其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Pildralazine CAS Registry Number: 64000-73-3 3-肼基-6-((2-羟基丙基)甲基氨基)哒嗪二盐酸盐

CAS Name: 6-[(2-Hydroxypropyl)methylamino]-3(2H)-pyridazinone hydrazone
Additional Names: 3-hydrazino-6-[(2-hydroxypropyl)methylamino]pyridazine; (±)-1-[(6-hydrazino-3-pyridazinyl)methylam...
Literature References: Peripheral vasodilator with hypotensive activity; related to hydralazine, q.v. Prepn: G. Pifferi, DE 2154245; idem, US 3769278 (1972, 1973 both to I.S.F.); G. Pifferi et al., J. Med. Chem. 18, 741 (1975). Pharmacology in animals: L. Dorigotti et al., Pharmacol. Res. Commun. 8, 295 (1976); L. Dorigotti et al., Arzneim.-Forsch. 34, 876 (1984); in humans: L. Terzoli et al., Boll. Soc. Ital. Cardiol. 22, 1053 (1977). GLC determn in plasma: P. Ventura et al., J. Chromatogr. 161, 237 (1978). Clinical evaluation in essential hypertension: R. Pellegrini, G. Abbondati, Farmaco Ed. Prat. 32, 19 (1977). Pharmacokinetics and tissue binding: E. Noack et al., Arzneim.-Forsch. 37, 407 (1987).

Entacapone CAS Registry Number: 130929-57-6 恩他卡朋

CAS Name: (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Additional Names: (E)-a-cyano-N,N-diethyl-3,4-dihydroxy-5-nitrocinnamamide; (E)-2-cyano-N,N-diethyl-3-(3,4-dihyd...
Literature References: Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Prepn (stereochemistry unspecified): R. J. Bäckström et al., DE 3740383; eidem, US 5446194 (1988, 1995 both to Orion). Prepn of (E)-isomer: A. K. Pippuri et al., EP 426468; eidem, US 5135950 (1991, 1992 both to Orion). Pharmacology: E. Nissinen et al., Arch. Pharmacol. 346, 262 (1992). LC determn in plasma and urine: M. Karlsson, T. Wikberg, J. Pharm. Biomed. Anal. 10, 593 (1992). Identification of metabolites: T. Wikberg et al., Eur. J. Drug Metab. Pharmacokinet. 18, 359 (1993). Clinical pharmacokinetics: T. Keränen et al., Eur. J. Clin. Pharmacol. 46, 151 (1994). Clinical effect on levodopa bioavailability in Parkinson's disease: H. M. Routtinen, U. K. Rinne, J. Neurol. Neurosurg. Psychiatry 60, 36 (1996).

Muraglitazar CAS Registry Number: 331741-94-7 莫格列地

CAS Name: N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycineTrademarks: Pargluva (BMS)
Percent Composition: C 67.43%, H 5.46%, N 5.42%, O 21.68%
Literature References: Peroxisome proliferator-activated receptor (PPAR) a/g dual agonist. Prepn: P. T. Cheng, WO 0121602; eidem, US 6414002 (2001, 2002 both to Bristol-Myers Squibb); P. V. Devasthale et al., J. Med. Chem. 48, 2248 (2005). Review of development and therapeutic potential: D. Barlocco, Curr. Opin. Invest. Drugs 6, 427-434 (2005).

Cresol Purple CAS Registry Number: 2303-01-7 间甲酚紫

CAS Name: 4,4'-(1,1-Dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[3-methylphenol]
Additional Names: m-cresolsulfonphthalein
Percent Composition: C 65.95%, H 4.74%, O 20.92%, S 8.38%
Literature References: pH sensitive dye. Prepn: W. R. Orndorff, A. C. Purdy, J. Am. Chem. Soc. 48, 2212 (1926). Solvent effects: J. Barbosa et al., Mikrochim. Acta 106, 327 (1992). Ionization and spectral properties: R. Casula et al., Talanta 40, 1781 (1993); M. C. Aragoni et al., ibid. 42, 1157 (1995). Titrimetric determn: K. Vytras et al., Analyst 114, 479 (1989). Use as pH indicator for emission of NO2 in museum collections: J. Fenn, Polym. Prepr. 37, 170 (1996); in wine: E. N. Gaiao et al., Analyst 124, 1727 (1999); in buffered solns: S. Paula et al., Biochemistry 38, 3025 (1999).

Cetylpyridinium Chloride CAS Registry Number: 123-03-5 西吡氯铵

CAS Name: 1-Hexadecylpyridinium chloride
Trademarks: Ceepryn (J. B. Williams); Medilave (Farillon); Merocet (HMR); Pristacin; Pyrisept
Percent Composition: C 74.19%, H 11.27%, Cl 10.43%, N 4...
Literature References: Pharmacology and toxicology: J. Pharmacol. Exp. Ther. 74, 401 (1942). Review of early literature: C. L. Huyck, Am. J. Pharm. 116, 50 (1944). Toxicity data: J. W. Nelson, S. C. Lyster, J. Am. Pharm. Assoc. 35, 89 (1946).

Tylocrebrine CAS Registry Number: 6879-02-3 娃兒藤鹼

CAS Name: 9,11,12,13,13a,14-Hexahydro-2,3,5,6-tetramethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinoline
Additional Names: 2,3,5,6-tetramethoxyphenanthro[9,10:6',7']indolizidine
Percent Composition:...
Literature References: Phenanthroindolizidine alkaloid; isomeric with tylophorine, q.v. Isoln of l-isomer from Tylophora crebriflora S. T. Blake, Asclepiadaceae: E. Gellert et al., J. Chem. Soc. 1962, 1008; K. V. Rao et al., J. Pharm. Sci. 59, 1501 (1970). Antileukemic activity: E. Gellert, R. Rudzats, J. Med. Chem. 7, 361 (1964). d-Isomer isolated from Ficus septica, Moraceae. Synthesis of the dl-form and structure: E. Gellert et al., loc. cit.; B. Chauncy, E. Gellert, Aust. J. Chem. 23, 2503 (1970). Inhibits protein synthesis: G. R. Donaldson et al., Biochem. Biophys. Res. Commun. 31, 104 (1968); E. Battaner, D. Vasquez, Biochim. Biophys. Acta 254, 316 (1971). Mode of action studies: M. T. Huang, A. P. Grollman, Mol. Pharmacol. 8, 538 (1972). Review: R. S. Gupta, Antibiotics 6, 47 (1983).

Bucetin CAS Registry Number: 1083-57-4 羟丁酰胺苯醚

CAS Name: N-(4-Ethoxyphenyl)-3-hydroxybutanamide
Additional Names: 3-hydroxy-p-butyrophenetidide; b-hydroxybutyric acid p-phenetidide; p-ethoxy-N-(b-hydroxybutyryl)aniline
Trademarks: Betadi...
Literature References: Phenetidine derivative with analgesic and antipyretic activity. Prepn: G. Ehrhart et al., US 2830087 (1958 to Hoechst); and pharmacology: eidem, Arzneim.-Forsch. 15, 727 (1965). Toxicity data: H. Fujimura, Folia Pharmacol. Jpn. 62, 123 (1966). Metabolism in rabbits: J. Shibasaki et al., Chem. Pharm. Bull. 16, 1726, 2269 (1968). Synergistic effect with ethenzamide, q.v.: H. Kojima et al., Oyo Yakuri 16, 549 (1978), C.A. 90, 81035y (1979). TLC determn in saliva: P. Rohdewald, G. Drehsen, J. Chromatogr. 225, 427 (1981).

Enterolactone CAS Registry Number: 78473-71-9

CAS Name: (3R,4R)-rel-Dihydro-3,4-bis[(3-hydroxyphenyl)methyl]-2(3H)-furanone
Additional Names: trans-(±)-2,3-bis(3'-hydroxybenzyl)-g-butyrolactone; HPMF; HBBLPercent Composition: C 72.47%...
Literature References: Phenolic compound having 2,3-dibenzylbutane skeleton. First lignan, q.v., found in animal species. Determn in female urine from humans, vervet monkeys and characterization: S. R. Stitch et al., Nature 287, 738 (1980); K. D. R. Setchell et al., ibid. 740. Structure determn by GC-MS: eidem, Biochem. J. 197, 447 (1981); eidem, Biomed. Mass Spectrom. 10, 227 (1983). 1H-NMR, X-ray crystal structure: G. Cooley et al., J. Chem. Soc. Perkin Trans. 1 1984, 489. Synthesis: M. B. Groen, J. Leemhuis, Tetrahedron Lett. 21, 5043 (1980); G. Cooley et al., ibid. 22, 349 (1981); A. Pelter et al., ibid. 1549; P. A. Ganeshpure, R. Stevenson, Chem. Ind. (London) 1981, 778; A. Pelter et al., J. Chem. Soc. Perkin Trans. 1 1983, 643. Lignan excretion peaks during luteal phase of menstrual cycle: K. D. R. Setchell et al., J. Steroid Biochem. 12, 375 (1980). Excretion as glucuronide conjugate: M. Axelson, K. D. R. Setchell, FEBS Lett. 122, 49 (1980). Biosynthesis by intestinal bacteria: eidem, ibid. 123, 337 (1981). Effect of diet on lignan excretion: H. Aldercreutz et al., Med. Biol. 59, 337 (1981).

Netobimin CAS Registry Number: 88255-01-0 奈韦拉平

CAS Name: 2-[[[(Methoxycarbonyl)amino][[2-nitro-5-(propylthio)phenyl]amino]methylene]amino]ethanesulfonic acid
Additional Names: 2-[[[(methoxycarbonyl)amino][[2-nitro-5-(propylthio)phenyl]imino...
Literature References: Phenylguanidine anthelmintic. Prepn: M. M. Nafissi-Varchei, EP 50286; idem, US 4406893 (1982, 1983 both to Schering). Metabolism in animals: P. Delatour et al., J. Vet. Pharmacol. Ther. 9, 230 (1986). Anthelmintic efficacy in cattle: J. C. Williams et al., Am. J. Vet. Res. 46, 2188 (1985).

Struvite CAS Registry Number: 15490-91-2

Additional Names: Magnesium ammonium phosphate hexahydrate; guanite
Percent Composition: H 6.89%, Mg 9.23%, N 5.32%, O 66.81%, P 11.76%
Literature References: Phosphate mineral named in honor of H. C. G. von Sturve, a Russian naturalist, in 1845 by Ulex, a Swedish geologist. A component of urinary calculi and bat guano also found as a contaminant in canned foods, in waste management systems. Production by urease-splitting bacteria: H. Robinson, Proc. Cambridge Philos. Soc. 6, 360 (1889); J. Beavon, N. G. Heatley, J. Gen. Microbiol. 31, 167 (1962); M. T. Gonzalez-Munoz et al., Chemosphere 26, 1881 (1993). Identification in tinned seafood: M. T. Gilles, Seafood Processing in Food Processing Review 22, (Noyes Data Corp., Park Ridge, NJ, 1971) pp 31-58; in home-canned beef: J. G. Sebranek et al., J. Muscle Foods 4, 81 (1993). Precipitation in sludge digesters: C. Maqueda et al., Water Res. 28, 411 (1994). Crystal growth: R. J. C. McLean et al., Urol. Res. 18, 39 (1990). Thermodynamics of formation: J. R. Buchanan et al., Trans. ASAE 37, 617 (1994). Chemical control in waste systems: J. R. Buchanan et al., ibid. 1301. Review of struvite urolithiasis: formation, detection and dissolution: C.A. Osborne et al., Adv. Vet. Sci. Compar. Med. 29, 1-101 (1985). Review of struvite calculi: M. J. Gleeson, D. P. Griffith, Br. J. Urol. 71, 503-511 (1993).