其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

D -Glucuronolactone CAS Registry Number: 32449-92-6 D-葡萄糖醛酸内酯

CAS Name: D-Glucuronic acid g-lactone
Additional Names: D-glucofuranurono-6,3-lactone; glucurolactone; glucurone
Trademarks: Dicurone; Glucoxy; Guronsan
Percent Composition: C 40.92%, H 4...
Literature References: Found in many plant gums in polymeric combination with other carbohydrates. Important structural constituent of practically all fibrous and connective tissues in the animal organism, cf. D-glucuronic acid. Prepd synthetically from many polysaccharides or suitable glucosides where the hydroxyl at carbon 6 may be oxidized while the other sensitive groups are protected. Prepn: Stacey, J. Chem. Soc. 1939, 1529; Hardegger, Spitz, Helv. Chim. Acta 33, 337 (1950); Marsh, Proc. Biochem. Soc. [Biochem. J.], 50, XI (1951); Mehltretter et al., J. Am. Chem. Soc. 73, 2424 (1951); Phillips, Moody, J. Chem. Soc. 1960, 762. Structure: J. Stanek et al., The Monosaccharides (Academic Press, New York, 1963) p 259. For isoln procedures see the ref under glucuronic acid.

Dihydroactinidiolide CAS Registry Number: 15356-74-8 二氢猕猴桃内酯

CAS Name: 5,6,7,7a-Tetrahydro-4,4,7a-trimethyl-2(4H)-benzofuranone
Additional Names: 2-oxo-4,4,7a-trimethyl-2,4,5,6,6,7a-hexahydrobenzofuran; (2,6,6-trimethyl-2-hydroxycyclohexylidene)acetic ac...
Literature References: Found in many plant sources including tea and tobacco. (-)-Form is naturally occurring. Produced by photo-oxidation of carotenoid flavor compounds. Pheromone component for queen recognition in red fire ants. Isoln from black tea aroma: J. Bricout et al., Helv. Chim. Acta 50, 1517 (1967); from Actinidia polygama Miq. and structure determn: T. Sakan et al., Tetrahedron Lett. 8, 1623 (1967); from tobacco and synthesis: W. C. Bailey, Jr. et al., J. Org. Chem. 33, 2819 (1968). Synthesis: S. Isoe et al., Tetrahedron Lett. 9, 5561 (1968); by photo-oxidation of b-carotene: eidem, ibid. 10, 279 (1969). Abs config study: eidem, ibid. 13, 2517 (1972). Prepn of enantiomers: K. Mori, Y. Nakazono, Tetrahedron 42, 283 (1986). Improved prepns: G. V. Subbaraju et al., Tetrahedron Lett. 32, 4871 (1991); A. Bosser et al., Biotechnol. Prog. 11, 689 (1995). Prepn of (R)-form: S. Yao et al., J. Org. Chem. 63, 118 (1998). Germination inhibition in wheat grains: T. Kato et al., J. Agric. Food Chem. 51, 2161 (2003).

Luteolin CAS Registry Number: 491-70-3 木犀草素; 3',4',5,7-四羟基黄酮

CAS Name: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
Additional Names: 3',4',5,7-tetrahydroxyflavone; digitoflavone; cyanidenon 1470
Percent Composition: C 62.94%, H 3.52%, ...
Literature References: Found in many plants in glycosidic combination, e.g., as the arabinoside: Perkin, J. Chem. Soc. 69, 800 (1896); Fleischer, Ber. 32, 1186 (1899); Perkin, Horsfall, J. Chem. Soc. 77, 1315 (1900); Hayashi, Inoue, Acta Phytochim. 15, 53 (1949); C.A. 43, 8450 (1949). Identity with digitoflavone: Kiliani, Mayer, Ber. 34, 3577 (1901). Synthesis: Hutchins, Wheeler, J. Chem. Soc. 1939, 91. See also Bioflavonoids.

Hydrocotarnine CAS Registry Number: 550-10-7 氢化鸟嘌呤

CAS Name: 5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline
Additional Names: 8-methoxy-5,6-methylenedioxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
Percent Composition: C 6...
Literature References: Found in mother liquors from morphine extraction. It is not certain whether it is formed from narcotine during the extraction or whether it exists in the poppy plant. May also be prepd by reduction of cotarnine: Topchiev, J. Appl. Chem. USSR 6, 529 (1933), C.A. 28, 2718 (1934); Schneider, Müller, Ann. 615, 34 (1958); Knabe, Arch. Pharm. 292, 652 (1959). Reduction of hydrocotarnine with sodium in alcohol leads to replacement of the methoxyl group by hydrogen, with formation of hydrohydrastinine. Review and bibliography: Small, Lutz, "Chemistry of the Opium Alkaloids," Suppl. No. 103, Public Health Reports, Washington (1932).

Sodium Sesquicarbonate CAS Registry Number: 533-96-0 碳酸钠盐(2:3)

Additional Names: Urao; trona
Percent Composition: C 12.64%, H 0.53%, Na 36.30%, O 50.52%
Literature References: Found in nature as the dihydrate, e.g., Owens Lake, Searles Lake (U.S.A.); Lake Magadi (Kenya). Produced on a large scale from sodium carbonate and a slight excess of sodium bicarbonate: Schenk in Winnacker-Weingaertner, Chemische Technologie vol. I (München, 1950) p 427.

Pulegone CAS Registry Number: 89-82-7 蒲勒酮, 胡薄荷酮,长叶薄荷酮

CAS Name: (5R)-5-Methyl-2-(1-methylethylidene)cyclohexanone
Additional Names: R-(+)-p-menth-4(8)-en-3-one; 1-methyl-4-isopropylidene-3-cyclohexanone
Percent Composition: C 78.90%, H 10.59%, ...
Literature References: Found in oils derived from plants of the Labiatae family as (+)-form. Readily isolated in quantity from the pennyroyal oils from Mentha pulegium L., M. longifolia (L.) Huds., and Hedeoma pulegioides (L.) Pers., Labiatae: Gildemeister, Hoffmann, Die ätherischen Ole Vol. I, p 560 (1928); Simonsen, The Terpenes Vol. I (2nd ed, 1947) p 370. Synthesis: Kuhn, Schinz, Helv. Chim. Acta 36, 161 (1953). Synthesis of the (±)-form: Black et al., J. Chem. Soc. 1956, 2971; Wolinsky et al., J. Org. Chem. 30, 3207 (1965); of the S(-)-form: E. J. Corey et al., ibid. 41, 380 (1976). Improved synthesis of the R(+)-form: T. Sato et al., Tetrahedron Lett. 1980, 3377. Conversion of the R(+) to the S(-)-form: H. E. Ensley, R. V. C. Carr, ibid. 1977, 513. Biosynthetic study: A. Akhila, D. V. Banthorpe, Z. Pflanzenphysiol. 99, 277 (1980), C.A. 94, 2073r (1981).

Hemipyocyanine CAS Registry Number: 528-71-2 1-羟基吩嗪

CAS Name: 1-Phenazinol
Additional Names: a-hydroxyphenazine; 1-hydroxy-5,10-diazoanthracene; pyoxanthose
Percent Composition: C 73.46%, H 4.11%, N 14.28%, O 8.15%
Literature References: Found in old cultures of Pseudomonas pyocyanea. Isoln: Fordos, Compt. Rend. 56, 1128 (1863). Prepd from pyocyanine by the action of 2% NaOH: Wrede, Strack, Z. Physiol. Chem. 140, 12 (1924); by the reaction of pyrogallol monomethyl ether and o-phenylenediamine followed by demethylation of the formed a-methoxyphenazine: Surrey, Org. Synth. coll. vol. III, 753 (1955). Alternate syntheses: Hegedüs, Helv. Chim. Acta 33, 766 (1950); Vivian, Nature 178, 753 (1956).

Pimpinellin CAS Registry Number: 131-12-4 茴芹内酯

CAS Name: 5,6-Dimethoxy-2H-furo[2,3-h]-1-benzopyran-2-one
Additional Names: 4-hydroxy-6,7-dimethoxy-5-benzofuranacrylic acid d-lactone
Percent Composition: C 63.41%, H 4.09%, O 32.49%
Literature References: Found in Pimpinella saxifraga L., Heracleum spondylium L., H. lanatum Michx., and H. panaces L., Umbelliferae. Isoln: Heut, Arch. Pharm. 236, 162 (1898); Herzog, Hancu, ibid. 246, 402 (1908); Wessely, Kallab, Monatsh. Chem. 59, 161 (1932); Späth, Simon, ibid. 67, 344 (1936); Fujita, Furuya, J. Pharm. Soc. Jpn. 74, 795 (1954); 76, 535 (1956); Svendsen, Ottestad, Pharm. Acta Helv. 32, 457 (1957); Svendsen, C.A. 52, 2173g (1958); Svendsen et al., Planta Med. 7, 113 (1959); Pharm. Acta Helv. 34, 33 (1959); Jastrzebski, C.A. 54, 1205b (1960). Synthesis: M. W. Reed, H. W. Moore, J. Org. Chem. 53, 4166 (1988).

Rescinnamine CAS Registry Number: 24815-24-5 利血那明

CAS Name: (3b,16b,17a,18b,20a)-11,17-Dimethoxy-18-[[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]oxy]-3,20-yohimban-16-carboxylic acid methyl ester
Additional Names: 3,4,5-trimethoxycinnamic aci...
Literature References: Found in Rauwolfia serpentina Benth., Apocynaceae: Haack et al., Naturwissenschaften 41, 214 (1954); Ordway, Guercio, US 2876228 (1959 to Pfizer); Klohs et al., US 2974144 (1961 to Riker); from Rauwolfia spp: Banes et al., J. Am. Pharm. Assoc. 47, 625 (1958). Identity with reserpinine: Haack et al., Naturwissenschaften 42, 47 (1955). Structure: Klohs et al., J. Am. Chem. Soc. 77, 2241 (1955). LC-ED determn in urine: J. Wang, M. Bonakdar, J. Chromatogr. 382, 343 (1986). LC determn in rauwolfia preparations: U. R. Cieri, J. AOAC Int. 81, 373 (1998).

Sempervirine CAS Registry Number: 6882-99-1 常绿钩吻碱

CAS Name: 2,3,4,13-Tetrahydro-1H-benz[g]indolo[2,3-a]quinolizin-6-ium
Additional Names: 3,4,5,6,14,15,20,21-octadehydroyohimbanium; sempervirene
Percent Composition: C 83.79%, H 5.92%, N 10....
Literature References: Found in rhizome and roots of Carolina jessamine (yellow jessamine) Gelsemium sempervirens (L.) Ait. f., Loganiaceae: Stevenson, Sayre, J. Am. Pharm. Assoc. 4, 60 (1915); 8, 708 (1919); Hasenfratz, Bull. Soc. Chim. Fr. [4] 53, 1084 (1933); Forsyth et al., J. Chem. Soc. 1945, 579; Prelog, Helv. Chim. Acta 31, 588 (1948). Believed to exist primarily as inner salt depicted below: Woodward, Witkop, J. Am. Chem. Soc. 71, 379 (1949). Synthesis: Woodward, McLamore, ibid. 379; Swan, J. Chem. Soc. 1958, 2039; Ban, Seo, Tetrahedron 16, 11 (1961); Potts, Mattingly, J. Org. Chem. 33, 3985 (1968).