其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Sulfaperine CAS Registry Number: 599-88-2 磺胺培林

CAS Name: 4-Amino-N-(5-methyl-2-pyrimidinyl)benzenesulfonamide
Additional Names: N1-(5-methyl-2-pyrimidinyl)sulfanilamide; 5-methyl-2-sulfanilamidopyrimidine; 2-sulfanilamido-5-methylpyrimidine...
Literature References: Prepd by condensing 2-amino-5-methylpyrimidine with acetylsulfanilyl chloride followed by hydrolysis of the acetyl group with NaOH: Sprague, US 2407966 (1946 to Sharp Dohme).

Sulfadiazine CAS Registry Number: 68-35-9 磺胺嘧啶

CAS Name: 4-Amino-N-2-pyrimidinylbenzenesulfonamide
Additional Names: 2-sulfanilamidopyrimidine; N1-2-pyrimidinylsulfanilamide; N1-2-pyrimidylsulfanilamide; 2-sulfanilylaminopyrimidine; sulfapy...
Literature References: Prepd by condensing 2-aminopyrimidine with acetylsulfanilyl chloride followed by hydrolysis of the acetyl group with NaOH: Roblin et al., J. Am. Chem. Soc. 62, 2002 (1940); Barber, GB 557055 (1943); Sprague, US 2407966 (1946 to Sharp Dohme); Winnek, Roblin, US 2410793 (1946 to Am. Cyanamid). Toxicological, chemotherapeutic and pharmacokinetic studies: Böhni et al., Chemotherapy 14, 195-226 (1969). In vitro activity of silver salt: Carr et al., Antimicrob. Agents Chemother. 4, 585 (1973). Use of silver salt in burns: C. L. Fox, Arch. Surg. 96, 184 (1968). Comprehensive description: H. Stober, W. DeWitte, Anal. Profiles Drug Subs. 11, 523-551 (1982).

Benzylideneacetone CAS Registry Number: 122-57-6 苄叉丙酮

CAS Name: 4-Phenyl-3-buten-2-one
Additional Names: benzalacetone; methyl styryl ketone; cinnamyl methyl ketone; acetocinnamone
Percent Composition: C 82.16%, H 6.89%, O 10.94%
Literature References: Prepd by condensing acetone and benzaldehyde by means of aq alkali: Drake, Allen, Org. Synth. 3, 17 (1923).

p-Bromomandelic Acid CAS Registry Number: 6940-50-7 对溴扁桃酸

CAS Name: 4-Bromo-a-hydroxybenzeneacetic acid
Additional Names: p-bromophenylglycolic acid
Percent Composition: C 41.59%, H 3.05%, Br 34.58%, O 20.77%
Literature References: Prepd by condensing bromobenzene with ethyl oxomalonate in presence of boron trifluoride: Riebsomer et al., J. Am. Chem. Soc. 60, 2974 (1938).

Chlorphenesin CAS Registry Number: 104-29-0 氯苯甘醚

CAS Name: 3-(4-Chlorophenoxy)-1,2-propanediol
Additional Names: p-chlorophenyl a-glyceryl ether
Trademarks: Adermykon; Mycil (BDH)
Percent Composition: C 53.35%, H 5.47%, Cl 17.50%, O 23....
Literature References: Prepd by condensing equimol amts of p-chlorophenol and glycidol in the presence of a tertiary amine or a quaternary ammonium salt as catalyst: Bradley, Forrest, GB 628497 (1949 to British Drug Houses).

Sulfonmethane CAS Registry Number: 115-24-2 乙丙二砜

CAS Name: 2,2-Bis(ethylsulfonyl)propane
Additional Names: diethylsulfondimethylmethane; propane-diethyl sulfone; sulfonal
Percent Composition: C 36.82%, H 7.06%, O 28.03%, S 28.09%
Literature References: Prepd by condensing ethyl mercaptan with acetone, then oxidizing with KMnO4: Fromm, Ann. 253, 140 (1889); cf. Baumann, Ber. 18, 883 (1885); Arch. Pharm. 226, 511 (1888); Bayer, Pharm. Z. 34, 98 (1889); DE 46333; Moragas, Uthoff, Chim. Ind. (Paris) 17, 284 (1927); Ramberg, Samén, C.A. 28, 6103 (1934); Suter, Organic Chemistry of Sulfur (New York, 1944) pp 735, 742. Soly data: Falck, J. Pharm. Chim. [7] 21, 279 (1920).

Sulfonethylmethane CAS Registry Number: 76-20-0 乙丁二砜

CAS Name: 2,2-Bis(ethylsulfonyl)butane
Additional Names: diethylsulfonmethylethylmethane; methylsulfonal
Trademarks: Trional
Percent Composition: C 39.65%, H 7.49%, O 26.41%, S 26.46%
Literature References: Prepd by condensing ethylmercaptan with methyl ethyl ketone and oxidizing the resulting mercaptol with KMnO4: Fromm, Ann. 253, 135 (1889); cf. Baumann, Ber. 18, 883 (1885); Arch. Pharm. 226, 511 (1888); Bayer, Pharm. Z. 34, 98 (1889); DE 46333; Moragas, Uthoff, Chim. Ind. (Paris) 17, 284 (1927); Ramberg, Samén, C.A. 28, 6103 (1934); Suter, Organic Chemistry of Sulfur (New York, 1944) pp 735, 742.

N,N ¢ -Diphenyl-p-phenylenediamine CAS Registry Number: 74-31-7 N,N'-二苯基对苯二胺

CAS Name: N,N-Diphenyl-1,4-benzenediamine
Additional Names: 1,4-dianilinobenzene; DPPD
Percent Composition: C 83.05%, H 6.19%, N 10.76%
Literature References: Prepd by condensing hydroquinone or p-aminophenol with aniline: Calm, Ber. 16, 2805 (1883); Clemens, Magoffin, US 2503712 (1950 to Kodak). Purification: Pecherer, US 2833824 (1958 to Hoffmann-La Roche).

Tannoform CAS Registry Number: 9010-29-1

CAS Name: Methyleneditannin
Additional Names: tannin-formaldehyde
Trademarks: Helgotan
Literature References: Prepd by condensing one mole formaldehyde with two moles tannin: Chemnitius, Pharm. Zentralhalle 68, 273 (1927); Schwyzer, Pharm. Ztg. 74, 1334 (1929).

Quinaldine Red CAS Registry Number: 117-92-0 喹哪啶红

CAS Name: 2-[2-[4-(Dimethylamino)phenyl]ethenyl]-1-ethylquinolinium iodide
Additional Names: 2-[p-(dimethylamino)styryl]-1-ethylquinolinium iodide; 2-(p-dimethylaminostyryl)quinoline ethiodide;...
Literature References: Prepd by condensing quinaldine ethyliodide and p-dimethylaminobenzaldehyde in alc in the presence of piperidine: König, J. Prakt. Chem. [2] 86, 172 (1912); DE 294744; Frdl. 14, 735.