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Sulfamerazine CAS Registry Number: 127-79-7 磺胺甲基嘧啶

CAS Name: 4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide
Additional Names: N1-(4-methyl-2-pyrimidyl)sulfanilamide; N1-(4-methyl-2-pyrimidinyl)sulfanilamide; 2-sulfanilamido-4-methylpyrimidine; sulfamethyldiazineTrademarks: Mesulfa (Triosol); Percoccide (A.C.F.)
Percent Composition: C 49.99%, H 4.58%, N 21.20%, O 12.11%, S 12.13%

📌 参考资料/链接：
Literature References: Prepd by condensing 2-amino-4-methylpyrimidine with acetylsulfanilyl chloride followed by hydrolysis of the acetyl group: Roblin et al., J. Am. Chem. Soc. 62, 2002 (1940); Sprague et al., ibid. 63, 3028 (1941); Sprague, US 2407966 (1946 to Sharp Dohme). For prepn of 2-amino-4-methylpyrimidine see Benary, Ber. 63, 2601 (1930); Backer, Grevenstuk, Rec. Trav. Chim. 61, 291 (1942); cf. E. H. Northey, Sulfonamides (Reinhold, New York, 1948). Antimicrobial activity: Gill et al., Indian J. Vet. Sci. 32, 240 (1962); Vaichulis, Vedros, Chemotherapia 11, 315 (1966). Toxicity studies: Simunek et al., Vet. Med. (Prague) 13, 619 (1968). Kinetics of sulfamerazine decompn: Zajac, Diss. Pharm. Pharmacol. 22, 455 (1970). Comprehensive description: R. D. G. Woolfenden, Anal. Profiles Drug Subs. 6, 515-577 (1977).

📄 详细内容

Properties: Crystals, mp 234-238°. uv max (water): 243, 257 nm (E1%1cm 875, 822); (0.1M HCl): 243, 307 nm (E1%1cm 625, 200); (ethanol): 271 nm (E1%1cm 835). Slowly darkens on exposure to light. Soly in water at 37°: 35 mg/100 ml at pH 5.5; 170 mg/100 ml at pH 7.5. Readily sol in dil mineral acids and in solns of potassium, ammonium and sodium hydroxides. Sparingly sol in acetone, slightly sol in alcohol, very slightly sol in ether, chloroform.
Melting point: mp 234-238°
Absorption maximum: uv max (water): 243, 257 nm (E1%1cm 875, 822); (0.1M HCl): 243, 307 nm (E1%1cm 625, 200); (ethanol): 271 nm (E1%1cm 835)
Derivative Type: Monosodium salt
CAS Registry Number: 127-58-2
Additional Names: Soluble sulfamerazine
Trademarks: Solumédine (Specia)
Percent Composition: C 46.15%, H 3.87%, N 19.57%, Na 8.03%, O 11.18%, S 11.20%
Properties: Crystals. Bitter, caustic taste. Hygroscopic. On prolonged exposure to humid air, it absorbs CO2 with the liberation of sulfamerazine and becomes incompletely sol in water. Its solns are alkaline to phenolphthalein (pH 10 or more). One gram dissolves in 3.6 ml water. Slightly sol in alc. Insol in ether, chloroform.
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides.
产品链接: 127-79-7››

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