其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Allopregnan-3 b -ol-20-one CAS Registry Number: 516-55-2 别孕烯醇酮

CAS Name: (3b,5a)-3-Hydroxypregnan-20-one
Additional Names: 3b-hydroxy-20-oxo-5a-pregnane
Percent Composition: C 79.19%, H 10.76%, O 10.05%
Literature References: Isoln from adrenal cortex: von Euw, Reichstein, Helv. Chim. Acta 24, 885 (1941); from corpus luteum: Butenandt, Mamoli, Ber. 68, 1847 (1935); Prelog, Meister, Helv. Chim. Acta 32, 2435 (1949); from human pregnancy urine: Lieberman et al., J. Biol. Chem. 172, 263 (1948); from human placenta: Pearlman, Cerceo, ibid. 194, 807 (1952). Prepn from 20-methyl-D20-allopregnen-3b-ol: Koechlin, Reichstein, Helv. Chim. Acta 27, 549 (1944); from pregnenolone: Mancera et al., J. Org. Chem. 16, 192 (1951); Pappas, Nace, J. Am. Chem. Soc. 81, 4556 (1959); by redn of allopregnane-3,20-dione with sodium borohydride: Mancera et al., ibid. 75, 1286 (1953); from progesterone 20-cycloethylene ketal: Sondheimer, Klibansky, Tetrahedron 5, 15 (1959).

Allopregnane-3 b ,11 b ,17 a ,21-tetrol-20-one CAS Registry Number: 651-43-4 5α-孕烷-3β,11β,17α,21-四醇-20-酮

CAS Name: 3b,11b,17,21-Tetrahydroxy-5a-pregnan-20-one
Additional Names: 3b,11b,17,21-tetrahydroxy-20-oxo-5a-pregnane; Reichstein's substance V
Percent Composition: C 68.82%, H 9.35%, O 21.83...
Literature References: Isoln from adrenal cortex: von Euw, Reichstein, Helv. Chim. Acta 25, 988 (1942). Prepn from 5a-pregnan-3b-ol-11,20-dione: Chamberlin, Chemerda, J. Am. Chem. Soc. 77, 1221 (1955); by hydrogenation of cortisol with rhodium: Caspi, J. Org. Chem. 24, 669 (1959); from bismethylenedioxyhydrocortisone: Fukushima, Daum, ibid. 26, 520 (1961).

Allopregnane-3 b ,17 a -diol-20-one CAS Registry Number: 570-54-7 3-beta,17-alpha-二羟基-5-alpha-孕甾烷-20-酮

CAS Name: (3b,5a)-3,17-Dihydroxypregnan-20-one
Additional Names: 3b,17-dihydroxy-5a-pregnan-20-one; 3b,17-dihydroxy-20-oxo-5a-pregnane; 17-(1-ketoethyl)androstane-3,17-diol; Reichstein's substa...
Literature References: Isoln from adrenal cortex: Wintersteiner, Pfiffner, J. Biol. Chem. 116, 291 (1936). Structure: Reichstein, Gätzi, Helv. Chim. Acta 21, 1497 (1938). Prepn from allopregnan-3b-ol-20-one 3-acetate: Rosenkranz et al., J. Am. Chem. Soc. 72, 4081 (1950); from pregn-5-ene-3b-ol-20-one: Ramirez, Stafie, ibid. 77, 134 (1955).

Allopregnane-3 b ,21-diol-11,20-dione CAS Registry Number: 566-02-9 别孕甾烷-3beta,21-二醇-11,20-二酮

CAS Name: 3b,21-Dihydroxy-5a-pregnane-11,20-dione
Additional Names: 3b,21-dihydroxy-11,20-dioxo-5a-pregnane; Kendall's compound H; Reichstein's substance N
Percent Composition: C 72.38%, H 9...
Literature References: Isoln from adrenal glands: Steiger, Reichstein, Helv. Chim. Acta 21, 546 (1938). Prepn by reduction of allopregnan-21-ol-3,11,20-trione acetate: Mancera et al., J. Am. Chem. Soc. 77, 5669 (1955).

Allopregnane-3 b ,17 a ,20 a -triol CAS Registry Number: 570-50-3 (3beta,5alpha,20S)-孕甾烷-3,17,20-三醇

CAS Name: 5a-Pregnane-3b,17,20a-triol
Additional Names: 3b,17,20a-trihydroxy-5a-pregnane; Reichstein's substance O
Percent Composition: C 74.95%, H 10.78%, O 14.26%
Literature References: Isoln from adrenal glands: Steiger, Reichstein, Helv. Chim. Acta 21, 546 (1938). Prepn from allopregn-16-en-3b-ol-20-one: Plattner et al., ibid. 31, 2210 (1948); Julian et al., US 2662904 (1953 to Glidden).

Allopregnane-3 b ,17 a ,21-triol-20-one CAS Registry Number: 516-47-2

CAS Name: 3b,17,21-Trihydroxy-5a-pregnan-20-one
Additional Names: 3a,17,21-trihydroxy-20-oxo-5a-pregnane; Reichstein's substance P
Percent Composition: C 71.96%, H 9.78%, O 18.26%
Literature References: Isoln from adrenal glands: Steiger, Reichstein, Helv. Chim. Acta 21, 546 (1938); Reichstein, Gatzi, ibid. 1185. Partial synthesis from cholesterol: Reichstein, von Euw, ibid. 24, 401 (1941). Prepn from allopregnan-3b-ol-20-one: Rosenkranz et al., J. Am. Chem. Soc. 72, 4081 (1950); from 3b-acetoxy-21-bromo-17a-hydroxy-2-oxoallopregnane: Kaufmann et al., US 2596562 (1952 to Syntex).

Pteropterin CAS Registry Number: 89-38-3

CAS Name: N-[N-[N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl]-L-glutamyl]-L-glutamic acid
Additional Names: N-[N-(N-pteroyl-g-glutamyl)-g-glutamyl]glutamic ...
Literature References: Isoln from aerobic culture of Corynebacterium: Hutchings et al., J. Am. Chem. Soc. 70, 1 (1948). Identification, structure and synthesis: Boothe et al., ibid. 1099; ibid. 71, 2304 (1949). Prepn: Cosulich, US 2563707 (1951 to Am. Cyanamid).

Amarolide CAS Registry Number: 29913-86-8 臭椿苦内酯

CAS Name: (2a,11a)-2,11-Dihydroxypicrasane-1,12,16-trione
Percent Composition: C 65.91%, H 7.74%, O 26.34%
Literature References: Isoln from Ailanthus altissima (Mill.) Swingle (A. glandulosa Desf.), Simaroubaceae, and proposed structure: Casinovi et al., Tetrahedron Lett. 1965, 2273. Isoln from Castela nicholsoni Hook, Simaroubaceae, and revised structure: Stöcklin et al., ibid. 1970, 2399.

Digallic Acid CAS Registry Number: 536-08-3 间双没食子酸

CAS Name: 3,4-Dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]benzoic acid
Additional Names: gallic acid 5,6-dihydroxy-3-carboxyphenyl ester; 4,5-dihydroxybenzoic acid monogallate; gallic acid 3-mono...
Literature References: Isoln from Aleppo gallotannin and Chinese gallotannin: Nierensten, Ber. 43, 628 (1910). Synthesis: Fischer, Freudenberg, Ber. 46, 1128 (1913). Structure: Nierenstein et al., J. Am. Chem. Soc. 47, 846 (1925). Determn by HPLC: P. Delahaye, M. Verzele, J. Chromatogr. 265, 363 (1983); in tannic acids: M. Verzele et al., Bull. Soc. Chim. Belg. 92, 181 (1983). Role in corrosion inhibition: A. M. Beccaria, E. D. Mor, Br. Corrosion J. 11, 156 (1976).

a -Methylene Butyrolactone CAS Registry Number: 547-65-9 α-亚甲基-γ-丁内酯

CAS Name: 4,5-Dihydro-3-methylene-2(3H)-furanone
Percent Composition: C 61.22%, H 6.16%, O 32.62%
Literature References: Isoln from aq extracts of Erythronium americanum Ker., Liliaceae (dogtooth violet): Cavallito, Haskell, J. Am. Chem. Soc. 68, 2332 (1946).