其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Uzarin CAS Registry Number: 20231-81-6 乌扎拉苷

CAS Name: (3b,5a)-3-[(2-O-b-D-Glucopyranosyl-b-D-glucopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
Percent Composition: C 60.16%, H 7.79%, O 32.05%
Literature References: Isoln from the dried root of a Gomphocarpus sp, Asclepiadaceae: Windaus, Haack, Ber. 63, 1377 (1930); Tschesche, Brathge, ibid. 85, 1042 (1952); Schmid et al., Helv. Chim. Acta 42, 72 (1959). Yields uzarigenin by enzymic cleavage. Structure: Tschesche, Bohle, Ber. 68, 2252 (1935). Structure of uzarigenin: Rangaswami, Reichstein, Helv. Chim. Acta 32, 939 (1949); Russel et al., ibid. 44, 1320 (1961). Unlike all other known cardiac glycosides, has the A/B-trans configuration: L. F. Fieser, M. Fieser, Steroids (Reinhold, New York, 1959) pp 762-763. Review: Heusser, Fortschr. Chem. Org. Naturst. 7, 101 (1950).

Nebularine CAS Registry Number: 550-33-4 9-(Β-D -呋喃核糖)嘌呤

CAS Name: 9-b-D-Ribofuranosyl-9H-purine
Percent Composition: C 47.62%, H 4.80%, N 22.21%, O 25.37%
Literature References: Isoln from the mushroom Clitocybe nebularis (Batsch.) Quel., Agaricaceae: Ehrenberg et al., Sven. Kem. Tidskr. 58, 269 (1946); Löfgren et al., Acta Chem. Scand. 8, 670 (1954); from a streptomycete: Isono, Suzuki, J. Antibiot. 13A, 270 (1960). In vitro toxicity towards sarcoma 180 cells, mouse embryonic fibroblasts and epithelial cells: J. J. Biescle et al., Cancer 8, 87 (1955). Synthesis: Brown, Weliky, J. Biol. Chem. 204, 1019 (1953); Fox et al., J. Am. Chem. Soc. 80, 1669 (1958); Hashizume, Iwamura, Tetrahedron Lett. 1966, 643; eidem, J. Org. Chem. 33, 1796 (1968). Crystal structure: T. Takeda, Acta Crystallogr. 30B, 825 (1974). Alternate syntheses: V. Nair, S. G. Richardson, Tetrahedron Lett. 1979, 1181; P. K. Gupta, D. S. Bhakuni, Indian J. Chem. 20B, 534 (1981). Toxicity studies: Truant, D'Amato, Fed. Proc. 14, 391 (1955).

Isoprene CAS Registry Number: 78-79-5 异戊二烯

CAS Name: 2-Methyl-1,3-butadiene
Percent Composition: C 88.16%, H 11.84%
Literature References: Isoln from the products of the pyrolysis of natural rubber: Williams, Trans. R. Soc. London 150, 241 (1860); Boonstra, van Amerongen, Ind. Eng. Chem. 41, 161 (1949). Structure: Euler, Ber. 30, 1989 (1897). Prepn from turpentine: Tilden, J. Chem. Soc. 45, 410 (1884); Bibb, US 2386537 (1945 to Newport Ind.); from terpenes: Davis et al., Ind. Eng. Chem. 38, 53 (1946); Bourbon, US 2547684 (1951 to Manufacture de Caoutchouc Michelin); by condensation of isobutylene and formaldehyde in acetic acid: Blomquist, Verdol, J. Am. Chem. Soc. 77, 78 (1955); Chaffe et al., FR 1294716 (1962 to Inst. Francais du Petrole); by dehydrogenation of isoamylenes from cracked gasolines: GB 875346 (Apr. 21, 1960 to Shell Int. Res. Maatschappij); Voge et al., US 3110746 (1963 to Shell); by dimerization of propylene followed by pyrolysis of the resulting 2-methyl-2-pentene: Gorin, Oblad, US 2404056 (1946 to Socony-Vacuum Oil); GB 913852 (1962 to Goodyear); by dehydrogenation of isopentane: Dempsey, US 2914588 (1959 to Sun Oil); Owen, US 2982795 (1961 to Phillips Petroleum); Stevenson, US 3088986 (1963 to Air Products Chem.); by reacting isoamylenes with methanol and pyrolizing and dehydrogenating the resulting tertiary ethers: Verdol, Walker, US 2972645 (1961 to Sinclair Refining). Toxicity: Gostinskii, C.A. 62, 15338a (1965). Reviews of isoprene and its polymers: Bean et al., "Isoprene Polymers" in Encyclopedia of Polymer Science and Technology vol. 7 (Interscience, New York, 1967) pp 782-855; Bailey, "Isoprene" in Vinyl and Diene Monomers (part 2), E. C. Leonard, Ed. (Wiley-Interscience, New York, 1971) pp 997-1148; W. M. Saltman in Kirk-Othmer Encyclopedia of Chemical Technology vol. 13 (Wiley-Interscience, New York, 3rd ed., 1981) pp 818-837; of carcinogenic risk: IARC Monographs 60, 215-232 (1994).

Desaspidin BB CAS Registry Number: 114-43-2 地沙匹定

CAS Name: 2-[[2,4-Dihydroxy-6-methoxy-3-(1-oxobutyl)phenyl]methyl]-3,5-dihydroxy-4,4-dimethyl-6-(1-oxobutyl)-2,5-cyclohexadien-1-one
Additional Names: 3'-[(5-butyryl-2,4-dihydroxy-3,3-dimethyl-...
Literature References: Isoln from the rhizome of Dryopteris austriaca (Jacq.) Wojnar, Polypodiaceae: Aebi et al., Helv. Chim. Acta 40, 266 (1957); from D. caucasica (A. Br.) Fraser-Jenkins et Corley: Widén et al., ibid. 56, 831 (1973). Structure: Aebi et al., ibid. 40, 572 (1957). Toxicity study: Airaksinan et al., Acta Pharmacol. Toxicol. 25, 33 (1967).

Rheadine CAS Registry Number: 2718-25-4 丽春花碱

CAS Name: (8b)-8-methoxy-16-methyl-2,3:10,11-bis[methylenebis(oxy)]rheadan
Additional Names: rhoeadine
Percent Composition: C 65.79%, H 5.52%, N 3.65%, O 25.04%
Literature References: Isoln from the seed capsules of corn poppy (Papaver rhoeas L., Papaveraceae): Hesse, Ann. 140, 145 (1866); Arch. Pharm. 228, 7 (1890); Awe, ibid. 274, 439 (1936); Awe, Winkler, ibid. 290, 367 (1957); Nemecková, Santavy, Collect. Czech. Chem. Commun. 27, 1210 (1962). Structure and stereochemistry: Santavy et al., ibid. 30, 3479 (1965); 32, 4452 (1967). Total synthesis: Klotzer et al., Helv. Chim. Acta 54, 2057 (1971); 55, 2228 (1972); Irie et al., J. Chem. Soc. Perkin Trans. 1 1972, 2986.

D -manno-Heptulose CAS Registry Number: 3615-44-9 甘露庚酮糖

Additional Names: D-manno-Ketoheptose
Percent Composition: C 40.00%, H 6.71%, O 53.29%
Literature References: Isoln from the wet pulp of the fruit of the avocado tree, Persea gratissima Gaertn. f. (P. americana Mill.), Lauraceae: LaForge, J. Biol. Chem. 28, 511 (1917); Montgomery, Hudson, J. Am. Chem. Soc. 61, 1654 (1939); Richtmyer in Methods in Carbohydrate Chemistry R. L. Whistler et al., Eds. vol. 1, 173 (1962).

Bufotenine CAS Registry Number: 487-93-4 蟾蜍色胺

CAS Name: 3-[2-(Dimethylamino)ethyl]-1H-indol-5-ol
Additional Names: 3-(2-dimethylaminoethyl)-5-indolol; 5-hydroxy-N,N-dimethyltryptamine; N,N-dimethylserotonin; 3-(b-dimethylaminoethyl)-5-hydr...
Literature References: Isoln from toads: Wieland et al., Ann. 513, 1 (1934); Wieland, Wieland, ibid. 528, 239 (1937); from toadstools: Wieland, Motzel, ibid. 581, 10 (1953). Isoln from Piptadenia peregrina Benth., Leguminosae: Stromberg, J. Am. Chem. Soc. 76, 1707 (1954). Synthesis: Hoshino, Shimodaira, Ann. 520, 19 (1935); Harley-Mason, Jackson, Chem. Ind. (London) 1952, 954; see also Serotonin; and Speetor, US 2708197 (1955 to Upjohn); Stoll et al., Helv. Chim. Acta 38, 1452 (1955). Activity: Bhattacharya, Sanyal, Indian J. Physiol. Pharmacol. 15, 133 (1971). Crystal and molecular structure: G. Falkenberg, Acta Crystallogr. 28B, 3219 (1972).

a -Farnesene CAS Registry Number: 502-61-4 金合欢烯,异构体混合物

CAS Name: 3,7,11-Trimethyl-1,3,6,10-dodecatetraene
Additional Names: 2,6,10-trimethyl-2,6,9,11-dodecatetraene; farnesene
Percent Composition: C 88.16%, H 11.84%
Literature References: Isoln of (E,E)-form from natural coating of apples: Huelin, Murray, Nature 210, 1260 (1966); Murray, Aust. J. Chem. 22, 197 (1969); from Dufour's gland in ants: Cavill et al., Tetrahedron Lett. 1967, 2201. Isoln of (Z,E)-form from oil of perilla: T. Sakai, Y. Hirose, Bull. Chem. Soc. Jpn. 42, 3615 (1969). Oxidation products of farnesene are believed to cause scald, a serious storage disorder of apples. Four possible geometric isomers. Synthetic studies: Ruzicka, Helv. Chim. Acta 6, 490, 501 (1923); Ruzicka, Capato, ibid. 8, 267 (1925). Configuration of (E,E)-form confirmed by synthesis from trans-b-farnesene: Brieger et al., J. Org. Chem. 34, 3789 (1969). Stereospecific synthesis of (E,Z)- and (Z,Z)-isomers: Anet, Aust. J. Chem. 23, 2101 (1970). Synthesis of (E,E)-form: Tanaka et al., J. Am. Chem. Soc. 97, 3252 (1975). (E,E)- and (Z,E)-forms are components of aphid alarm pheromones: J. A. Pickett, D. C. Griffiths, J. Chem. Ecol. 6, 349 (1980); of the trail pheromone of red imported fire ants: R. K. Vandermeer et al., Tetrahedron Lett. 22, 1651 (1981).

Fucosamine CAS Registry Number: 24724-90-1

CAS Name: 2-Amino-2,6-dideoxygalactose
Percent Composition: C 44.17%, H 8.03%, N 8.58%, O 39.22%
Literature References: Isoln of D-form from lipopolysaccharide of Chromobacterium violaceum: Crumpton, Davies, Biochem. J. 70, 729 (1958); from Bacillus licheniformis: Sharon et al., ibid. 93, 210 (1964). Isoln of L-form from type V Pneumococcus capsular polysaccharide: Barker et al., Nature 189, 303 (1961). Synthesis of L-form: Kuhn et al., Ann. 628, 186 (1959); J. Lehmann et al., Ber. 112, 1470 (1979); of D-form: Zehavi, Sharon, J. Org. Chem. 29, 3654 (1964).

b -Phellandrene CAS Registry Number: 555-10-2 β-水芹烯

CAS Name: 3-Methylene-6-(1-methylethyl)cyclohexene
Additional Names: p-mentha-1(7),2-diene; 3-isopropyl-6-methylene-1-cyclohexene; 4-isopropyl-1-methylene-2-cyclohexene
Percent Composition: ...
Literature References: Isoln of d-form from oil of water fennel (Phellandrium aquaticum L., Umbelliferae): Berry et al., J. Chem. Soc. 1937, 1448. Isoln of l-form from Canada balsam oil: Macbeth et al., ibid. 1938, 119. Structure: Wallach, Ann. 343, 28 (1905). Synthesis of dl-form: Deorha, Sareen, Rec. Trav. Chim. 82, 137 (1965); B. Singaram, J. Verghese, Indian J. Chem. 14B, 1003 (1976).