其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Anagyrine CAS Registry Number: 486-89-5 安纳基林

CAS Name: [7R-(7a,7ab,14a)]-7,7a,8,9,10,11,13,14-Octahydro-7,14-methano-4H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocin-4-one
Additional Names: monolupine; rhombinin
Percent Composition: C 73.74%...
Literature References: Found in seeds of Anagyris foetida L., Leguminosae and in gorse (Ulex europaeus L., Leguminosae). Isoln: Ing, J. Chem. Soc. 1933, 504; Orekhov et al., Ber. 67, 1394 (1934); Couch, J. Am. Chem. Soc. 61, 3327 (1939); Briggs, Russell, J. Chem. Soc. 1942, 507; Galinsky, Stern, Ber. 77, 132 (1944); Faugeras, Ann. Pharm. Fr. 29, 241 (1971). Absolute configuration: Okuda et al., Chem. Ind. (London) 1961, 1116; Okuda et al., Chem. Pharm. Bull. 13, 491 (1965). Synthesis: van Tamelen, Baran, J. Am. Chem. Soc. 80, 4659 (1958); Goldberg, Lipkin, J. Org. Chem. 37, 1823 (1972).

Hematin CAS Registry Number: 15489-90-4 羟高铁血红素

CAS Name: (SP-5-13)-[7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]hydroxyferrate(2-) dihydrogen
Additional Names: [dihydrogen 3,7,12,17-tetramethy...
Literature References: Found in the body in pathological conditions, e.g., after phosgene poisoning, in pernicious anemia. Prepn: Fischer-Orth, Die Chemie des Pyrrols II, 1, 386 (Leipzig, 1937). Brief review including structure: J. E. Falk, Porphyrins and Metalloporphyrins (Elsevier, New York, 1964) pp 17, 23, 46. Toxicology: D. L. Lips et al., Toxicol. Lett. 2, 329 (1978). Use in treatment of hepatic porphyria: C. J. Watson et al., Ann. Intern. Med. 79, 80 (1973); G. J. Dhar et al., ibid. 83, 20 (1975); J. M. Lamon et al., Medicine 58, 252 (1979).

Albaspidin CAS Registry Number: 58409-52-2

CAS Name: 2,2'-Methylenebis[6-butyryl-3,5-dihydroxy-4,4-dimethyl-2,5-cyclohexadien-1-one]
Additional Names: polystichalbin; methylenebis(butyrylfilicinic acid); albaspidin-BB
Percent Composi...
Literature References: Found in the rhizomes of the male fern, Aspidium filix mas (L.) Schott., Dryopteris filix mas (L.) Schott., A. spinulosum, Polypodiaceae and other ferns. Isoln from Aspidium extract: Boehm, Ann. 318, 305 (1901); McGookin et al., J. Chem. Soc. 1953, 1828; see also Tryon et al., Phytochemistry 12, 683 (1973). Isoln as one component of a homologous mixture: Penttila, Sundman, Acta Chem. Scand. 18, 344 (1964). Synthesis: Riedl, Mitteldorf, Ber. 89, 2595 (1956); Inagaki et al., J. Pharm. Soc. Jpn. 76, 1258 (1956). Biosynthetic studies: Penttila, Fales, J. Am. Chem. Soc. 88, 2327 (1966).

Narcotoline CAS Registry Number: 521-40-4 [S-(R,R)]-6,7-二甲氧基-3-(5,6,7,8-四氢-4-羟基-6-甲基-1,3-二氧杂环戊并[4,5-g]异喹啉-5-基)苯酞

CAS Name: (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
Additional Names: desmethylnarcotine
Percent Composition...
Literature References: Found in the shell of ripe poppyseed capsules: Wrede, Arch. Pharmacol. 184, 331 (1937); Baumgarten, Christ, Pharmazie 5, 80 (1950); Pfeifer, Weiss, ibid. 10, 658 (1955); from opium prepns: Pfeifer, Arch. Pharm. 290, 209 (1957). Preliminary stereochemical studies: Battersby, Spenser, J. Chem. Soc. 1965, 1087. Revised stereochemistry: Blaha et al., Collect. Czech. Chem. Commun. 29, 2328 (1964); Snatzke et al., Tetrahedron 25, 5059 (1969).

Glycosine CAS Registry Number: 6873-15-0 山小橘碱

CAS Name: 1-Methyl-2-(phenylmethyl)-4(1H)-quinazolinone
Additional Names: 2-benzyl-1-methylquinazol-4-one; arborine
Percent Composition: C 76.78%, H 5.64%, N 11.19%, O 6.39%
Literature References: Found in the toothbrush plant, Glycosmis pentaphylla (Retz.) Corr., and G. arborea Corr., Rutaceae. Isoln from dried, powdered leaves: Chatterjee, Majumdar, J. Am. Chem. Soc. 76, 2459 (1954). Identity of arborine and glycosine, structure: Chakravarti et al., Tetrahedron 16, 224 (1961). Synthesis: Pakrashi et al., Indian J. Chem. 6, 472 (1968); Ziegler et al., Monatsh. Chem. 100, 948 (1969); T. Kametani et al., Heterocycles 9, 1585 (1978).

Dioscorine CAS Registry Number: 3329-91-7

CAS Name: [1R-(1a,4a,5a)]-2,4'-Dimethylspiro[2-azabicyclo[2.2.2]octane-5,2'-[2H]pyran]-6'(3'H)-one
Percent Composition: C 70.56%, H 8.65%, N 6.33%, O 14.46%
Literature References: Found in the tubers of Dioscorea hirsuta Blume and D. hispida Dennst., Dioscoreaceae: H. W. Schutte, Chem. Zentralbl. 68, II, 130 (1897); M. K. Gorter, Rec. Trav. Chim. 30, 161 (1911); A. R. Pinder, Nature 168, 1090 (1951); idem, J. Chem. Soc. 1952, 2236. Structure: W. A. M. Davies et al., Chem. Ind. (London) 1961, 1410; eidem, Tetrahedron 18, 405 (1962); Morris, A. R. Pinder, J. Chem. Soc. 1963, 1841. Synthesis: Page, A. R. Pinder, ibid. 1964, 4811. Absolute configuration: A. F. Beecham et al., Tetrahedron Lett. 1969, 3745. Biosynthetic studies: E. Leete, A. R. Pinder, Chem. Commun. 1971, 1499; E. Leete, J. Am. Chem. Soc. 99, 648 (1977). Pharmacology: A. R. Pinder, J. Chem. Soc. 1953, 1826. Evaluation of toxic components: J. Webster et al., J. Agric. Food Chem. 32, 1087 (1984).

Kynurenic Acid CAS Registry Number: 492-27-3 犬尿喹啉酸

CAS Name: 4-Hydroxy-2-quinolinecarboxylic acid
Additional Names: 4-hydroxyquinaldic acid
Percent Composition: C 63.49%, H 3.73%, N 7.40%, O 25.37%
Literature References: Found in the urine of some animals as a metabolic product of tryptophan; its excretion is stepped up in avitaminoses B1, B2 and B6. Isoln and syntheses: Späth, Monatsh. Chem. 42, 89 (1921); Besthorn, Ber. 54, 1330 (1921). Alternate syntheses: Benassi, Gazz. Chim. Ital. 91, 1097 (1961); Wald, Joullie, J. Org. Chem. 31, 3369 (1966); Jordanides, Ann. 729, 244 (1969).

Jasmone CAS Registry Number: 488-10-8 顺茉莉酮

CAS Name: 3-Methyl-2-(2-pentenyl)-2-cyclopenten-1-one
Percent Composition: C 80.44%, H 9.82%, O 9.74%
Literature References: Found in the volatile portion of oil from jasmine flowers. Natural jasmone is the cis-ketone. Isoln and structure: Ruzicka, Pfeiffer, Helv. Chim. Acta 16, 1208 (1933). Stereochemistry: Crombie, Harper, J. Chem. Soc. 1952, 869. Synthesis of cis-jasmone: H. Hunsdiecker, Ber. 75, 447 (1942); Stork, Borch, J. Am. Chem. Soc. 86, 936 (1964); Büchi, Wuest, J. Org. Chem. 31, 977 (1966); Sakan et al., Chem. Lett. 1973, 713; P. Bakuzis, M. L. F. Bakuzis, J. Org. Chem. 42, 2362 (1977). Synthesis of dihydrojasmone and cis-jasmone: C. S. Subramaniam et al., J. Chem. Soc. Perkin Trans. 1 1979, 2346; T. Kato et al., Chem. Pharm. Bull. 28, 349 (1980). Synthesis of trans-jasmone: Sisido et al., J. Org. Chem. 29, 2290 (1964). Comprehensive synthetic reviews: R. A. Ellison, Synthesis 1973, 397; T. L. Ho, Synth. Commun. 4, 265 (1974).

Taraxerol CAS Registry Number: 127-22-0 蒲公英赛醇

CAS Name: (3b)-D-Friedoolean-14-en-3-ol
Additional Names: isoolean-14-en-3b-ol; skimmiol; alnulin; tiliadin
Percent Composition: C 84.44%, H 11.81%, O 3.75%
Literature References: Found in Tilia cordata Mill., Tiliaceae: Bräutigam, Arch. Pharm. 238, 555 (1900); in Alnus glutinosa (L.) Gaertn., Betulaceae: Zellner, Weiss, Sitzungsber. Akad. Wiss. Wien 132, 258 (1923); in Taraxacum officinale Weber, Compositae: Burrows, Simpson, J. Chem. Soc. 1938, 2042; in Litsea dealbata Nees, Lauraceae: Dunstan et al., Aust. J. Chem. 6, 321 (1953); from Befaria racemosa (Vent.), Ericaceae: Euda et al., J. Org. Chem. 26, 271 (1961). Structure: Beaton et al., J. Chem. Soc. 1955, 2131. Partial synthesis from b-amyrin: eidem, Chem. Ind. (London) 1955, 35.

Pyrrolidine CAS Registry Number: 123-75-1 四氢吡咯

Additional Names: Tetrahydropyrrole
Percent Composition: C 67.55%, H 12.76%, N 19.69%
Literature References: Found in tobacco and carrot leaves. Probable biosynthesis from ornithine and putrescine. Usually prepd by reduction of pyrrole.