其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Lead Selenite CAS Registry Number: 7488-51-9 亚硒酸铅(II)

Percent Composition: O 14.36%, Pb 62.01%, Se 23.63%
Literature References: Prepd by adding selenious acid or an alkali selenite to a soln of lead chloride or nitrate: Berzelius, cited in Mellor's vol. X, 833 (1930).

Dibenzyl Chlorophosphonate CAS Registry Number: 538-37-4 二苄基磷酰基氯

CAS Name: Phosphorochloridic acid bisphenylmethyl ester
Additional Names: benzyl phosphorochloridate; dibenzylchlorophosphate; DBPCl; dibenzylphosphoryl chloride
Percent Composition: C 56.68...
Literature References: Prepd by adding sulfuryl chloride to dibenzyl phosphite at 17-19° in CCl4 diluent: Atherton et al., J. Chem. Soc. 1948, 1106; by adding chlorine to dibenzyl phosphite in CCl4 at below 0°: Atherton et al., US 2490573 (1949 to Hoffmann-La Roche).

Cupric Ferrocyanide CAS Registry Number: 13601-13-3

CAS Name: Hexakis(cyano-C)ferrate(4-) copper(2+) (1:2)
Additional Names: hexacyanoferrate(4-) dicopper(2+); cupric hexacyanoferrate(II); Hatchett's brown; C.I. Pigment Brown 9
Percent Compos...
Literature References: Prepd by addition of K4Fe(CN)6 to an aqueous soln of a sol cupric salt: Weiser et al., J. Phys. Chem. 42, 945 (1938); 46, 99 (1942).

N,N-Diethylbenzhydrylamine CAS Registry Number: 519-72-2 N-(二苯基甲基)-N-乙基乙胺

CAS Name: N,N-Diethyl-a-phenylbenzenemethanamine
Additional Names: diethylaminodiphenylmethane
Percent Composition: C 85.30%, H 8.84%, N 5.85%
Literature References: Prepd by addn of an excess of phenylmagnesium bromide to N,N-diethylformamide and treating the reaction mixture with ammonium chloride: Maxim, Mavrodineanu, Bull. Soc. Chim. Fr. [5] 3, 1084 (1936). Proposed as an antihistaminic: Capraro, C.A. 41, 6989 (1947).

Ammonium Ferric Chromate CAS Registry Number: 7789-08-4

Additional Names: Ferric ammonium chromate
Percent Composition: Cr 34.00%, Fe 18.26%, H 1.32%, N 4.58%, O 41.85%
Literature References: Prepd by addn of NH3 to an aq soln of Fe(NO3)3.6H2O and CrO3: Weinland, Mergenthaler, Ber. 57B, 776 (1924).

Doisynolic Acid CAS Registry Number: 109784-48-7

CAS Name: 1-Ethyl-1,2,3,4,4a,9,10,10a-octahydro-7-hydroxy-2-methyl-2-phenanthrenecarboxylic acid
Additional Names: 3-hydroxy-16,17-secoestra-1,3,5(10)-trien-17-oic acid
Percent Composition: ...
Literature References: Prepd by alkali fusion of estrone: MacCorquodale et al., J. Biol. Chem. 99, 327 (1933); 101, 753 (1933); Heer, Miescher, Helv. Chim. Acta 28, 156 (1945). Sixteen isomers are possible. If the hydrogen atom at position 4a is a- and the hydrogen atom at position 10a is b-, the acid belongs to the A series. If the hydrogen at 4a is b- and the hydrogen at 10a is a-, the acid belongs to the B series. If both hydrogens are a-, the acid belongs to the C series. If both hydrogens are b-, the acid belongs to the D series: Miescher, Chem. Rev. 43, 367 (1948). If the hydrogen atom at position 1 and the methyl group at position 2 have either the a,a- or b,b-orientation, the acid is designated cis; if they are a,b- the acid is designated trans: L. F. Fieser, M. Fieser, Steroids (Reinhold, New York, 1959) pp 487-495. Synthesis of dl-cis and dl-trans of the A series and dl-cis of the B series: Anner, Miescher, Helv. Chim. Acta 29, 1889 (1946); 30, 1422 (1947). Synthesis of dl-cis of the C series: Jilck, Protiva, Collect. Czech. Chem. Commun. 23, 692 (1958). Stereochemistry of d-cis-form: Iriarte, Crabbe, Chem. Commun. 1972, 1110. Reviews: Shoppee, Annu. Rep. Prog. Chem. 44, 190 (1948); Miescher in Recent Progress in Hormone Research vol. 3, G. Pincus Ed. (Academic Press, New York, 1948) pp 47-69.

Hydracrylic Acid CAS Registry Number: 503-66-2 3-羟基丙酸

CAS Name: 3-Hydroxypropanoic acid
Additional Names: b-hydroxypropionic acid; ethylene lactic acid
Percent Composition: C 40.00%, H 6.71%, O 53.28%
Literature References: Prepd by alkaline hydrolysis of the nitrile: R. R. Read, Org. Synth. coll. vol. I, 321 (2nd ed., 1941).

Uramil CAS Registry Number: 118-78-5 乌拉米尔

CAS Name: 5-Amino-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-aminobarbituric acid; dialuramide; 5-amino-2,4,6-pyrimidinetriol
Percent Composition: C 33.57%, H 3.52%, N 29.36%, O 33...
Literature References: Prepd by boiling alloxantin with ammonium chloride: Wöhler, Liebig, Ann. 26, 241 (1838); by reduction of 5-nitrobarbituric acid with tin and HCl: Hartman, Sheppard, Org. Synth. coll. vol. II, 617 (1943); from barbituric acid, sodium nitrite and sodium hydrosulfite: Koppel, Robins, J. Am. Chem. Soc. 80, 2751 (1958).

Benzhydrylamine CAS Registry Number: 91-00-9 二苯甲胺

CAS Name: a-Phenylbenzenemethanamine
Additional Names: 1,1-diphenylmethylamine; a-aminodiphenylmethane
Percent Composition: C 85.21%, H 7.15%, N 7.64%
Literature References: Prepd by boiling benzophenone oxime with zinc dust and ammonia: Scholl, Ber. 60, 1247 (1927).

Cyacetacide CAS Registry Number: 140-87-4 氰乙酰肼

CAS Name: Cyanoacetic acid hydrazide
Additional Names: malononitrile hydrazide; cyanoacetohydrazide; cyanazide; cyanizide; cyanacethydrazine; cyanacethydrazide; cyanoethydrazide; cyanacetylhydr...
Literature References: Prepd by boiling ethyl or methyl cyanoacetate with hydrazine hydrate in alc: Rothenburg, Ber. 27, 687 (1894); Darapsky, Hillers, J. Prakt. Chem. 92[2], 313 (1915); Klosa, Arch. Pharm. 288, 453 (1955). Prepn of dosage forms: Muset, US 2849369 (1958 to Labs OM).