其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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FITC CAS Registry Number: 27072-45-3 (isomeric mixture); 3326-32-7 (5-isothiocyanate); 18861-78-4 (6-isothiocyanate)

CAS Name: 3',6'-Dihydroxy-5(or 6)-isothiocyanatospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one
Additional Names: fluorescein isothiocyanate
Percent Composition: C 64.78%, H 2.85%, N 3.60%, ...
Literature References: Isomeric mixture of the 5- and 6-isothiocyanates; structural analog of the fluorochrome, fluorescein, q.v. Prepn: A. H. Coons et al., J. Immunol. 45, 159 (1942); J. L. Riggs et al., J. Am. Pathol. 34, 1081 (1958). Determn of purity of commerical product: R. M. McKinney et al., Anal. Biochem. 7, 74 (1964); of properites and binding stoichiometry: A. Jobbágy, G. M. Jobbágy, J. Immunol. Methods 2, 159, 169 (1972). Quantitative determn of bound FITC: H. G. de Bruin et al., Vox Sang. 45, 373 (1983). Use as a pH probe: E. Lanz et al., J. Fluorescence 7, 317 (1997); and evaluation of protonation kinetics: J. Widengren et al., Chem. Phys. 249, 259 (1999). Immunofluorescent dye for microscopy: A. Entwistle, M. Noble, J. Microsc. 168, 219 (1992). Label for amino acids: K. Muramoto et al., Meth. Protein Seq. Anal. 1993, 29; F. Dang, Y. Chen, Sci. China B 42, 663 (1999). Detection of anionic detergents: H.-W. Gao, D.-Y. Zhou, Bull. Korean Chem. Soc. 23, 29 (2002).

Allocryptopine CAS Registry Number: 485-91-6 别隐品碱

CAS Name: 5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methylbenzo[e][1,3]dioxolo[4,5-k][3]benzazecin-14(6H)-one
Percent Composition: C 68.28%, H 6.28%, N 3.79%, O 21.66%
Literature References: Isomeric with cryptopine, q.v. Obtained from Chelidonium majus L., Bocconia cordata Willd., Sanguinaria canadensis L. and allied Papaveraceae: Manske in Manske, Holmes, The Alkaloids vol. IV (Academic Press, New York, 1954) p 159. Structure: Gadamer, Arch. Pharm. 257, 298 (1919). Exists in two isomeric modifications designated as a- and b-forms. Identity of a-form with a-fagarine: Redemann et al., J. Am. Chem. Soc. 71, 1030 (1949). Synthesis: Haworth, Perkin, J. Chem. Soc. 1926, 445; Bentley, Murray, ibid. 1963, 2497.

Lycoctonine CAS Registry Number: 26000-17-9

CAS Name: (1a,6b,14a,16b)-20-Ethyl-4-(hydroxymethyl)-1,6,14,16-tetramethoxyaconitane-7,8-diol
Additional Names: royline
Percent Composition: C 64.21%, H 8.84%, N 3.00%, O 23.95%
Literature References: Isomeric with delsoline. Originally isolated from Aconitum lycoctonum L., Ranunculaceae: Hubschmann, Schweiz. Wochschr. Pharm. 3, 269 (1865). Widely distributed in Aconitum and Delphinium spp., Ranunculaceae. Structure: Edwards et al., Can. J. Chem. 34, 1315 (1956); Anet et al., ibid. 35, 400 (1957). Identity with royline: Edwards, Rodger, ibid. 37, 1187 (1959). Stereochemistry: Przybylska, Marion, ibid. 1843. Revised configuration: S. W. Pelletier et al., J. Am. Chem. Soc. 103, 6536 (1981).

Iodophthalein Sodium CAS Registry Number: 2217-44-9

Additional Names: Soluble iodophthalein; tetraiodophenolphthalein sodium; T.I.P.P.S.; tetraiodophthalein sodium; tetiothalein sodium
Trademarks: Iodeikon (Mallinckrodt); Cholepulvis; Keraphen; ...
Literature References: Isomeric with phentetiothalein sodium, q.v. Prepd by the action of iodine (in KI soln) on phenolphthalein in aq alk soln: Classen, Löb, Ber. 28, 1603 (1895); DE 85930 (1894); DE 88390 (1895). Also obtained by treating an alk soln of phenolphthalein with iodine monochloride: Kalle, DE 143596 (1900). Prepn of free acid: Orndorff, Mahood, J. Am. Chem. Soc. 40, 937 (1918). Toxicity data: J. O. Hoppe et al., J. Med. Chem. 13, 997 (1970). Metabolism in rabbits: D. Pitre, L. Fumagalli, Farmaco Ed. Sci. 32, 76 (1977).

Tosylmethyl Isocyanide CAS Registry Number: 36635-61-7 对甲基苯磺酰甲基异腈

CAS Name: 1-[(Isocyanomethyl)sulfonyl]-4-methylbenzene
Additional Names: (4-methylphenylsulfonyl)methyl isocyanide; p-toluenesulfonylmethyl isocyanide; TosMIC
Percent Composition: C 55.37%, ...
Literature References: Isonitrile reagent with reversed polarity; serves as a carbonyl anion equivalent in organic synthesis. Prepn: U. Schöllkopf et al., Ann. 766, 130 (1972); A. M. van Leusen et al., Tetrahedron Lett. 13, 2367 (1972); B. E. Hoogenboom et al., Org. Synth. 57, 102 (1977). Review of applications in organic synthesis: C. Lamberth, J. Prakt. Chem. Chem.-Ztg. 340, 483-485 (1998); V. K. Tandon, S. Rai, Sulfur Rep. 24, 307-385 (2003).

Galegine CAS Registry Number: 543-83-9 2-(3-甲基丁2-Enyl)胍

CAS Name: (3-Methyl-2-butenyl)guanidine
Additional Names: N-3,3-dimethylallylguanidine; isoamyleneguanidine
Percent Composition: C 56.66%, H 10.30%, N 33.04%
Literature References: Isoprenoid guanidine deriv from seeds of Galega officinalis L., Leguminosae: Tanret, Compt. Rend. 158, 1182, 1426 (1914); 159, 108 (1914); Markovic, Dittertová, Chem. Zvesti 9, 576 (1955), C.A. 50, 8137d (1956). Structure: Barger, White, Biochem. J. 17, 827 (1923). Synthesis: Späth, Spitzy, Ber. 58, 2273 (1925); Babor, Jezo, Chem. Zvesti 8, 18 (1954), C.A. 49, 7495f (1955). Metabolic effects: G. Weitzel et al., Z. Physiol. Chem. 353, 535 (1972). Effects on mitochondria: B. Lotina et al., Arch. Biochem. Biophys. 159, 520 (1973). Biosynthetic study: J. Steiniger, G. Reuter, Biochem. Physiol. Pflanz. 166, 275 (1974). Review: Braun, J. Chem. Educ. 8, 2175 (1931).

Sodium Phosphate, Monobasic CAS Registry Number: 7558-80-7 磷酸二氢钠

Additional Names: Sodium biphosphate; sodium dihydrogen phosphate; acid sodium phosphate; monosodium orthophosphate; primary sodium phosphate
Percent Composition: H 1.68%, Na 19.16%, O 53.34%, ...
Literature References: It is about 99% pure.

Ammonium Benzoate CAS Registry Number: 1863-63-4 苯甲酸铵

CAS Name: Benzoic acid, ammonium salt
Percent Composition: C 60.42%, H 6.52%, N 10.07%, O 23.00%
Literature References: It is about 99% pure. Manuf from benzoic acid and NH3: Spina, US 1704636 (1929 to Hooker Electrochem.).

Zinc p-Phenolsulfonate CAS Registry Number: 127-82-2 苯酚磺酸锌

CAS Name: p-Hydroxybenzenesulfonic acid zinc salt
Additional Names: 1-phenol-4-sulfonic acid zinc salt; zinc p-hydroxybenzenesulfonate; zinc sulfocarbolate; zinc sulfophenate
Trademarks: Phe...
Literature References: It is at least 99.5% pure. Prepn: Rojahn, Dtsch. Apoth. Ztg. 50, 1095 (1935), C.A. 31, 68168 (1937).

Phenallymal CAS Registry Number: 115-43-5 苯烯比妥

CAS Name: 5-Phenyl-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-allyl-5-phenylbarbituric acid; 5-phenyl-5-allylbarbituric acid; phenallymalum; alphenal; prophenal
Trad...
Literature References: Its methods of prepn are similar to those used for phenobarbital: Slotta, Grundriss der modernen Arzneistoff-Synthese (Stuttgart, 1931) p 45. Metabolism: D. J. Harvey et al., Res. Commun. Chem. Pathol. Pharmacol. 4, 247 (1972); eidem, Drug Metab. Dispos. 5, 527 (1977).