其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Diacetazotol CAS Registry Number: 83-63-6 N,N,-二乙酰邻氨基偶氮甲苯

CAS Name: N-Acetyl-N-[2-methyl-4-[(2-methylphenyl)azo]phenyl]acetamide
Additional Names: 4''-(o-tolylazo)-o-diacetotoluidide; diacetylaminoazotoluene; N,N-diacetyl-o-tolyazo-o-toluidine; 2,3'-d...
Literature References: Prepd by treating aminoazotoluene with acetic anhydride or with acetyl chloride in the presence of sodium acetate: DE 253884 (1912 to Kalle); Ettel, Hebky, Collect. Czech. Chem. Commun. 13, 161 (1948). Biological properties: Rerábek et al., C.A. 46, 7234i (1952). Allergenic properties: Jirasek et al., Cesk. Dermatol. 41, 38 (1966).

Chloroazodin CAS Registry Number: 502-98-7 氯脒佐定

CAS Name: N,N''-Dichlorodiazenedicarboximidamide
Additional Names: a,a'-azobis[chloroformamidine]; chlorazodin; dichloroazodicarbonamidine; azochloramide
Percent Composition: C 13.13%, H 2.2...
Literature References: Prepd by treating an AcOH-NaOAc soln of guanidine nitrate with sodium hypochlorite in the cold: Braz et al., Appl. Chem. USSR 17, 565 (1944), C.A. 40, 2267 (1946). Structure and uv spectra: Kumler, J. Am. Chem. Soc. 75, 3092 (1953).

Benzoin CAS Registry Number: 119-53-9 2-羟基-2-苯基苯乙酮

CAS Name: 2-Hydroxy-1,2-diphenylethanone
Additional Names: benzoylphenylcarbinol; a-hydroxy-a-phenylacetophenone; bitter-almond-oil camphor
Percent Composition: C 79.23%, H 5.70%, O 15.08%
Literature References: Prepd by treating an alcoholic soln of benzaldehyde with an alkali cyanide: Adams, Marvel, Org. Synth. vol. 1, p 33 (1921); coll. vol. I, 88; Arnold, Fuson, J. Am. Chem. Soc. 58, 1295 (1936); L. F. Fieser, Organic Experiments (D. C. Heath Co., Boston, 1964) pp 211-214.

Glycarsamide CAS Registry Number: 144-87-6 4-(羟基乙酰基氨基)苯胂酸

CAS Name: [4-[(Hydroxyacetyl)amino]phenyl]arsonic acid
Additional Names: N-glycoloylarsanilic acid; N-glycolylarsanilic acid; p-glycolylaminobenzenearsonic acid; p-glycolylaminophenylarsinic ac...
Literature References: Prepd by treating arsanilic acid with chloroacetyl chloride and NaOH: Streitwolf et al., DE 513210; GB 344532 (1929 to I. G. Farben).

Norvaline CAS Registry Number: 6600-40-4 L-正缬氨酸

CAS Name: 2-Aminovaleric acid
Additional Names: a-aminovaleric acid; 2-aminopentanoic acid
Percent Composition: C 51.26%, H 9.46%, N 11.96%, O 27.31%
Literature References: Prepd by treating butyraldehyde ammonia with HCN and HCl: Slimmer, Ber. 35, 404 (1902); from 2-acetylvaleric acid ethyl ester: Hamlin, Hartung, J. Biol. Chem. 145, 349 (1942); from acetamidomalonic acid diethyl ester: Archer, Albertson, US 2445817 (1948 to Winthrop-Stearns); from 1-nitrobutane: Stiles, Finkbeiner, J. Am. Chem. Soc. 85, 616 (1963); US 3055936 (1962 to Res. Corp.). Prepn of optically active forms: Abderhalden, Kurton, Fermentf. 4, 328; Chem. Zentralbl. 1921, III, 296.

Crotamiton CAS Registry Number: 483-63-6 克罗米通

CAS Name: N-Ethyl-N-(2-methylphenyl)-2-butenamide
Additional Names: N-ethyl-o-crotonotoluidide; crotonyl-N-ethyl-o-toluidine
Trademarks: Crotamitex (Troponwerke); Eurax (Novartis); Euraxil (...
Literature References: Prepd by treating crotonic acid o-toluidide with diethyl sulfate: CH 253472; CH 253473; GB 615137 (1949 to Geigy).

Nitranilic Acid CAS Registry Number: 479-22-1 2,5-二羟基-3,6-二硝基-1,4-苯醌

CAS Name: 2,5-Dihydroxy-3,6-dinitro-2,5-cyclohexadiene-1,4-dione
Additional Names: 2,5-dihydroxy-3,6-dinitro-p-benzoquinone; 2,5-dihydroxy-3,6-dinitroquinone
Percent Composition: C 31.32%, H...
Literature References: Prepd by treating hydroquinone diacetate with fuming nitric and concd sulfuric acids: Nietzki, Benckiser, Ber. 18, 499 (1885); Nietzki, Ber. 43, 3458 (1910); Meyer, Ber. 57, 326 (1924); Town, Biochem. J. 30, 1833 (1936).

Methoxyamine CAS Registry Number: 67-62-9 O-甲基羟胺

CAS Name: O-Methylhydroxylamine
Additional Names: methoxylamine; a-methylhydroxylamine; hydroxylamine methyl ether
Percent Composition: C 25.52%, H 10.71%, N 29.76%, O 34.00%
Literature References: Prepd by treating hydroxylamine disulfonic acid with methyl sulfate: Goldfarb, J. Am. Chem. Soc. 67, 1852 (1945). May also be prepd from hydroxyurethan. Use as reagent for carbonyl compounds: A. H. Blatt, J. Am. Chem. Soc. 61, 3494 (1939).

Aluminum Lithium Hydride CAS Registry Number: 16853-85-3 氢化铝锂

CAS Name: Lithium tetrahydroaluminate
Additional Names: lithium aluminum hydride; lithium aluminohydride; lithium alanate
Percent Composition: Al 71.10%, H 10.62%, Li 18.29%
Literature References: Prepd by treating lithium hydride with an ether soln of AlCl3: Finholt, et al., J. Am. Chem. Soc. 69, 1199 (1947). Crystal structure: Sklar, Post, Inorg. Chem. 6, 669 (1967). Review of chemistry: J. S. Pizey, Synthetic Reagents Vol. 1 (John Wiley, New York, 1974) pp 101-294.

Chloroacetic Anhydride CAS Registry Number: 541-88-8 氯乙酸酐

CAS Name: Chloroacetic acid anhydride
Additional Names: monochloroacetic acid anhydride; sym-dichloroacetic anhydride
Percent Composition: C 28.10%, H 2.36%, Cl 41.47%, O 28.07%
Literature References: Prepd by treating monochloroacetic acid in tetrahydrofuran with methoxyacetylene at 15° and distilling the mixture: Eglinton et al., J. Chem. Soc. 1954, 1860; by mixing monochloroacetic acid and HCN with 1,4-dioxane satd with HCl and fractionating the mixture: Krieble, Smellie, US 2390106 (1945); by heating chloroacetyl chloride with monochloroacetic acid in the presence of AlCl3: Strosacker, Schwegler, US 1713104 (1929 to Dow).