其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Cyclopentobarbital CAS Registry Number: 76-68-6 环戊巴比妥

CAS Name: 5-(2-Cyclopenten-1-yl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-allyl-5-(2-cyclopenten-1-yl)barbituric acid
Trademarks: Cyclopal (Kytta-Siegfried)
Per...
Literature References: Prepd by condensing the ethyl ester of cyclopentenylmalonic acid with urea: Compagnie de Bethune: DE 589947 (1930), Frdl. 19, 1198; GB 349455; FR 38680.

Glyceryl p-Aminobenzoate CAS Registry Number: 136-44-7 利沙地酯

CAS Name: 1,2,3-Propanetriol 1-(4-aminobenzoate)
Additional Names: p-aminobenzoic acid monoglyceryl ester; monoglycerol p-aminobenzoate
Trademarks: Escalol 106 (Van Dyk)
Percent Compositi...
Literature References: Prepd by controlled esterification of p-aminobenzoic acid with glycerol.

Evan's Blue CAS Registry Number: 314-13-6 伊文思蓝

CAS Name: 6,6'-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid] tetrasodium salt
Additional Names: C.I. Direct Blue 53; 4,4'-bis[7-(1-amin...
Literature References: Prepd by coupling 1 mol of diazotized o-tolidine with 2 mols of Chicago acid (1-amino-8-naphthol-2,4-disulfonic acid): DE 35341; DE 38802 Frdl. 1, 469, 488 (1877-1887); DE 3949; DE 57327; DE 75469 Frdl. 3, 685, 687, 690 (1890-1894); Hartwell, Fieser, Org. Synth. coll. vol. II, 145 (1943). Diagnostic use: M. H. Nielsen, N. C. Nielsen, Scand. J. Clin. Lab. Invest. 14, 605 (1962); O. Linderkamp et al., Eur. J. Pediatr. 125, 135 (1977).

Trypan Red CAS Registry Number: 574-64-1 曲利本红

CAS Name: 4,4'-[(3-Sulfo[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-amino-2,7-naphthalenedisulfonic acid] pentasodium salt
Additional Names: 4,4'-[(3-sulfo-4,4'-biphenylene)bis(azo)]bis(3-amino-2,...
Literature References: Prepd by coupling diazotized 4,4¢-diaminobiphenyl-3-sulfonic acid with sodium 2-amino-3,6-naphthalenedisulfonate: Krauss, J. Am. Chem. Soc. 36, 961 (1914); Colour Index vol. 4 (3rd ed., 1971) p 4181.

Sebacoin CAS Registry Number: 96-00-4 2-羟基环癸酮

CAS Name: 2-Hydroxycyclodecanone
Additional Names: 1-cyclodecanol-2-one
Percent Composition: C 70.55%, H 10.66%, O 18.80%
Literature References: Prepd by cyclization of methyl or ethyl sebacate with sodium metal: Hansley, US 2228268 (1941 to du Pont); Prelog et al., Helv. Chim. Acta 35, 1598 (1952); Allinger, Org. Synth. coll. vol. IV, 840 (1963).

Octaverine CAS Registry Number: 549-68-8 奥他维林

CAS Name: 6,7-Dimethoxy-1-(3,4,5-triethoxyphenyl)isoquinoline
Additional Names: 1-(3,4,5-triethoxyphenyl)-6,7-dimethoxyisoquinoline; oktaverine
Percent Composition: C 69.50%, H 6.85%, N 3.52...
Literature References: Prepd by cyclodehydration and subsequent dehydrogenation of N-(3,4,5-triethoxybenzoyl)homoveratrylamine: FR 760825 (1934 to Asta Chemische Fabrik); cf. Goldberg, Shapero, J. Pharm. Pharmacol. 6, 171 (1954).

Tetracyanoethylene CAS Registry Number: 670-54-2 四氰基乙烯

CAS Name: Ethenetetracarbonitrile
Additional Names: 1,1,2,2-tetracyanoethene; D2,2'-bimalononitrile; TCNE
Percent Composition: C 56.26%, N 43.74%
Literature References: Prepd by debromination of dibromomalononitrile with copper powder in boiling benzene: Cairns et al., J. Am. Chem. Soc. 80, 2775 (1958).

Amylene CAS Registry Number: 513-35-9 2-甲基-2-丁烯

CAS Name: 2-Methyl-2-butene
Additional Names: b-isoamylene; trimethylethylene
Percent Composition: C 85.63%, H 14.37%
Literature References: Prepd by dehydration of tert-amyl alcohol in the presence of p-toluenesulfonic acid: Applequist, Babad, J. Org. Chem. 27, 288 (1962); by disproportionation of isobutene with propylene or 2-butene: Banks, Regier, Ind. Eng. Chem. Prod. Res. Dev. 10, 46 (1971).

Vital Red CAS Registry Number: 574-65-2

CAS Name: 3-Amino-4-[[4'-[(2-amino-6-sulfo-1-naphthalenyl)azo]-3,3'-dimethyl[1,1'-biphenyl]-4-yl]azo]-2,7-naphthalenedisulfonic acid trisodium salt
Additional Names: C.I. Direct Red 34; C.I. 23...
Literature References: Prepd by diazotization of o-tolidine and coupling the resulting tetrazotolidine first with 2-naphthylamine-3,6-disulfonic acid (amino R salt) and next with 2-naphthylamine-6-sulfonic acid (Brönner acid): Palkin, Evans, J. Am. Chem. Soc. 47, 429 (1925); DE 41095; Frdl. 1, 476; Colour Index vol. 4 (3rd ed., 1971) p 4191.

o-Iodobenzoic Acid CAS Registry Number: 88-67-5 邻碘苯甲酸

Percent Composition: C 33.90%, H 2.03%, I 51.17%, O 12.90%
Literature References: Prepd by diazotizing o-aminobenzoic acid and treating the resulting diazonium compound with aq KI.