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Ascorbic Acid CAS Registry Number: 50-81-7 抗坏血酸

CAS Name: L-Ascorbic acid
Additional Names: vitamin C; 3-oxo-L-gulofuranolactone; L-threo-hex-2-enonic acid g-lactone; L-3-keto-threo-hexuronic acid lactone; L-xylo-ascorbic acid; antiscorbutic vitamin; cevitamic acid
Trademarks: Ascorbicap (Valeant); Ascorbin (Montavit); Ascorvit (Jenapharm); Cantan (Aventis); Cebion (Merck KGaA); Cecon (Abbott); Celaskon (Leciva); Celin (GSK); Cetebe (GSK); Cevalin (Lilly); Ce-Vi-Sol (BMS); Cevitan (Aventis); Cewin (Sanofi-Synthelabo); C-Vimin (AstraZeneca); Hicee (Takeda); Hybrin (Pfizer); Laroscorbine (Roche); Redoxon (Roche); Ribena (GSK); Vitacimin (Takeda); Vitacin (Towa Yakuhin); Vitascorbol (Aventis)
Percent Composition: C 40.92%, H 4.58%, O 54.51%

📌 参考资料/链接：
Literature References: Physiological antioxidant. Coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Most primates (including humans), guinea pigs, and some birds and fish cannot synthesize ascorbic acid. Inadequate intake results in deficiency syndromes such as scurvy. Dietary sources include citrus fruits, potatoes, peppers, broccoli, cabbage, and rose hips. First isolated from the adrenal cortex of ox and later from lemons and paprika (originally called hexuronic acid): A. Szent-Györgyi, Biochem. J. 22, 1387 (1928); W. N. Haworth, A. Szent-Györgyi, Nature 131, 24 (1933). Structure studies: R. W. Herbert et al., J. Chem. Soc. 1933, 1270. Synthesis: R. G. Ault et al., ibid. 1419; T. Reichstein et al., Helv. Chim. Acta 16, 561, 1019 (1933); 17, 311, 510 (1934). Review of discovery, structure and synthesis: E. L. Hirst, Fortschr. Chem. Org. Naturst. 2, 132-159 (1939). Crystal structure: J. Hvoself, Acta Chem. Scand. 18, 841 (1964). Review of syntheses: T. C. Crawford, S. A. Crawford, Adv. Carbohydr. Chem. 37, 79-155 (1980). HPLC determn in plasma: J. Lykkesfeldt et al., Anal. Biochem. 229, 329 (1995). Discussion of use in the treatment of the common cold: L. Pauling, Proc. Natl. Acad. Sci. USA 68, 2678 (1971); H. Hemilä, Scand. J. Infect. Dis. 26, 1 (1994). Clinical applications in immunology, lipid metabolism and cancer: Int. J. Vitam. Nutr. Res. 1982, Suppl. 23, 294 pp. Comprehensive description: I. A. Al-Meshal, M. M. A. Hassan, Anal. Profiles Drug Subs. 11, 45-78 (1982). Reviews: G. M. Jaffe in Kirk-Othmer Encyclopedia of Chemical Technology vol. 24 (John Wiley Sons, New York, 3rd Ed., 1984) pp 8-40; "Vitamin C" in Vitamins, W. Friedrich, Ed. (Walter de Gruyter, Berlin, 1988) pp 929-1001. Review of pharmacology and clinical applications: M. Levine, N. Engl. J. Med. 314, 892-902 (1986); H. E. Sauberlich, Annu. Rev. Nutr. 14, 371-391 (1994).

📄 详细内容

Properties: Crystals (usually plates, sometimes needles, monoclinic system). Pleasant, sharp acidic taste. mp 190-192° (some dec). d 1.65. [a]D25 +20.5 to +21.5° (c = 1 in water); [a]D23 +48° (c = 1 in methanol). pH = 3 (5 mg/ml); pH = 2 (50 mg/ml); pK1 = 4.17; pK2 = 11.57. uv max at pH 2: 245 nm (E1%1cm 695); at pH 6.4: 265 nm (E1%1cm 940). Redox potential (first stage): E10 +0.166 V (pH 4). One gram dissolves in about 3 ml water, 30 ml alc, 50 ml abs alc, 100 ml glycerol, 20 ml propylene glycol. Soly in water: 80.0% at 100°; 40.0% at 45°. Insol in ether, chloroform, benzene, petr ether, oils, fats, fat solvents. Strong reducing agent. Stable to air when dry; aq solns are rapidly oxidized by air.
Melting point: mp 190-192° (some dec)
pKa: pK1 = 4.17; pK2 = 11.57
Optical Rotation: [a]D25 +20.5 to +21.5° (c = 1 in water); [a]D23 +48° (c = 1 in methanol)
Absorption maximum: uv max at pH 2: 245 nm (E1%1cm 695); at pH 6.4: 265 nm (E1%1cm 940)
Density: d 1.65
Derivative Type: Calcium hypophosphite
Additional Names: Asphocalcium
Trademarks: Calscorbat (Aerocid)
Percent Composition: C 25.72%, H 3.24%, Ca 14.30%, O 45.68%, P 11.05%
Derivative Type: Calcium salt
CAS Registry Number: 5743-27-1
Additional Names: Calcium ascorbate
Percent Composition: C 36.93%, H 3.62%, Ca 10.27%, O 49.19%
Literature References: Prepn: Ruskin, Merrill, Science
105, 504 (1947).
Properties: Dihydrate, triclinic crystals, [a]D20 +95.6° (c = 2.4). Freely sol in water. Practically insol in methanol, ethanol.
Optical Rotation: [a]D20 +95.6° (c = 2.4)
Derivative Type: Sodium salt
CAS Registry Number: 134-03-2
Additional Names: Sodium ascorbate
Trademarks: Cenolate (Abbott); Xitix (Woelm)
Percent Composition: C 36.38%, H 3.56%, Na 11.60%, O 48.46%
Literature References: Prepn: Holland,
US
2442005 (1948).
Properties: Minute crystals, dec 218°. [a]D20 +104.4°. Soly in water: 62 g/100 ml at 25°; 78 g/100 ml at 75°.
Optical Rotation: [a]D20 +104.4°
Use: As antimicrobial and antioxidant in foodstuffs.
Therap-Cat: Vitamin (antiscorbutic).
Therap-Cat-Vet: Vitamin (antiscorbutic).
Keywords: Vitamin/Vitamin Source; Vitamin C.
产品链接: 50-81-7››

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