其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

b -Isosparteine CAS Registry Number: 24915-04-6 7,14-甲烷-2H,6H-di吡啶[1,2-a:1',2'-e][1,5]二氮杂辛,do十氢, (7S,7aS,14S,14aS)-

CAS Name: [7S-(7a,7ab,14a,14ab)]-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine
Additional Names: pusilline
Percent Composition: C 76.87%, H 11.18%, N 11.95%
Literature References: Isoln from Lupinus pusillus, Pursh., Leguminosae: Marion, Fenton, J. Org. Chem. 13, 780 (1948). Identity with pusilline: Greenhalgh, Marion, Can. J. Chem. 34, 456 (1956); identity of monohydrochloride with nonalupine and spathulatine: Marion, ibid. 29, 959 (1951). Synthesis: Bohlmann, Ber. 90, 653 (1957). Absolute configuration: Okuda, Tsuda, Chem. Ind. (London) 1961, 1115.

Lycodine CAS Registry Number: 20316-18-1 (4aR,12R)-2,3,4,4abeta,5,6-六氢-12-甲基-1H-5beta,10bbeta-丙桥-1,7-菲咯啉

Additional Names: [4aR-(4aa,5a,10ba,12R*)]-2,3,4,4a,5,6-Hexahydro-12-methyl-1H-5,10b-propano-1,7-phenanthroline
Percent Composition: C 79.29%, H 9.15%, N 11.56%
Literature References: Isoln from Lycopodium annotinum L., Lycopodiaceae: F. A. L. Anet, C. R. Eves, Can. J. Chem. 36, 902 (1958). Structure: W. A. Ayer, G. G. Iverach, ibid. 38, 1823 (1960); F. A. L. Anet, M. V. Rao, Tetrahedron Lett. 1960, 9. Synthesis of (±)-form: E. Kleinman, C. H. Heathcock, ibid. 1979, 4125; C. H. Heathcock et al., J. Am. Chem. Soc. 104, 1054 (1982).

Annotinine CAS Registry Number: 559-49-9 蔓杉石松宁

Percent Composition: C 69.79%, H 7.69%, N 5.09%, O 17.43%
Literature References: Isoln from Lycopodium annotinum L., Lycopodiaceae: Manske, Marion, Can. J. Res. 21B, 92 (1943). Structure: Przybylska, Marion, Can. J. Chem. 35, 1075 (1957); Wiesner et al., Tetrahedron 4, 87 (1958); Przybylska, Ahmed, Acta Crystallogr. 11, 718 (1958). Stereochemistry: Wiesner et al., Tetrahedron Lett. 1961, 187; Ho, ibid. 1969, 1307. Synthesis: Wiesner et al., Can. J. Chem. 47, 433 (1969). Biogenesis: Leete, Tetrahedron 3, 313 (1958).

Armepavine CAS Registry Number: 524-20-9 杏黄罂粟碱

CAS Name: 4-[[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenol
Additional Names: (-)-6,7-dimethoxy-1-p-hydroxybenzyl-2-methyl-1,2,3,4-tetrahydroisoquinoline
Perce...
Literature References: Isoln from Papaver armeniacum (L.) DC., Papaveraceae: Konowalowa et al., Ber. 68, 2161 (1935); from Euonymus europaea L., Celastraceae: Bishay et al., J. Pharm. Pharmacol. 23 (Suppl), 233S (1971); from Rhamnus frangula L., Rhamnaceae: Pailer, Haslinger, Monatsh. Chem. 103, 1399 (1972). Structure: eidem, J. Gen. Chem. USSR 10, 641 (1940). Synthesis: Marion et al., J. Org. Chem. 15, 216 (1950); Gibson et al., J. Heterocycl. Chem. 3, 99 (1966). Resolution: Knabe, Horn, Arch. Pharm. 300, 547 (1967); Farber, Giacomazi, Chem. Ind. (London) 1968 (2), 57.

Petroselinic Acid CAS Registry Number: 593-39-5 顺-6-十八碳烯酸

CAS Name: cis-6-Octadecenoic acid
Additional Names: petroselic acid; 5-heptadecylene-1-carboxylic acid; D5-octadecylenic acid
Percent Composition: C 76.54%, H 12.13%, O 11.33%
Literature References: Isoln from parsley seed oil, the oil extracted from dried ripe seed of Petroselinum hortense Hoffm., Umbelliferae: Fore et al., J. Am. Oil Chem. Soc. 37, 490 (1960).

Periplocin CAS Registry Number: 13137-64-9 杠柳毒苷

CAS Name: 3b-[(2,6-Dideoxy-4-O-b-D-glucopyranosyl-b-D-ribo-hexopyranosyl)oxy]-5b,14-dihydroxycard-20(22)-enolide
Additional Names: glucoperiplocymarin; periplocoside
Percent Composition: C 6...
Literature References: Isoln from Periploca graeca L., Asclepiadaceae: Lehmann, Arch. Pharm. 235, 157 (1897); W. A. Jacobs, A. Hoffmann, J. Biol. Chem. 79, 519 (1928); from Strophanthus preussii Engl. and Pax., Apocynaceae: Ruppol, Trukovic, J. Pharm. Belg. 10, 221 (1955), C.A. 50, 12089d (1956). Structure: Stoll, Renz, Helv. Chim. Acta 22, 1193 (1939). Pharmacology and toxicity: M. H. MacKeith, J. Pharmacol. Exp. Ther. 27, 449 (1926).

Congressane CAS Registry Number: 2292-79-7 双金刚烷

CAS Name: Decahydro-3,5,1,7-[1,2,3,4]butanetetraylnaphthalene
Additional Names: pentacyclo[7.3.1.14,12.02,7.06,11]tetradecane; diamantane
Percent Composition: C 89.29%, H 10.71%
Literature References: Isoln from petroleum: Hala et al., Angew. Chem. Int. Ed. 5, 1045 (1966). Synthesis: Cupas et al., J. Am. Chem. Soc. 87, 917 (1965); Gund et al., J. Org. Chem. 39, 2979 (1974). Structure: Karle, Karle, J. Am. Chem. Soc. 87, 918 (1965).

Hyodeoxycholic Acid CAS Registry Number: 83-49-8 猪去氧胆酸

CAS Name: (3a,5b,6a)-3,6-Dihydroxycholan-24-oic acid
Additional Names: 3a,6a-dihydroxy-5b-cholanic acid; a-hyodeoxycholic acid; hyodesoxycholic acid
Percent Composition: C 73.43%, H 10.27%, ...
Literature References: Isoln from pig bile: Wieland, Gumlich, Z. Physiol. Chem. 215, 18 (1933); Trickey, US 2547726 (1951 to U.S. Rubber); Fogle, US 2745849 (1956 to Armour); Buckley, Ziegler, US 2758120 (1956 to Canada Packers); Liebig, US 3006927 (1961 to Riedel-de Haen). Configuration: Moffett, Hoehn, J. Am. Chem. Soc. 69, 1995 (1947).

Acacic Acid CAS Registry Number: 1962-14-7 3beta,16alpha,21beta-三羟基齐墩果-12-烯-28-酸

CAS Name: (3b,16a,21b)-Trihydroxyolean-12-en-28-oic acid
Percent Composition: C 73.73%, H 9.90%, O 16.37%
Literature References: Isoln from pods of Acacia concinna D.C., Leguminosae: Varshney, Shamsuddin, Tetrahedron Lett. 1964, 2055; from bark of A. concinna D.C.: R. Banerji, S. K. Nigam, J. Indian Chem. Soc. 57, 1043 (1980). Structure and stereochemistry: Varshney et al., ibid. 1965, 1187. Revised structure: A. K. Barua et al., Trans. Bose Res. Inst. (Calcutta) 39, 61 (1976), C.A. 87, 53460c (1977).

Wildfire Toxin CAS Registry Number: 32190-57-1 L-苏氨酸,N-[2-氨基-4-(3-羟基-2-氧基-3-扑采替二尼)-1-氧丁基]-

CAS Name: N-[2-Amino-4-(3-hydroxy-2-oxo-3-azetidinyl)-1-oxobutyl]-L-threonine
Percent Composition: C 45.67%, H 6.62%, N 14.53%, O 33.18%
Literature References: Isoln from Pseudomonas tabaci, the bacterium responsible for wildfire disease of tobacco: Woolley et al., J. Biol. Chem. 197, 409 (1952). Highly toxic to a variety of organisms including bacteria, algae, higher plants and animals: Sinden et al., Toxicol. Appl. Pharmacol. 14, 82 (1969). Mode of action: Lovrekovich et al., Nature 197, 917; 198, 710 (1963). Structural studies: Woolley et al., J. Biol. Chem. 215, 485 (1955); Stewart, J. Am. Chem. Soc. 83, 435 (1961). Revised structure: idem, Nature 229, 174 (1971).