with hydriodic acid: Ekbom, Ber. 24, 336 (1891); Foss et al., J. Am. Chem. Soc. 60, 2729 (1938). Anticoccidial activity: Waletzky et al., Ann. N.Y. Acad. Sci. 52, 543 (1949).

p-Aminophenylacetic Acid CAS Registry Number: 1197-55-3 对氨基苯乙酸

CAS Name: 4-Aminobenzeneacetic acid
Additional Names: p-amino-a-toluic acid
Percent Composition: C 63.57%, H 6.00%, N 9.27%, O 21.17%
Literature References: Prepd by the reduction of p-nitrophenylacetic acid with hydrogen sulfide in the presence of ammonia: G. R. Robertson, Org. Synth. coll. vol. I, 52 (2nd ed., 1941).

Titanium Hydride CAS Registry Number: 7704-98-5 二氢化钛

Percent Composition: H 4.04%, Ti 95.96%
Literature References: Prepd by the reduction of titanium oxide with calcium hydride in the presence of hydrogen above 600°: Alexander, US 2427338 (1947).

Vanadium Trisulfate CAS Registry Number: 13701-70-7 硫酸钒(Ⅲ)

Percent Composition: O 49.22%, S 24.66%, V 26.12%
Literature References: Prepd by the reduction of V2O5 in sulfuric acid with elemental sulfur: Auger, Compt. Rend. 173, 306 (1921); Riveng, Bull. Soc. Chim. Fr. 4, 1697 (1937); Claunch, Jones, Inorg. Synth. 7, 92 (1963).

a -Aminoisobutyric Acid CAS Registry Number: 62-57-7 2-氨基异丁酸

CAS Name: 2-Methylalanine
Additional Names: 2-aminoisobutyric acid; 2-amino-2-methylpropanoic acid
Percent Composition: C 46.59%, H 8.80%, N 13.58%, O 31.03%
Literature References: Prepd by the treatment of acetone with hydrocyanic acid and then with alcoholic ammonia (Strecker synthesis): Tiemann, Friedländer, Ber. 14, 1970 (1881), see also p 1965; Marckwald et al., Ber. 24, 3283 (1891); Bailey, Randolph, Ber. 41, 2507 (1908); Clarke, Bean, Org. Synth. coll. vol. II, 29 (1943); or directly with ammonium cyanide: Gulewitsch, Ber. 33, 1900 (1900) or with a mixture of KCN and NH4Cl: Zelinsky, Stadnikow, Ber. 39, 1726 (1906); cf. Hellsing, Ber. 37, 1921 (1904); and subsequent hydrolysis of the nitrile formed. By heating dimethylhydantoin (obtained from acetone, hydrocyanic and cyanic acids) with concd HCl: Urech, Ann. 164, 268 (1872), cf. Heilpern, Monatsh. Chem. 17, 241 (1896).

Benzanilide CAS Registry Number: 93-98-1 N-苯甲酰替苯胺

CAS Name: N-Phenylbenzamide
Additional Names: N-benzoylaniline
Percent Composition: C 79.17%, H 5.62%, N 7.10%, O 8.11%
Literature References: Prepd by the treatment of aniline with benzoic acid: Hübner, Ann. 208, 291 (1881); Nägeli, Bull. Soc. Chim. [3] 11, 892 (1894); Webb, Org. Synth. 7, 6 (1927); coll. vol. I (2nd ed., 1941) p 82.

Stannous Pyrophosphate CAS Registry Number: 15578-26-4 焦磷酸亚锡

CAS Name: Diphosphoric acid tin(2+) salt (1:2)
Additional Names: ditin diphosphate; ditin pyrophosphate
Percent Composition: O 27.23%, P 15.06%, Sn 57.72%
Literature References: Prepd by thermal dehydration of stannous hydrogen phosphate: Jablczynski, Wieckowski, Z. Anorg. Allg. Chem. 152, 207 (1926); from Na2H2P2O7 and SnCl2: Klement, Haselbeck, Ber. 96, 1022 (1958); from pyrophosphoric acid and stannous chloride: Nelson, US 3401012 (1968 to Monsanto). Clinical application for labelling red blood cells: D. Ducasson et al., Br. J. Radiol. 49, 344 (1976). Chemical characterization of technetium complexes: J. Kroesbergen et al., Nucl. Med. Biol. 15, 209 (1988). Diagnostic application in bone scanning: N. S. Anderton et al., Am. J. Roentgenol. Radium Ther. Nucl. Med. 124, 625 (1975); in myocardial infarction: D. E. Jansen et al., Circulation 75, 611 (1987).

Ectylurea CAS Registry Number: 95-04-5 依克替脲

CAS Name: (Z)-N-(Aminocarbonyl)-2-ethyl-2-butenamide
Additional Names: (2-ethylcrotonoyl)urea; (a-ethylcrotonyl)urea; (a-ethylcrotonyl)carbamide
Trademarks: Astyn; Ektyl; Levanil (Upjohn); N...
Literature References: Prepd by treating (2-bromo-2-ethylbutyryl)urea with dil boiling NaOH: Newbery, J. Chem. Soc. 127, 295 (1925). Prepn from carbromal and isopropanol by refluxing with silver oxide: Fancher, US 2854379, US 2931832 (1958, 1960 to Miles Labs.). Pharmacology and toxicity: M. H. Pindell et al., Fed. Proc. 12, 357 (1953).