其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Fusarubin CAS Registry Number: 1702-77-8 1H-萘[2,3-c]吡喃-5,10-二酮,3,4-二氢-3,6,9-三羟基-7-甲氧基-3-甲基-

CAS Name: 3,4-Dihydro-3,6,9-trihydroxy-7-methoxy-3-methyl-1H-naphtho[2,3-c]pyran-5,10-dione
Additional Names: 5,8-dihydroxy-2-(hydroxymethyl)-6-methoxy-3-(2-oxopropyl)-1,4-naphthalenedione; 3-a...
Literature References: Isoln from Fusarium solani: Ruelius, Gauhe, Ann. 569, 38 (1950). Structure: Hardegger et al., Helv. Chim. Acta 47, 2027 (1964). Efficient total synthesis: Y. Tanoue et al., Bull. Chem. Soc. Jpn. 60, 2927 (1987).

Galangin CAS Registry Number: 548-83-4 高良姜素; 3,5,7-三羟基黄酮

CAS Name: 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Additional Names: 3,5,7-trihydroxyflavone; norizalpinin
Percent Composition: C 66.67%, H 3.73%, O 29.60%
Literature References: Isoln from galanga root, Alpininia officinarum, Hance and characterization: E. Jahns, Ber. 14, 2807 (1881). Prepn: T. Heap, R. Robinson, J. Chem. Soc. 129, 2336 (1926); J. J. Chavan, R. Robinson, ibid. 1933, 368. Mutagenicity studies: J. T. MacGregor, L. Jurd, Mutat. Res. 54, 297 (1978); J. P. Brown, P. S. Dietrich, ibid. 66, 223 (1979).

Tanghinigenin CAS Registry Number: 6875-16-7 7beta,8-环氧-3beta,14-二羟基-5beta-心甾-20(22)-烯内酯

CAS Name: (3b,5b,7b)-7,8-Epoxy-3,14-dihydroxycard-20(22)-enolide
Percent Composition: C 71.11%, H 8.30%, O 20.59%
Literature References: Isoln from glucosides: Sigg et al., Helv. Chim. Acta 38, 166 (1955). Structure: Flury, Reichstein, Ann. Chim. (Rome) 53, 23 (1963); Flury et al., Helv. Chim. Acta 48, 1113 (1965). Toxicity study: Chen, Henderson, J. Pharmacol. Exp. Ther. 111, 365 (1954).

Palustric Acid CAS Registry Number: 1945-53-5 长叶松酸

CAS Name: [1R-(1a,4ab,10aa)]-1,2,3,4,4a,5,6,9,10,10a-Decahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic acid
Additional Names: 13-isopropylpodocarpa-8,13-dien-15-oic acid
Per...
Literature References: Isoln from gum rosin: Loeblich et al., J. Am. Chem. Soc. 77, 2823 (1955); Joye et al., J. Org. Chem. 30, 654 (1965). Structure: Shuller et al., J. Am. Chem. Soc. 82, 1734 (1960). Prepn of the 4-epi-form: Tabacik, Poisson, Bull. Soc. Chim. Fr. 1969, 3264.

Halostachine CAS Registry Number: 495-42-1 盐穗草碱

CAS Name: (aR)-a-[(Methylamino)methyl]benzenemethanol
Additional Names: (-)-a-(methylaminomethyl)benzyl alcohol; 1-hydroxy-1-phenyl-2-methylaminoethane; (-)-phenyl(methylaminomethyl)carbinol; 2...
Literature References: Isoln from Halostachis caspica (Halostachis caspia): Menshikov, Rubinshtein, J. Gen. Chem. USSR 13, 801 (1943), C.A. 39, 1172 (1945). Synthesis: Menshikov, Borodina, J. Gen. Chem. USSR 17, 1569 (1947), C.A. 42, 2245 (1948). Configuration: Lukes et al., Collect. Czech. Chem. Commun. 26, 466 (1961). As a possible cause of ryegrass staggers: Aasen et al., Aust. J. Agric. Res. 20, 71 (1969). TLC determn in rye and fescue grasses: L. P. Bush, J. A. D. Jeffreys, J. Chromatogr. 111, 165 (1975). Vasoactive potential: C. B. Davis et al., Vet. Hum. Toxicol. 25, 6 (1983). One pot synthesis: P. Zandbergen et al., Tetrahedron 48, 3977 (1992).

Cytohemin CAS Registry Number: 19554-22-4

CAS Name: (SP-5-13)-Chloro[(4E,8E)-7-ethenyl-17-formyl-12-(1-hydroxy-5,9,13-trimethyl-4,8,12-tetradecatrienyl)-3,8,13-trimethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kN21,kN22,kN23,kN24]ferrate(2...
Literature References: Isoln from heart muscle: Warburg, Gewitz, Z. Physiol. Chem. 288, 1 (1951); Lemberg, Biochem. Z. 338, 97 (1963). Structure: M. Grassl et al., ibid. 337, 35 (1963); 338, 771 (1963). Side chain appears to be a mixture of saturated and unsaturated forms: R. Sayffert et al., 3rd Proc. Colloq. Hemes Hemoproteins, 1966, 45-59. Unsaturated form drawn.

a -Hederin CAS Registry Number: 27013-91-8 α-常春藤皂苷

Additional Names: Helixin (the saponin)
Percent Composition: C 65.57%, H 8.86%, O 25.57%
Literature References: Isoln from ivy leaves (Hedera helix L., Araliaceae): van der Haar, Arch. Pharm. 250, 424 (1912); 251, 632, 650; idem, Biochem. Z. 76, 335 (1916); idem, Ber. 54, 3142 (1921). Isoln and structure: Tschesche et al., Z. Naturforsch. 20b, 708 (1965).

Diginin CAS Registry Number: 467-53-8 毛地黄宁

CAS Name: (3b,12a,14b,17a,20S)-3-[(2,6-Dideoxy-3-O-methyl-D-lyxohexopyranosyl)oxy]-12,20-epoxypregn-5-ene-11,15-dione
Additional Names: 3b-(diginosyloxy)-12a,20a-epoxy-14b,17a-pregn-5-ene-11,15...
Literature References: Isoln from leaves of Digitalis purpurea L., Scrophulariaceae: Karrer in E. Barell Festschrift (1936) p 238; Chem. Zentralbl. 1936, II, 2727. Isoln: Shoppee, Reichstein, Helv. Chim. Acta 23, 975 (1940); Shoppee, ibid. 27, 426 (1944). Structure: Shoppee et al., J. Chem. Soc. 1962, 3610; Tschesche, Brügmann, Tetrahedron 20, 1469 (1964). Mild hydrolysis yields diginigenin and diginose. Attempted partial synthesis of diginigenin: Tschesche, Schwinum, Ber. 100, 464 (1967); Tschesche, Müller-Albrecht, Ber. 103, 350 (1970).

Leonurine CAS Registry Number: 24697-74-3 益母草碱

CAS Name: 4-Hydroxy-3,5-dimethoxybenzoic acid 4-[(aminoiminomethyl)amino]butyl ester
Additional Names: 4-hydroxy-3,5-dimethoxybenzoic acid d-guanidinobutyl ester; syringic acid d-guanidinobutyl...
Literature References: Isoln from leaves of Leonurus sibiricus L., Labiatae: Kubota, Nakajima, C.A. 25, 771 (1931). Structure: Goto et al., Tetrahedron Lett. 1962, 545. Revised structure: Kishi et al., ibid. 1968, 637. Structure and synthesis: Sugiura et al., Tetrahedron 25, 5155 (1969). Alternate synthesis: K. F. Cheng et al., Experientia 35, 571 (1979). Biological effect: H. W. Yeung et al., Planta Med. 31, 51 (1977).

Taxicatin CAS Registry Number: 90-71-1 (2R,3R,4S,5S,6R)-2-(3,5-二甲氧基苯氧基)-6-(羟基甲基)四氢吡喃-3,4,5-三醇

Additional Names: 3,5-Dimethoxyphenol glucoside
Percent Composition: C 53.16%, H 6.37%, O 40.47%
Literature References: Isoln from leaves of Taxus baccata L., Taxaceae: Lefebvre, Arch. Pharm. 245, 486 (1907); Merz, Preuss, ibid. 279, 134 (1941). Structure and synthesis from 3,5-dimethoxyphenol and a-acetobromoglucose: Merz, Preuss, loc. cit.