其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bis(1-naphthylmethyl)amine CAS Registry Number: 5798-49-2

CAS Name: N-(1-Naphthalenylmethyl)-1-naphthalenemethanamine
Additional Names: di(a-naphthylmethyl)amine; a-dinaphthomethylamine
Percent Composition: C 88.85%, H 6.44%, N 4.71%
Literature References: Prepd by catalytic hydrogenation of a-naphthonitrile: Rupe, Becherer, Helv. Chim. Acta 6, 880 (1923).

Chloroxine CAS Registry Number: 773-76-2 5,7-二氯-8-羟基喹啉

CAS Name: 5,7-Dichloro-8-quinolinol
Additional Names: 5,7-dichloro-8-hydroxyquinoline
Trademarks: Capitrol (Westwood)
Percent Composition: C 50.50%, H 2.35%, Cl 33.13%, N 6.54%, O 7.47%
Literature References: Prepd by chlorinating 8-quinolinol: Hebebrand, Ber. 21, 2977 (1888), F. J. Welcher, Organic Analytical Reagents vol. I (Van Nostrand, 1947) pp 328-329.

Dichlone CAS Registry Number: 117-80-6 2,3-二氯-1,4-萘醌

CAS Name: 2,3-Dichloro-1,4-naphthalenedione
Additional Names: 2,3-dichloro-1,4-naphthoquinoneTrademarks: Phygon; Phygon Paste; Phygon XL
Percent Composition: C 52.90%, H 1.78%, Cl 31.23%, O ...
Literature References: Prepd by chlorination of 1,4-naphthoquinone: Bertheim, Ber. 34, 1554 (1901); Brass, Köhler, Ber. 55, 2554 (1922); Sjöstrand, US 2975196 (1961 to Svenska Oljeslageri Aktiebolaget); by oxidation of 2,3-dichloro-5,8-dihydro-1,4-naphthohydroquinone: Gaertner, US 2750427 (1956 to Monsanto); by oxidation of 2,3-dichloro-p-benzoquinone: Grinev et al., Zh. Obshch. Khim. 29, 90 (1959). Toxicity data: G. W. Bailey, J. L. White, Residue Rev. 10, 97 (1965). Review: Ter Horst, Ind. Eng. Chem. 35, 1255 (1943).

Chlorquinaldol CAS Registry Number: 72-80-0 氯喹那多

CAS Name: 5,7-Dichloro-2-methyl-8-quinolinol
Additional Names: 5,7-dichloro-8-quinaldinol; 5,7-dichloro-8-hydroxyquinaldine; 5,7-dichloro-2-methyl-8-hydroxyquinoline; hydroxydichloroquinaldine;...
Literature References: Prepd by chlorination of 8-hydroxyquinaldine with or without formic acid as solvent: Senn, US 2411670 (1946 to Geigy).

Chlorocresol CAS Registry Number: 59-50-7 4-氯-3-甲基苯酚

CAS Name: 4-Chloro-3-methylphenol
Additional Names: 3-methyl-4-chlorophenol; 4-chloro-m-cresol; 6-chloro-m-cresol; 6-chloro-3-hydroxytoluene; 2-chloro-5-hydroxytoluene; parachlorometacresol
...
Literature References: Prepd by chlorination of m-cresol: DE 90847 (1897 to Kalle), Frdl. 4, 94; Laschinger, US 1847566 (1932), C.A. 26, 2471 (1932); Sah, Anderson, J. Am. Chem. Soc. 63, 3165 (1941). HPLC determn in pharmaceutical formulations: R. Gatti et al., J. Pharm. Biomed. Anal. 16, 405 (1997).

Hexobarbital CAS Registry Number: 56-29-1 环已巴比妥

CAS Name: 5-(1-Cyclohexen-1-yl)-1,5-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-(1-cyclohexen-1-yl)-1,5-dimethylbarbituric acid; 5-cyclohexenyl-3,5-dimethylbarbituric acid; me...
Literature References: Prepd by condensation of monomethylurea with methyl cyclohexenylmethylcyanoacetate in abs alcohol in the presence of sodium: US 1947944; cf. DE 595175; FR 753178. Comparative clinical trial in anesthesia: D. W. Barron et al., Br. J. Anaesth. 38, 802 (1966). GC determn in human plasma: D. D. Breimer, J. M. Van Rossum, J. Chromatogr. 88, 235 (1974). Pharmacokinetics: N. P. E. Vermeulen et al., Br. J. Clin. Pharmacol. 15, 459 (1983); M. Van der Graaff et al., Biopharm. Drug Dispos. 7, 265 (1986).

Phenoltetrachlorophthalein CAS Registry Number: 639-44-1 3,4,5,6-四氯酚酞

CAS Name: 4,5,6,7-Tetrachloro-3,3-bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone
Additional Names: 3,4,5,6-tetrachlorophenolphthalein
Percent Composition: C 52.67%, H 2.21%, Cl 31.09%, O 14.03%
Literature References: Prepd by condensation of phenol and tetrachlorophthalic acid or its anhydride: W. R. Orndorff, J. A. Black, Am. Chem. J. 41, 349 (1909); Zalkind, Belikova, Zh. Prikl. Khim. 8, 1210 (1935). Metabolism and hepatic chromosecretion of phthalein dyes: P. Hykes, J. Jirsa, Acta Univ. Carol. Med. 25, 135 (1979), C.A. 95, 111282z (1981).

p-tert-Pentylphenol CAS Registry Number: 80-46-6 对叔戊基苯酚

CAS Name: 4-(1,1-Dimethylpropyl)phenol
Additional Names: p-tert-amylphenol; 2-methyl-2-p-hydroxyphenylbutane
Trademarks: Pentaphen
Percent Composition: C 80.44%, H 9.82%, O 9.74%
Literature References: Prepd by condensation of tert-pentanol or 2-methyl-3-butanol with phenol in the presence of aluminum chloride: Huston, Hsieh, J. Am. Chem. Soc. 58, 439 (1936); Huston et al., ibid. 67, 899 (1945). Physical properties: Pardee, Weinrich, Ind. Eng. Chem. 36, 595 (1944). Toxicity study: H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 23, 95 (1962).

Clomethiazole CAS Registry Number: 533-45-9 氯美噻唑

CAS Name: 5-(2-Chloroethyl)-4-methylthiazole
Additional Names: 4-methyl-5-(b-chloroethyl)thiazole; chlorethiazol; chlormethiazole; S.C.T.Z.
Percent Composition: C 44.58%, H 4.99%, Cl 21.93%,...
Literature References: Prepd by condensation of thioformamide with chloroacetopropyl alcohol: Buchman, J. Am. Chem. Soc. 58, 1803 (1936); by chlorination of 4-methyl-5-(b-ethoxyethyl)thiazole: Clarke, Gurin, ibid. 57, 1876 (1935); by treating 5-(2-hydroxyethyl)-4-methylthiazole with thionyl chloride: Sawa, Ishida, J. Pharm. Soc. Jpn. 76, 337 (1956); by H2O2 oxidation of 2-mercapto-4-methyl-5-(b-chloroethyl)thiazole: CH 200248 (1938 to Hoffmann-La Roche). Prepn of methane and ethanedisulfonate: Charonnat et al., US 3031457 (1962).

Sulfamerazine CAS Registry Number: 127-79-7 磺胺甲基嘧啶

CAS Name: 4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide
Additional Names: N1-(4-methyl-2-pyrimidyl)sulfanilamide; N1-(4-methyl-2-pyrimidinyl)sulfanilamide; 2-sulfanilamido-4-methylpyrimi...
Literature References: Prepd by condensing 2-amino-4-methylpyrimidine with acetylsulfanilyl chloride followed by hydrolysis of the acetyl group: Roblin et al., J. Am. Chem. Soc. 62, 2002 (1940); Sprague et al., ibid. 63, 3028 (1941); Sprague, US 2407966 (1946 to Sharp Dohme). For prepn of 2-amino-4-methylpyrimidine see Benary, Ber. 63, 2601 (1930); Backer, Grevenstuk, Rec. Trav. Chim. 61, 291 (1942); cf. E. H. Northey, Sulfonamides (Reinhold, New York, 1948). Antimicrobial activity: Gill et al., Indian J. Vet. Sci. 32, 240 (1962); Vaichulis, Vedros, Chemotherapia 11, 315 (1966). Toxicity studies: Simunek et al., Vet. Med. (Prague) 13, 619 (1968). Kinetics of sulfamerazine decompn: Zajac, Diss. Pharm. Pharmacol. 22, 455 (1970). Comprehensive description: R. D. G. Woolfenden, Anal. Profiles Drug Subs. 6, 515-577 (1977).