其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Surinamine CAS Registry Number: 537-49-5 N-甲基-L-酪氨酸

CAS Name: N-Methyl-L-tyrosine
Additional Names: andirine; angeline; geoffroyine; ratanhine
Percent Composition: C 61.52%, H 6.71%, N 7.17%, O 24.59%
Literature References: Isoln from bark of Andira retusa Kunth. (Geoffroya retusa Lam.), Leguminosae: Hiller-Bombein, Arch. Pharm. 230, 513 (1892). Prepn of inactive compd: Kanevskaya, J. Prakt. Chem. 124, 48 (1929). Prepn of L-form: Kanao, J. Pharm. Soc. Jpn. 66, 4 (1946); Huguenin, Boissonnas, Helv. Chim. Acta 44, 213 (1961). Prepn of D-form: Izumiya, Nagamatsu, Bull. Chem. Soc. Jpn. 25, 265 (1952).

Hordenine CAS Registry Number: 539-15-1 大麦芽碱

CAS Name: 4-[2-(Dimethylamino)ethyl]phenol
Additional Names: N,N-dimethyltyramine; p-hydroxy-N,N-dimethylphenethylamine; anhaline; eremursine; peyocactine
Percent Composition: C 72.69%, H 9....
Literature References: Isoln from barley germs: Leger, Compt. Rend. 142, 108 (1906); 143, 234, 916 (1906); 144, 488 (1907); Erspamer, Falconieri, Naturwissenschaften 39, 431 (1952). Structure: Leger, Bull. Soc. Chim. Fr. [3] 35, 868 (1906); [4] 1, 148 (1907); Gaebel, Arch. Pharm. 244, 441 (1906). Synthesis from phenethyl alcohol: Barger, J. Chem. Soc. 95, 2193 (1909); from tyrosine: Raoul, Compt. Rend. 204, 74 (1937); from p-(b-hydroxyethyl)anisole: Cheng et al., J. Am. Chem. Soc. 73, 4081 (1951).

Allotetrahydrocortisone CAS Registry Number: 547-77-3 5-Alpha-孕烷-3-beta, 17,21-三醇-11,20-二酮

CAS Name: (3a,5a)-3,17,21-Trihydroxy-pregnane-11,20-dione
Additional Names: Reichstein's substance Dehydro-C; 11-dehydro C; allopregnane-3a,17a,21-triol-11,20-dione
Percent Composition: C 69...
Literature References: Isoln from beef adrenals: v. Euw et al., Helv. Chim. Acta 41, 1516 (1958). Synthesis of the 3a,21-diacetate: Nagata et al., ibid. 42, 1399 (1959).

Hydrallostane CAS Registry Number: 516-41-6 11-Beta,17-alpha,21-三羟基-5-alpha-孕烯-3,20-二酮

CAS Name: (5a,11b)-11,17,21-Trihydroxypregnane-3,20-dione
Additional Names: 11b,17a,21-trihydroxyallopregnane-3,20-dione; allodihydrohydrocortisone; allopregnane-11b,17a,21-triol-3,20-dione; 4,...
Literature References: Isoln from beef and hog adrenals: Neher, Wettstein, Helv. Chim. Acta 39, 2062 (1956). Prepn: Pataki et al., J. Biol. Chem. 195, 753 (1952); Fukushima, Daum, J. Org. Chem. 26, 520 (1961); Gould, Oliveto, US 2783254; US 2897216 (1957; 1959 to Schering); Gould, Herzog, US 2783226 (1957 to Schering); GB 742888 (1956 to Syntex).

Boldine CAS Registry Number: 476-70-0 波尔定碱

CAS Name: 5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol
Additional Names: 1,10-dimethoxy-6aa-aporphine-2,9-diol; 1,10-dimethoxy-2,9-dihydroxyaporphine; 2,6-dihy...
Literature References: Isoln from boldo (Peumus boldus Molina, Monimiaceae): Bourgoin, Verne, J. Pharm. Chim. 16, 191 (1872); from Laurelia novaezelandiae A. Cunn.: Bernauer, Helv. Chim. Acta 50, 1583 (1967). Structure: Warnat, Ber. 58, 2768; 59, 85 (1926); Späth, Tharrer, ibid. 66, 904 (1933); Schlittler, ibid. 988. Synthesis of dl-form: S. M. Kupchan et al., Chem. Commun. 1976, 91. Biosynthetic study: D. S. Bhakuni et al., J. Chem. Soc. Perkin Trans. 1 1977, 706. Detailed description of the boldo brush, its ingredients and pharmacological properties: H. Schindler, Arzneim.-Forsch. 7, 747 (1957).

Buphanamine CAS Registry Number: 6793-24-4

CAS Name: (1a)-2,3-Didehydro-7-methoxycrinan-1-ol
Percent Composition: C 67.76%, H 6.36%, N 4.65%, O 21.24%
Literature References: Isoln from bulb of Buphane (Boöphane) disticha Herb., Appleg. (Haemanthus toxicarius Herb.) Amaryllidaceae: Humber, Taylor, Can. J. Chem. 33, 1268 (1955); Hauth, Stauffacher, Helv. Chim. Acta 44, 491 (1961). From B. fischeri Baker: Renz et al., ibid. 38, 1209 (1955). Identity with "oily" haemanthine: Goosen, Warren, J. Chem. Soc. 1960, 1094. Structure and stereochemistry: Fales, Wildman, J. Org. Chem. 26, 881 (1961). Revised structure: Wildman in The Alkaloids vol. XI, R. H. F. Manske, Ed. (Academic Press, New York, 1968) p 361. NMR of revised structure: Crain et al., J. Am. Chem. Soc. 93, 990 (1971). High-resolution mass spectrum: P. Longevialle et al., Org. Mass Spectrom. 7, 401 (1973).

Chlorogenin CAS Registry Number: 562-34-5

CAS Name: (3b,5a,6a,25R)-Spirostan-3,6-diol
Percent Composition: C 74.96%, H 10.25%, O 14.79%
Literature References: Isoln from bulbs of the California soap plant, amole: Chlorogalum pomeridianum (DC.) Kunth, Liliaceae: Liang, Noller, J. Am. Chem. Soc. 57, 525 (1935). Chlorogenin occurs in amole as a saponin which kills or stuns fish without rendering them inedible. Structure: Marker, Rohrmann, ibid. 61, 947, 3479 (1939); Marker et al., ibid. 62, 2537, 3006 (1940). On hydrogenation the 3b,6b-isomer (b-chlorogenin) is produced.

Chondrocurine CAS Registry Number: 477-58-7

CAS Name: 6,6'-Dimethoxy-2,2'-dimethyltubocuraran-7',12'-diol
Additional Names: d-chondocurine; d-tubocurine
Percent Composition: C 72.71%, H 6.44%, N 4.71%, O 16.14%
Literature References: Isoln from Chondodendron tomentosum Ruiz Pav., Menispermaceae: Wintersteiner, Dutcher, Science 97, 467 (1943); King, J. Chem. Soc. 1948, 1945; Bick, Clezy, ibid. 1960, 2402; Boissier et al., Lloydia 28, 191 (1965), C.A. 64, 948b (1966). Structure: Dutcher, J. Am. Chem. Soc. 68, 419 (1946); Hultin, Acta Chem. Scand. 15, 1130 (1961). Configuration: Bick, Clezy, J. Chem. Soc. 1953, 3893; Hultin, Acta Chem. Scand. 17, 753 (1963). Revised structure: Everett et al., Chem. Commun. 1970, 1020. 13C-NMR: L. Koike et al., J. Org. Chem. 46, 2385 (1981).

Quinovin CAS Registry Number: 53516-73-7

Additional Names: Quinova-bitter; chinovin
Literature References: Isoln from cinchona bark (cortex chinae): Hlasiwetz, Ann. 111, 182 (1859); Liebermann, Giesel, Ber. 16, 926 (1883). A mixture of three glycosides, 60% A, 5% B and 30% C: Tschesche et al., Ann. 667, 151 (1963).

Quinovose CAS Registry Number: 7658-08-4 6-脱氧-D-葡萄糖

CAS Name: 6-Deoxy-D-glucose
Additional Names: D-glucomethylose; D-isorhamnose; D-epirhamnose; isorhodeose; epifucose; chinovose
Percent Composition: C 43.90%, H 7.37%, O 48.73%
Literature References: Isoln from cinchona bark: Freudenerg, Ber. 62, 373 (1929). Identity with D-glucomethylose: Votocek, Rác, Collect. Czech. Chem. Commun. 1, 239 (1929). Structure: Karrer, Boettcher, Helv. Chim. Acta 36, 570 (1953). Synthesis from 6-O-p-tolylsulfonyl-D-glucose: Schmidt, "6-Deoxy-a-D-glucose" in Methods in Carbohydrate Chemistry vol. I, R. L. Whistler, M. L. Wolfrom, Eds. (Academic Press, New York, 1962) pp 198-201. Alternate facile synthesis: V. K. Srivastava, L. M. Lerner, Carbohydr. Res. 64, 263 (1978).