其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Raunescine CAS Registry Number: 117-73-7

CAS Name: (3b,16b,17a,18b,20a)-17-Hydroxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid methyl ester
Additional Names: 3,4,5-trimethoxybenzoyl methyl raunescate
Percent Compo...
Literature References: Isoln from Rauwolfia canescens L., R. tetraphylla and other Rauwolfia spp, Apocynaceae. Isoln and structure: Hosansky, Smith, J. Am. Pharm. Assoc. Sci. Ed. 44, 639 (1955); Huebner, Schlittler, J. Am. Chem. Soc. 79, 250 (1957); van Tamelen, Taylor, ibid. 79, 5256 (1957). Extraction: GB 833149 (1960 to Ciba).

Sarpagine CAS Registry Number: 482-68-8 萨杷晋碱

CAS Name: Sarpagan-10,17-diol
Additional Names: raupine
Percent Composition: C 73.52%, H 7.14%, N 9.03%, O 10.31%
Literature References: Isoln from Rauwolfia serpentina (L.) Benth., Apocynaceae: Stoll, Hofmann, Helv. Chim. Acta 36, 1143 (1953). Structure: Stauffacher et al., ibid. 40, 508 (1957); Poisson et al., Bull. Soc. Chim. Fr. 1957, 610; Biemann, J. Am. Chem. Soc. 83, 4801 (1961). Stereochemistry: Bartlett et al., ibid. 84, 622 (1962); Ohashi et al., Tetrahedron 19, 2241 (1963).

Reserpiline CAS Registry Number: 131-02-2 利舍匹林

CAS Name: (3b,19a,20a)-16,17-Didehydro-10,11-dimethoxy-19-methyloxayohimban-16-carboxylic acid methyl ester
Percent Composition: C 66.97%, H 6.84%, N 6.79%, O 19.39%
Literature References: Isoln from Rauwolfia serpentina Benth., Apocynaceae: Klohs et al., Chem. Ind. (London) 1954, 1264; from R. canescens L.: Stoll et al., Helv. Chim. Acta 38, 270 (1955). Stereochemistry: Shamma, Richey, J. Am. Chem. Soc. 85, 2507 (1963). Partial synthesis: S.-I. Sakai et al., Heterocycles 17, 99 (1982).

Pratensein CAS Registry Number: 2284-31-3 红车轴草素

CAS Name: 5,7-Dihydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 3',5,7-trihydroxy-4'-methoxyisoflavone
Percent Composition: C 64.00%, H 4.03%, O 31.97%
Literature References: Isoln from red clover (Trifolium pratense L., Leguminosae), structure and synthesis: E. Wong, J. Org. Chem. 28, 2336 (1963). Alternate syntheses: A. C. Jain, P. K. Bambab, Indian J. Chem. 26B, 488 (1987).

Rhodoquinone CAS Registry Number: 5591-74-2 2-氨基-5-(3,7,11,15,19,23,27,31,35,39-十甲基-2,6,10,14,18,22,26,30,34,38-四十碳十烯基)-3-甲氧基-6-甲基对苯醌

CAS Name: 2-Amino-5-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-3-methoxy-6-methyl-2,5-cyclohexadiene-1,4-dione
Additional Names: rhodoquinone-10
...
Literature References: Isoln from Rhodospirillum rubrum: Gloves, Threlfall, Biochem. J. 85, 14P (1962). Structure and synthesis: Moore, Folkers, J. Am. Chem. Soc. 87, 1409 (1965); 88, 567 (1966); Daves et al., ibid. 90, 5587 (1968).

z 2 -Tocopherol CAS Registry Number: 493-35-6 2H-1-苯并吡啶-6-醇,3,4-二氢-2,5,7-三甲基-2-(4,8,12-三甲基三乙烷)-

CAS Name: 3,4-Dihydro-2,5,7-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol
Additional Names: 2,5,7-trimethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol; 5,7-dimethyltocol
Percent ...
Literature References: Isoln from rice: Green, Marcinkiewicz, Nature 177, 86 (1956). Structure: Green et al., J. Chem. Soc. 1959, 3362. Synthesis: Karrer, Fritsche, Helv. Chim. Acta 21, 1234 (1938); Bergel et al., J. Chem. Soc. 1938, 1382; McHale et al., ibid. 1958, 1600.

Lysergamide CAS Registry Number: 478-94-4 麦角酰胺

CAS Name: 9,10-Didehydro-6-methylergoline-8b-carboxamide
Additional Names: lysergic acid amide; ergine
Percent Composition: C 71.89%, H 6.41%, N 15.72%, O 5.98%
Literature References: Isoln from Rivea corymbosa (L.) and from Ipomoea tricolor Cav., Convolvulaceae: Hofmann, Tscherter, Experientia 16, 414 (1964). Prepn from lysergic acid hydrazide: Ainsworth, US 2756235 (1956 to Lilly); from lysergic acid and phosgene-dimethylformamide complex: Patelli, Bernardi, US 3141887 (1964 to Farmitalia). Microbiological production: Rutschmann, Kobel, US 3219545 (1965 to Sandoz).

Piscidic Acid CAS Registry Number: 35388-57-9 (2R,3S)-2,3-二羟基-2-(4-羟基苄基)琥珀酸

CAS Name: 2,3-Dihydroxy-2-[(4-hydroxyphenyl)methyl]butanedioic acid
Additional Names: (p-hydroxybenzyl)tartaric acid
Percent Composition: C 51.57%, H 4.72%, O 43.71%
Literature References: Isoln from root bark of Piscidia piscipula (L.) Sarg. (P. erythrina L.), Leguminosae (Jamaica dogwood): Freer, Clover, Am. Chem. J. 25, 390 (1901); from Narcissus poeticus L., Amaryllidaceae: Smeby et al., J. Am. Chem. Soc. 76, 6127 (1954). Structure: Bridge et al., J. Chem. Soc. 1948, 257. Synthesis of p-O-methyl deriv: Buckle et al., ibid. 1954, 3981.

Centaurein CAS Registry Number: 35595-03-0 5-羟基-2-(3-羟基-4-甲氧基苯基)-3,6-二甲氧基-7-[(2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟基甲基)四氢吡喃-2-基]氧基苯并吡喃-4-酮

CAS Name: 7-(b-D-Glucopyranosyloxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one
Additional Names: 3',5,7-trihydroxy-3,4',6-trimethoxyflavone 7-b-D-glucoside
P...
Literature References: Isoln from root of Centaurea jacea L., Compositae: Bridel, Charaux, Compt. Rend. 175, 833, 1168 (1922). Structure: Farkas et al., Ber. 97, 1666 (1964).

Julocrotine CAS Registry Number: 492-87-5 N-[2,6-二氧代-1-(2-苯基乙基)-3-哌啶基]-2-甲基丁烷酰胺

CAS Name: N-[2,6-Dioxo-1-(2-phenylethyl)-3-piperidinyl]-2-methylbutanamide
Additional Names: yulocrotine; b-phenylethylimide of N-a-methylbutyrylglutamic acid
Percent Composition: C 68.33%, ...
Literature References: Isoln from root of Julocroton montevideensis Klotzsch, Euphorbiaceae: Anastasi, An. Asoc. Quim. Argent. 23, 348 (1925), C.A. 20, 2332 (1926). Structure: Nakano et al., J. Org. Chem. 26, 1184 (1961).