其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Octocrylene CAS Registry Number: 6197-30-4 奥克立林

CAS Name: 2-Cyano-3,3-diphenyl-2-propenoic acid 2-ethylhexyl ester
Additional Names: 2-ethylhexyl-2-cyano-3,3-diphenylacrylate
Trademarks: Eusolex OCR (Merck KGaA); Neo Heliopan 303 (Symrise...
Literature References: Photostable UV-B filter in sunscreens and cosmetics. Prepn: A. F. Strobel, S. C. Catino, BE 619809; eidem, US 3215724 (1962, 1965 both to General Aniline Film Corp.). Toxicity study: M. R. Odio et al., Fundam. Appl. Toxicol. 22, 355 (1994). HPTLC determn in sun protection lotions: J. Fisher, J. Sherma, J. Planar Chromatogr. Mod. TLC 13, 388 (2000).

Irgarol® (Ciba) CAS Registry Number: 28159-98-0 2-叔丁氨基-4-环丙氨基-6-甲硫基-s-三嗪

CAS Name: N-Cyclopropyl-N'-(1,1-dimethylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine
Additional Names: 2-(tert-butylamino)-4-(cyclopropylamino)-6-(methylthio)-s-triazine
Percent Composit...
Literature References: Photosystem-II (PSII) herbicide, inhibits photosynthetic electron transport in chloroplasts. Prepn: D. Berrer, C. Vogel, DE 1914014 (1969 to Agripat); eidem, US 3629256 (1971 to Geigy). Photodegradation and persistence in water: H. Okamura et al., J. Environ. Sci. Health B34, 225 (1999). Review of analytical methods: N. Voulvoulis et al., Chemosphere 38, 3503-3516 (1999). Ecological risk assessment: L. W. Hall, Jr. et al., Crit. Rev. Toxicol. 29, 367-437 (1999).

Ascorbic Acid CAS Registry Number: 50-81-7 抗坏血酸

CAS Name: L-Ascorbic acid
Additional Names: vitamin C; 3-oxo-L-gulofuranolactone; L-threo-hex-2-enonic acid g-lactone; L-3-keto-threo-hexuronic acid lactone; L-xylo-ascorbic acid; antiscorbutic...
Literature References: Physiological antioxidant. Coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Most primates (including humans), guinea pigs, and some birds and fish cannot synthesize ascorbic acid. Inadequate intake results in deficiency syndromes such as scurvy. Dietary sources include citrus fruits, potatoes, peppers, broccoli, cabbage, and rose hips. First isolated from the adrenal cortex of ox and later from lemons and paprika (originally called hexuronic acid): A. Szent-Györgyi, Biochem. J. 22, 1387 (1928); W. N. Haworth, A. Szent-Györgyi, Nature 131, 24 (1933). Structure studies: R. W. Herbert et al., J. Chem. Soc. 1933, 1270. Synthesis: R. G. Ault et al., ibid. 1419; T. Reichstein et al., Helv. Chim. Acta 16, 561, 1019 (1933); 17, 311, 510 (1934). Review of discovery, structure and synthesis: E. L. Hirst, Fortschr. Chem. Org. Naturst. 2, 132-159 (1939). Crystal structure: J. Hvoself, Acta Chem. Scand. 18, 841 (1964). Review of syntheses: T. C. Crawford, S. A. Crawford, Adv. Carbohydr. Chem. 37, 79-155 (1980). HPLC determn in plasma: J. Lykkesfeldt et al., Anal. Biochem. 229, 329 (1995). Discussion of use in the treatment of the common cold: L. Pauling, Proc. Natl. Acad. Sci. USA 68, 2678 (1971); H. Hemilä, Scand. J. Infect. Dis. 26, 1 (1994). Clinical applications in immunology, lipid metabolism and cancer: Int. J. Vitam. Nutr. Res. 1982, Suppl. 23, 294 pp. Comprehensive description: I. A. Al-Meshal, M. M. A. Hassan, Anal. Profiles Drug Subs. 11, 45-78 (1982). Reviews: G. M. Jaffe in Kirk-Othmer Encyclopedia of Chemical Technology vol. 24 (John Wiley Sons, New York, 3rd Ed., 1984) pp 8-40; "Vitamin C" in Vitamins, W. Friedrich, Ed. (Walter de Gruyter, Berlin, 1988) pp 929-1001. Review of pharmacology and clinical applications: M. Levine, N. Engl. J. Med. 314, 892-902 (1986); H. E. Sauberlich, Annu. Rev. Nutr. 14, 371-391 (1994).

Retinoic Acid CAS Registry Number: 302-79-4 维生素A酸; 视黄酸

Additional Names: (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; all-trans-retinoic acid; vitamin A acid; tretinoin
Trademarks: Aberel (Janssen-Cilag); ...
Literature References: Physiological metabolite of vitamin A, q.v. Effects gene expression via nuclear retinoic acid receptors (RAR); mediates cellular growth and differentiation. Prepn: D. A. van Dorp, J. R. Arens, Rec. Trav. Chim. 65, 338 (1946); C. D. Robeson et al., J. Am. Chem. Soc. 77, 4111 (1955). Single-step process: R. Marbet, DE 2061507; US 3746730 (1971, 1973 both to Hoffmann-La Roche). Crystal structure: C. H. Stam, C. H. MacGillavry, Acta Crystallogr. 16, 62 (1963). Toxicology: J. J. Kamm, J. Am. Acad. Dermatol. 6, 652 (1982). Clinical evaluation in treatment of photoaged skin: J. S. Weiss et al., J. Am. Med. Assoc. 259, 527 (1988); in promyelocytic leukemia: R. P. Warrell, Jr. et al., Leukemia 8, 929 (1994). Review of pharmacology and therapeutic potential: G. D. Goss et al., Crit. Rev. Clin. Lab. Sci. 29, 185-215 (1992). Book: The Retinoids, M. B. Sporn et al., Eds. (Raven Press, New York, 2nd ed., 1994) 679 pp.

Phenserine CAS Registry Number: 101246-66-6; 159652-53-6 (racemate) 苯丝氨酸

CAS Name: (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol phenylcarbamate (ester)
Additional Names: (-)-eseroline phenylcarbamate
Percent Composition: C 71.19%, H ...
Literature References: Physostigmine, q.v., analog; acetylcholinesterase inhibitor that reduces b-amyloid precursor protein (b-APP) formation. Prepn: M. Polonovski, Bull. Soc. Chim. Fr. 19, 46 (1916). See also: M. Pomponi et al., EP 154864; M. Brufani et al., US 5306825 (1985, 1994 both to Consig. Naz. Delle Ricerche). Anticholinesterase activity: M. Brzostowska et al., Med. Chem. Res. 2, 238 (1992). Pharmacology: S. Iijima et al., Psychopharmacology 112, 415 (1993). Pharmacokinetics: N. H. Greig et al., Acta Neurol. Scand. Suppl. 176, 74 (2000). Mode of action study for regulating b -APP expression: K. T. Y. Shaw et al., Proc. Natl. Acad. Sci. USA 98, 7605 (2001). Review of total synthesis and biological activity: N. H. Greig et al., Med. Res. Rev. 15, 3-31 (1995); A. Brossi et al., Aust. J. Chem. 49, 171-181 (1996). Review of development and therapeutic potential: U. Thatte, IDrugs 3,1222-1228 (2000).

Tectorigenin CAS Registry Number: 548-77-6 鸢尾黄素

CAS Name: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
Additional Names: 4',5,7-trihydroxy-6-methoxyisoflavone
Percent Composition: C 64.00%, H 4.03%, O 31.97%
Literature References: Phytoalexin aglycon isolated from rhizomes of Iris tectorum Maxim., Iridaceae, the extract of which is used as a traditional Chinese medicine. Isoln of the glycoside and aglycon: S. Shibata, J. Pharm. Soc. Jpn. 37, 380 (1927), C.A. 21, 30508 (1927); from Iris germanica Linnaeus: A. Kawase et al., Agric. Biol. Chem. 37, 145 (1973). Structure: Asahina et al., J. Pharm. Soc. Jpn. 48, 1087 (1928), C.A. 23, 27181 (1929); Shriner et al., J. Am. Chem. Soc. 61, 2322 (1939). Synthesis: Farkas, Várady, Ber. 93, 1269 (1960); W. Baker et al., J. Chem. Soc. C 1970, 1219. Inhibition of cyclooxygenase-2 induction: K. Ohuchi et al., Recent Adv. Nat. Prod. Res., Proc. 3rd Int. Symp. 1999, 12-24. Antioxidant effects: K.-T. Lee et al., Arch. Pharmacal Res. 23, 461 (2000).

Resveratrol CAS Registry Number: 501-36-0 白藜芦醇

CAS Name: 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol
Additional Names: trans-resveratrol; (E)-5-(p-hydroxystyryl)resorcinol; 3,4',5-stilbenetriol; 3,5,4'-trihydroxystilbene
Percent ...
Literature References: Phytoalexin found in a variety of plants; active ingredient of Asian folk medicine "Kojo-Kon" which is the powdered root of the Japanese knotweed. Isoln from white hellebore and structure: M. Takaoka, J. Fac. Sci., Hokkaido Imp. Univ. Ser. 3 3, 1 (1940); C.A. 34, 7887 (1940); from fescue grass: R. G. Powell et al., Phytochemistry 35, 335 (1994). Isoln of monomers, oligomers, isomers and glucosides from wine: F. Mattivi et al., J. Agric. Food Chem. 43, 1820 (1995). GC-MS determn: D. M. Goldberg et al., J. Am. Enol. Viticult. 46, 159 (1995). Produced as stress metabolite in response to fungal infection or injury: G. H. Dai et al., Physiol. Mol. Plant Pathol. 46, 177 (1995); P. Jeandet et al., J. Phytopathol. 143, 135 (1995). Antiplatelet aggregating activity: A. A. E. Bertelli et al., Int. J. Tissue React. 17, 1 (1995); and implications in coronary heart disease: C. R. Pace-Asciak et al., Clin. Chim. Acta 235, 207 (1995).

Genistein CAS Registry Number: 446-72-0 染料木素

CAS Name: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 4',5,7-trihydroxyisoflavone; prunetol; genisteol
Percent Composition: C 66.67%, H 3.73%, O 29.60%
Literature References: Phytoestrogen found in soy products; the aglucon of genistin and of sophoricoside. Specific protein kinase inhibitor. Prepn from the glucoside by hydrolysis with emulsin: Charaux, Rabaté, J. Pharm. Chim. [9] 1, 404 (1941); by hydrolysis with HCl in methanol: Walter, J. Am. Chem. Soc. 63, 3273 (1941). Isoln from prunus spp., Rosaceae: Hasegawa ibid. 79, 1738 (1957); from Podocarpus spicata R.Br., Podocarpaceae: Briggs, Cebalo, Tetrahedron 6, 145 (1959). Structure: Baker, Robinson, J. Chem. Soc. 1925, 1981; 1926, 2713; Walz, Ann. 489, 118 (1931). Synthesis: Baker, Robinson, J. Chem. Soc. 1928, 3115; Narasimhachari et al., J. Sci. Ind. Res. 12, 287 (1953); Yoder et al., Proc. Iowa Acad. Sci. 61, 271 (1954); Zemplén et al., Acta Chim. Acad. Sci. Hung. 19, 277 (1959). HPLC determn in biological fluids: J. G. Supko, L. R. Phillips, J. Chromatogr. B 666, 157 (1995); A. A. Franke et al, Proc. Soc. Exp. Biol. Med. 208, 18 (1995). Review of synthesis and isotopic labeling: K. Wähälä et al., ibid. 27-32. Series of articles on chemopreventive properties and mechanism of action: ibid. 103-115, 120-130; J. Nutr. 125, Suppl. 3, 777S-797S (1995).

Agrocybin CAS Registry Number: 544-44-5 8-羟基-2,4,6-辛三炔酰胺

CAS Name: 8-Hydroxy-2,4,6-octatriynamide
Percent Composition: C 65.31%, H 3.43%, N 9.52%, O 21.75%
Literature References: Phytotoxic acetylene responsible for killing of grass by fairy ring mushroom fungus. Isolation from basidiomycete Agrocybe dura: Kavanagh et al., Proc. Natl. Acad. Sci. USA 36, 102 (1950); from Marasmius oreades and activity: W. A. Ayer, P. A. Craw, Can. J. Chem. 67, 1371 (1989). Structure and synthesis: Bu'Lock et al., Chem. Ind. (London) 1954, 990; and spectrum: Ashworth et al., J. Chem. Soc. 1958, 950. Origin of the carbon skeleton: E. R. H. Jones et al., J. Chem. Res. Miniprint 1977, 744.

Pleconaril CAS Registry Number: 153168-05-9 普可那利

CAS Name: 3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
Additional Names: 5-[3-[2,6-dimethyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]pheno...
Literature References: Picornavirus replication inhibitor. Prepn: G. D. Diana, T. J. Nitz, EP 566199; eidem, US 5464848 (1993, 1995 both to Sterling Winthrop). Stability and HPLC determn of degradation products: A. B. C. Yu et al., Drug Dev. Ind. Pharm. 21, 1827 (1995). Activity spectrum vs enteroviruses: D. C. Pevear et al., Antimicrob. Agents Chemother. 43, 2109 (1999). Clinical pharmacokinetics in children: G. L. Kearns et al., ibid. 634; in adults: S. M. Abdel-Rahman, G. L. Kearns, J. Clin. Pharmacol. 39, 613 (1999). Clinical trial in induced respiratory infection: G. M. Schiff, J. R. Sherwood, J. Infect. Dis. 181, 20 (2000).