其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Ruberythric Acid CAS Registry Number: 152-84-1

CAS Name: 1-Hydroxy-2-[(6-O-b-D-xylopyranosyl-b-D-glucopyranosyl)oxy]-9,10-anthracenedione
Additional Names: 1-hydroxy-2-anthraquinonyl 6-O-b-D-xylopyranosyl-b-D-glucopyranoside; b-2-alizarin p...
Literature References: Isoln from root of Rubia tinctorium L., Rubiaceae: Hill, Richter, Proc. R. Soc. London Ser. B 121, 547 (1937). Structure: Richter, J. Chem. Soc. 1936, 1701. Synthesis: Zemplén, Bognár, Ber. 72B, 913 (1939). Metabolism: Maehner, Dulce, Z. Klin. Chem. Klin. Biochem. 6, 99 (1968).

Sikkimotoxin CAS Registry Number: 18651-67-7 (3aR)-4c-羟基-6,7-二甲氧基-9c-(3,4,5-三甲氧基苯基)-(3ar,9at)-3a,4,9,9a-四氢-3H-萘[2,3-c]呋喃-1-酮

CAS Name: 3a,4,9,9a-Tetrahydro-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)naphtho[2,3-c]furan-1(3H)-one
Additional Names: 1-hydroxy-2-hydroxymethyl-6,7-dimethoxy-4-(3',4',5'-trimethoxyph...
Literature References: Isoln from roots and rhizomes of Podophyllum sikkimensis R. Chatterjee et Mukerjee, Berberidaceae: Chatterjee, Datta, Indian J. Physiol. Allied Sci. 4, 61 (1950). Structure: Chatterjee, Chakravarti, J. Am. Pharm. Assoc. Sci. Ed. 41, 415 (1952); Schreier, Helv. Chim. Acta 47, 1529 (1964).

Ascorbigen CAS Registry Number: 8075-98-7 (2X)-2-C-(1H-吲哚-3-基甲基)-alpha-L-苏-3-呋喃己糖酸gamma-内酯

CAS Name: 2-C-(1H-Indol-3-ylmethyl)-b-L-lyxo-3-hexulofuranosonic acid g-lactone mixt with 2-C-(1H-indol-3-ylmethyl)-b-L-xylo-3-hexulofuranosonic acid g-lactone
Percent Composition: C 59.01%, H ...
Literature References: Isoln from savoy cabbage juice: Procházka, Sanda, Collect. Czech. Chem. Commun. 25, 270 (1960). Prepn from L-ascorbic acid + glucobrassicin: Gmelin, Virtanan, Suom. Kemistil. 34B, 15 (1961), C.A. 55, 17774f (1961); from L-ascorbic acid + gramine methiodide: Procházka, Collect. Czech. Chem. Commun. 28, 544 (1963). Prepn from L-ascorbic acid + 3-hydroxymethylindole; forms two diastereoisomers: ascorbigen A as the main product and ascorbigen B as a minor product: Kiss, Neukom, Helv. Chim. Acta 49, 989 (1966); Kiss, Angew. Chem. 78, 1066 (1966).

Tanacetin CAS Registry Number: 1401-54-3 (3aS,5aS,6R,9aR,9bS)-6,9a-二羟基-5a-甲基-3,9-二亚甲基-4,5,6,7,8,9b-六氢-3aH-苯并[g]苯并呋喃-2-酮

CAS Name: [3aS-(3aa,5ab,6b,9aa,9bb)]-Decahydro-6,9a-dihydroxy-5a-methyl-3,9-bis(methylene)naphtho[1,2-b]furan-2(3H)-one
Additional Names: 1b,5a-dihydroxy-6b,7aH-selina-4(15),11(13)-dien-6,12-ol...
Literature References: Isoln from seed, herb, and flowers of Tanacetum vulgare L., Compositae: Homolle, J. Pharm. Chim. 7, 57 (1845); Jaretzky, Kühne, Arch. Pharm. 271, 353 (1933); Suchy, Collect. Czech. Chem. Commun. 27, 1058 (1962). Structure and absolute config: Samek et al., ibid. 38, 1971 (1973).

Visnadine CAS Registry Number: 477-32-7 维司那定

CAS Name: (2R)-2-Methylbutanoic acid (9R,10R)-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester
Additional Names: 2-methylbutyric acid 9-ester with 9,10...
Literature References: Isoln from seeds of Ammi visnaga L., Umbelliferae (Bishop's weed): Smith et al., Science 115, 520 (1952); eidem, J. Am. Chem. Soc. 79, 3534 (1957); Smith, Haber; Smith, Hosansky, US 2816118; US 2980699 (1957, 1961 both to Penick); Le Men, US 2995574 (1961 to Lab. Roger Bellon); Baddar et al., J. Chem. Soc. 1963, 4522. Synthesis of (±)-form: Shanbhag et al., Tetrahedron 21, 3591 (1965). Pharmacology and toxicology: Nkondi et al., Therapie 21, 1267 (1966); Erbring et al., Arzneim.-Forsch. 17, 283 (1967); Eyraud, Aurousseau, ibid. 23, 201 (1973).

Norhyoscyamine CAS Registry Number: 537-29-1 去甲莨菪碱

CAS Name: [3(S)-endo]-a-(Hydroxymethyl)benzeneacetic acid 8-azabicyclo[3.2.1]oct-3-yl ester
Additional Names: 1aH,5aH-nortropan-3a-ol (-)-tropate; 1-tropic acid 3a-nortropanyl ester; pseudohyos...
Literature References: Isoln from Solanaceae and structure: Carr, Reynolds, J. Chem. Soc. 101, 946 (1912). Synthesis: Fodor et al., Ber. 93, 2681 (1960). Identity with pseudohyoscyamine: Carr, Reynolds, loc. cit.; with solandrine: Petrie, C.A. 12, 23457 (1918).

Formononetin CAS Registry Number: 485-72-3 芒柄花黄素

CAS Name: 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 7-hydroxy-4'-methoxyisoflavone; biochanin B; formononetol; neochanin
Percent Composition: C 71.64%, H 4.51%, O...
Literature References: Isoln from soy-bean meal (Soja hispida): Walz, Ann. 489, 118 (1931); from clover species Trifolium subterraneum L. and T. pratense L., Leguminosae in which it is the major estrogenic factor: Bradbury, White, J. Chem. Soc. 1951, 3447; Bate-Smith, Swain, Chem. Ind. (London) 1953, 1127. Identity with biochanin B: Bose, J. Sci. Ind. Res. 15B, 325 (1956). Structure: Baker et al., J. Chem. Soc. 1933, 274. Synthesis: Wessely et al., Ber. 66, 685 (1933); Kagal et al., Tetrahedron Lett. 1962, 593. Biological half-life in Cicer arietinum L., Papilionatae: N. Amrhein, E. Diederich, Naturwissenschaften 67, 40 (1980). HPLC analysis: R. E. Carlson, J. Chromatogr. 198, 193 (1980). 13C-NMR study: H. C. Jha et al., Can. J. Chem. 58, 1211 (1980). Mutagenicity study: R. M. Bartholomew et al., Mutat. Res. 78, 317 (1980).

Primulaverin CAS Registry Number: 154-61-0 报春花根苷

Percent Composition: C 50.42%, H 5.92%, O 43.66%
Literature References: Isoln from species of Primulaceae: Thieme, Winkler, Pharmazie 26, 434 (1971). Synthesis: Chaudhury et al., J. Chem. Soc. 1948, 2220.

Streptozocin CAS Registry Number: 18883-66-4 链脲霉素

CAS Name: 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucopyranose
Additional Names: 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; streptozotocinTrademarks: Zanosar (Pharmacia U...
Literature References: Isoln from Streptomyces achromogenes fermentation broth: Herr et al., Antibiot. Annu. 1959-1960, 236; Bergy et al., FR 1434920 (1966 to Upjohn), C.A. 65, 17661h (1966). Structure and synthesis: Herr et al., J. Am. Chem. Soc. 89, 4808 (1967); Hardegger et al., Helv. Chim. Acta 52, 2555 (1969); Hessler, Jahnke, J. Org. Chem. 35, 245 (1970); P. F. Wiley et al., ibid. 44, 9 (1979). Diabetogenic effect: Rakieten et al., Cancer Chemother. Rep. 29, 91 (May 1963). Comparison of streptozotocin- and alloxan-induced diabetes: C. Rerup, F. Tarding, Eur. J. Clin. Pharmacol. 7, 89 (1969). Antileukemic activity: Bhuyan et al., Cancer Chemother. Rep. Part 1 56, 709 (1972). Biosynthetic study: S. Singaram et al., J. Antibiot. 32, 379 (1979). Review and evaluation of studies of carcinogenicity in laboratory animals: IARC Monographs 4, 221-227 (1974). Toxicity data: M. Iwasaki et al., J. Med. Chem. 19, 918 (1976). Review: B. Rudas, Arzneim.-Forsch. 22, 830-861 (1972); P. F. Wiley, Anticancer Agents Based on Natural Product Models, J. M. Cassidy, J. D. Douros, Eds. (Academic Press, New York, 1980) pp 167-200. Book: Streptozotocin: Fundamentals and Therapy, M. K. Agarwal, Ed. (Elsevier/North Holland Biomedical Press, New York, 1981) 309 pp.

Streptomycin B CAS Registry Number: 128-45-0 D-链吡他明,O-b-D-甘诺吡嗪-(1-4)-氧-脱氧-2-(甲基氨基)-a-L-葡萄吡吡烷基-(1-2)-O-5-脱氧-3-C-甲酰-a-L-lyxo呋喃osyl-(1-4)-N1,N3-双(氨基亚氨基甲基)-

Additional Names: Mannosidostreptomycin; mannosylstreptomycin
Percent Composition: C 43.60%, H 6.64%, N 13.18%, O 36.57%
Literature References: Isoln from streptomycin concentrates: Fried, Titus, J. Biol. Chem. 168, 391 (1947); 174, 57 (1948); Fried, Stavely, J. Am. Chem. Soc. 69, 1549 (1947); Fried, Titus, ibid. 70, 3615 (1948); O'Keeffe et al., ibid. 71, 2452 (1949); see also Langlykke, Perlman, US 2493489 (1950 to Squibb). Structure: Fried, Stavely, 113th Meeting Am. Chem. Soc., Chicago, Ill. (April 20, 1948) Abstracts of Papers p 25C; Peck et al., J. Am. Chem. Soc. 70, 3968 (1948); Stavely, Fried, ibid. 71, 135 (1949); 74, 5461 (1952).