其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Ergosine CAS Registry Number: 561-94-4 麦角生碱

CAS Name: 12'-Hydroxy-2'-methyl-5'a-(2-methylpropyl)ergotaman-3',6',18-trione
Percent Composition: C 65.79%, H 6.81%, N 12.79%, O 14.61%
Literature References: Isoln of ergosine and ergosinine from ergot: Smith, Timmis, J. Chem. Soc. 1937, 396. Structure: Stoll et al., Helv. Chim. Acta 34, 1544 (1951). Stereochemistry: Stoll et al., ibid. 37, 2039 (1954). Total synthesis of ergosine and ergosinine: Stadler et al., ibid. 47, 1911 (1964).

N-Methylephedrine CAS Registry Number: 552-79-4 甲基麻黄碱

CAS Name: a-[1-(Dimethylamino)ethyl]benzenemethanol
Additional Names: erythro-a-[1-(dimethylamino)ethyl]benzyl alcohol; 2-dimethylamino-1-phenylpropanol; N,N-dimethylnorephedrine
Percent Com...
Literature References: Isoln of l-form from Ephedra distachya L. (E. vulgaris Rich.), and allied Gnetaceae: Smith, J. Chem. Soc. 1927, 2056; Wolfes, Arch. Pharm. 268, 327 (1930). Prepn of l-form: Smith, loc. cit.; of d-, l-, and dl-forms, and resolution of racemic mixture: Nagai, Kanao, Ann. 470, 157 (1929); of dl-form: Pfanz, Müller, Arch. Pharm. 288, 11 (1955).

Thevetose CAS Registry Number: 5675-98-9 6-脱氧-3-O-甲基-α-L-葡萄糖拟糖

CAS Name: 6-Deoxy-3-O-methylglucose
Additional Names: 3-O-methylglucomethylose; quinovose 3-methyl ether
Percent Composition: C 47.19%, H 7.92%, O 44.90%
Literature References: Isoln of L-thevetose from Thevetia nereifolia Juss. and Tanghinia venenifera Poir., Apocynaceae: Frèrejacque, Compt. Rend. 221, 645 (1945); Frèrejacque, Hasenfratz, ibid. 222, 815 (1946); Sigg et al., Helv. Chim. Acta 38, 166 (1955); from thevetin: Helfenberger, Reichstein, ibid. 31, 1470 (1948); from Bowiea volubilis Harv., Liliaceae: Tschesche, Dölberg, Ber. 90, 2378 (1957). Synthesis: Blindenbacher, Reichstein, Helv. Chim. Acta 31, 1669 (1948). Isoln of D-thevetose from Adenium honghel D.C., Apocynaceae: Frèrejacque, Compt. Rend. 230, 127 (1950). Rare instance of two optical isomers of the same sugar being present in the vegetable kingdom.

ar-Turmerone CAS Registry Number: 532-65-0 芳姜黄酮

CAS Name: (6S)-2-Methyl-6-(4-methylphenyl)-2-hepten-4-one
Additional Names: 2-methyl-6-p-tolyl-2-hepten-4-one
Percent Composition: C 83.28%, H 9.32%, O 7.40%
Literature References: Isoln of naturally occurring (+)-form from Curcuma oil (Curcuma longa Linn., Zingiberaceae): H. Rupe et al., Helv. Chim. Acta 17, 372 (1934). Structure: H. Rupe, A. Gassmann, ibid. 19, 569 (1936). Abs config: V. K. Honwad, A. S. Rao, Tetrahedron 20, 2921 (1964). Total synthesis: A. I. Meyers, R. K. Smith, Tetrahedron Lett. 1979, 2749; T. Sato et al., ibid. 1980, 3377.

Vomitoxin CAS Registry Number: 51481-10-8 脱氧瓜萎镰菌醇

CAS Name: 12,13-Epoxy-3,7,15-trihydroxytrichothec-9-en-8-one
Additional Names: deoxynivalenol; dehydronivalenol
Percent Composition: C 60.80%, H 6.80%, O 32.40%
Literature References: Isoln of the trichothecene mycotoxin from Fusarium roseum and structure: N. Morooka et al., J. Food Hyg. Soc. Japan 13, 368 (1972); T. Yoshizawa, N. Morooka, Agric. Biol. Chem. 37, 2933 (1973). Isoln from F. graminearum: R. F. Vesonder et al., Appl. Microbiol. 26, 1008 (1973); eidem, Appl. Environ. Microbiol. 31, 280 (1976). Emetic and refusal activity in swine: D. M. Forsyth et al., ibid. 34, 547 (1977). HPLC analysis: G. A. Bennett et al., J. Am. Oil Chem. Soc. 58, 1002A (1981). Implicated as a chemical warfare agent with nivalenol, q.v. in Southeast Asia: N. Wade, Science 214, 34 (1981).

Lineatin CAS Registry Number: 65035-34-9 (+/-)-3,3,7-三甲基-2,9-二氧杂三环[3.3.1.04,7]壬烷

CAS Name: [1R-(1a,2b,5a,7b)]-3,3,7-Trimethyl-4,9-dioxatricyclo[3.3.1.02,7]nonane
Additional Names: 3,3,7-trimethyl-2,9-dioxatricyclo[3.3.1.04,7]nonane; 4,6,6-lineatin
Percent Composition: C ...
Literature References: Isoln of the unique tricyclic aggregation pheromone from ambrosia beetles, Trypodendron lineatum (Olivier): J. G. MacConnell et al., J. Chem. Ecol. 3, 549 (1977). Synthesis of (±)-form: K. Mori, M. Sasaki, Tetrahedron Lett. 1979, 1329; K. N. Slessor et al., J. Org. Chem. 45, 2290 (1980); K. Mori et al., Tetrahedron Lett. 23, 1921 (1982); L. Skattebol, Y. Stenstrom, ibid. 24, 3021 (1983); B. D. Johnston et al., J. Org. Chem. 50, 114 (1985). Synthesis of racemate and optical isomers: K. Mori, M. Sasaki, Tetrahedron 36, 2197 (1980). Short stereoselective synthesis: I. Aljancic-Solaja et al., Helv. Chim. Acta 70, 1302 (1987). Comparative activity of the isomers: J. H. Borden et al., Can. Entomol. 112, 107 (1980).

p-Coumaric Acid CAS Registry Number: 7400-08-0 对羟基肉桂酸

CAS Name: 3-(4-Hydroxyphenyl)-2-propenoic acid
Additional Names: p-hydroxycinnamic acid; b-[4-hydroxyphenyl]acrylic acid
Percent Composition: C 65.85%, H 4.91%, O 29.24%
Literature References: Isoln: Hlasiwetz, Ann. 136, 31 (1865); Bamberger, Monatsh. Chem. 12, 459 (1891). Prepn: Eigel, Ber. 20, 2528 (1887); Konek, Pacsu, Ber. 51, 856 (1918). uv data: Wheeler, Covarrubias, J. Org. Chem. 28, 2015 (1963).

Thiamine Disulfide CAS Registry Number: 67-16-3 二硫化硫胺水合物

CAS Name: N,N'-[Dithiobis[2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide]
Additional Names: aneurin disulfide; vitamin B1 disulfide
Trade...
Literature References: Isoln: Zima, Williams, Ber. 73, 941 (1940). Prepn: Warnat, US 2458453 (1949 to Hoffmann-La Roche); Matsukawa, Hirano, J. Pharm. Soc. Jpn. 73, 379 (1953); Hirano, Iwatsu, ibid. 73, 1115 (1953); Kawasaki, ibid. 76, 706 (1956). Bioavailability: N. Aoyagi et al., Chem. Pharm. Bull. 34, 281 (1986).

Valnoctamide CAS Registry Number: 4171-13-5 戊诺酰胺

CAS Name: 2-Ethyl-3-methylpentanamide
Additional Names: 2-ethyl-3-methylvaleramide; a-ethyl-b-methylvaleramide; valmethamideTrademarks: Axiquel (McNeil); Nirvanil (SKB)
Percent Composition: ...
Literature References: Isomer of valpromide, q.v. Prepn: Freifelder et al., J. Org. Chem. 26, 203 (1961). GLC determn in plasma: M. Bialer, B. Hoch, J. Chromatogr. 337, 408 (1985). Clinical pharmacokinetics: M. Bialer et al., Eur. J. Clin. Pharmacol. 38, 289 (1990).

Iodinated Glycerol CAS Registry Number: 5634-39-9 碘丙甘油

Additional Names: Iodopropylidene glycerol
Percent Composition: C 27.93%, H 4.30%, I 49.18%, O 18.60%
Literature References: Isomeric mixture of 67-75% of 2-(1-iodoethyl)-1,3-dioxolane-4-methanol or 2,3-(2-iodopropylidenedioxy)propanol and 33-25% of 2-(2-iodoethyl)-1,3-dioxolane-4-methanol or 2,3-(3-iodopropylidenedioxy)propanol. Prepn: Manchey et al., US 2872378 (1959 to The Denver Chem. Manuf.).