CAS: 127-79-7; Sulfamerazine

该化合物是一种使用化学配方C11H12N4O2S的磺胺抗生素. 它通过竞争抑制细菌酶二氢乙酸合成酶,从而破坏叶酸合成,表现出细菌性活性.该化合物对抗药性和某些克型阴性细菌特别有效,有助于治疗尿道和呼吸道感染等传染病. 它在水中的中等溶液和在标准条件下的稳定性有助于配制成口服或注射剂量形式. 硫酰拉松由于具有广度的功效和成本效益,常常被用于兽医药物中. 临床使用时,建议认真考虑抗药性和潜在不利影响,如高度敏感反应.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号127-73-1 N-(4-(N-(4-甲基嘧啶... | CAS号108-52-1 2-氨基-4-甲基嘧啶 | CAS号121-60-8 对乙酰氨基苯磺酰氯 | CAS号19077-97-5 Acetamide,N-[4-... | CAS号7119-27-9 (E)-4-chlorobut... | CAS号57-67-0 磺胺脒 | CAS号5436-21-5 4,4-二甲氧基-2-丁酮 | CAS号13036-57-2 2-氯-4-甲基嘧啶 | CAS号14001-63-9 4-甲基-2-甲硫基嘧啶 | CAS号857410-69-6 2-[(N-acetyl-su... | CAS号127-73-1 N-(4-(N-(4-甲基嘧啶... | CAS号78373-14-5 Benzenesulfonam...

合成工艺路线路线简述

    2-氨基-4-甲基嘧啶置于吡啶,Sodium Hydroxide体系中,化学反应生成磺胺甲基嘧啶
    参考文献:N1-Sulfanilylamino-Alkyl-Pyrimidines
    标题:N1-Sulfanilylamino-Alkyl-Pyrimidines
    摘要:
    Doi:10.1021/ja01262A034

    专利信息


    专利号:US-10768157-B2
    优先权日:2015-10-20
    标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
    发明人:KABIR ABUZAR; FURTON KENNETH G
    权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
    摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

    专利号:US-9693999-B2
    优先权日:2011-01-26
    标题:Small molecule RNase inhibitors and methods of use
    发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
    权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
    摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

    专利号:US-9439423-B2
    优先权日:2007-10-29
    标 题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
    发明人:KAWANO FUMI; HIRAZAWA NORITAKA
    权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
    摘要:An antiparasitic agent for fish includes an inhibitor of folate synthesis and/or an inhibitor of folate activation as the active substance(s). A combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is disclosed. Sulfonamide is disclosed as suitable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist are disclosed as suitable inhibitors of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is effective against fish parasites belonging to the ciliate group.

    专利号:US-9265777-B2
    优先权日:2009-04-27
    标题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
    发明人:KAWANO FUMI; HIRAZAWA NORITAKA
    权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
    摘要:A method of controlling proliferation of fish parasites comprising the administration of 1 to 50 mg/kg fish body weight/day of an inhibitor of folate synthesis and/or an inhibitor of folate activation to fish continuously for 1 to 2 weeks. Using a combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is preferable, and a sulfonamide is preferable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist, etc., can be used as the inhibitor of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is particularly effective against parasites belonging to the ciliate group among fish parasites.

    专利号:WO-2009056955-A1
    优先权日:2007-10-30
    标题 :Amine-bearing phospholipids (abps), their synthesis and use
    发明人:ZUMBUEHL ANDREAS
    权利人:UNIV BASEL; ZUMBUEHL ANDREAS
    摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

    专利号:US-9868747-B2
    优先权日:2014-02-18
    标题:Marinopyrrole derivatives and methods of making and using same
    发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
    权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
    摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
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    主要参考文献


    1: Gniado K, Löbmann K, Rades T, Erxleben A. The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems. Int J Pharm. 2016 May 17;504(1-2):20-6. doi: 10.1016/j.ijpharm.2016.03.023. Epub 2016 Mar 16. doi: 10.1016/j.watres.2015.11.036. Epub 2015 Dec 2. doi: 10.1021/acs.molpharmaceut.5b00504. Epub 2015 Sep 8. doi: 10.1016/j.jpba.2014.07.008. Epub 2014 Jul 30. doi: 10.1002/jps.23978. Epub 2014 Apr 22. doi: 10.1016/j.saa.2014.01.057. Epub 2014 Jan 21. doi: 10.3109/10837450.2013.805777. Epub 2013 Jun 13. doi: 10.3109/03639045.2013.790408. Epub 2013 Apr 29. doi: 10.1002/jps.23042. Epub 2012 Jan 10. doi: 10.1002/jps.21837. Chinese. doi: 10.1016/j.jmgm.2008.05.007. Epub 2008 Jun 5. doi: 10.1007/s00216-008-2131-8. Epub 2008 May 22. doi: 10.1016/j.talanta.2007.11.030. Epub 2007 Nov 17.

    合成参考文献


    摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
    摘要:
    摘要:HANSCH,C ET AL. (1995)
    摘要:S74 | REFTPS | Transformation Products and Reactions from Literature | DOI:10.5281/zenodo.4318838
    摘要:A. V. Willi and W. Meier, Helv. Chim. Acta 39, 54 (1956).
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