Properties: Amorphous yellowish powder. Readily sol in water. Acid hydrolysis yields periplogenin, q.v., and periplobiose (cymarose + glucose, C13H24O9, [a]D20 +32°). Enzymatic hydrolysis with strophanthobiase splits off glucose, yielding periplocymarin. The biose is attached to the hydroxyl group at C-3 of the aglycon. LD in rabbits, rats (mg/kg): 10, 480 s.c. (MacKeith).
Optical Rotation: [a]D20 +32°
Toxicity data: LD in rabbits, rats (mg/kg): 10, 480 s.c. (MacKeith)
Derivative Type: Dihydrate
Properties: Fine needles from water. Becomes anhydr after drying for one hour in high vacuum at 105°. mp 224° when bath is preheated to 200°. [a]D20 +23° (c = 0.7 in alcohol). One gram dissolves in ~20 ml boiling water, at 25° the soly is ~1:2500. Freely sol in alcohol. Almost insol in ether, chloroform.
Melting point: mp 224° when bath is preheated to 200°
Optical Rotation: [a]D20 +23° (c = 0.7 in alcohol)
Derivative Type: Tetraacetylperiplocin
Percent Composition: C 61.10%, H 7.46%, O 31.44%
Properties: Six-sided prisms from alcohol, mp 195°. [a]D20 +20° (c = 0.5 in alcohol). Sol in alcohol, chloroform; very slightly sol in water.
Melting point: mp 195°
Optical Rotation: [a]D20 +20° (c = 0.5 in alcohol)
产品链接: 13137-64-9››