其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Isanic Acid CAS Registry Number: 506-25-2 17-十八碳烯-9,11-二炔酸

CAS Name: 17-Octadecene-9,11-diynoic acid
Additional Names: bolecic acid; erythrogenic acid
Percent Composition: C 78.79%, H 9.55%, O 11.66%
Literature References: Found in vegetable oils obtained from tropical and equatorial regions. Isoln from boleko oil: De Vries, Oleagineux 12, 427 (1957); US 2789993 (1957 to UCB). Structure: Steger, Van Loon, Rec. Trav. Chim. 59, 1156 (1940); Gunstone, Sealy, J. Chem. Soc. 1963, 5772; Morris, ibid. 5779. Synthesis: Black, Weedon, ibid. 1953, 1785.

Ricinoleic Acid CAS Registry Number: 141-22-0 蓖麻油酸

CAS Name: (9Z,12R)-12-Hydroxy-9-octadecenoic acid
Additional Names: d-12-hydroxyoleic acid
Percent Composition: C 72.44%, H 11.48%, O 16.08%
Literature References: Found primarily in oils from the seeds of Ricinus spp, Euphorbiaceae. Accounts for about 90% of the triglyceride fatty acids of castor oil, and up to about 40% of the glyceride fatty acids of ergot oil. Bibliography on its isoln: Ralston, Fatty Acids (New York, 1948) p 189. Also isolated from Linum mucronatum (flax), Linaceae: Kleiman, Spencer, Lipids 6, 962 (1971). Structure: Goldsobel, Ber. 27, 3121 (1894). Mechanism of biosynthesis: Morris, Biochem. Biophys. Res. Commun. 29, 311 (1967).

Chavicol CAS Registry Number: 501-92-8 4-烯丙基苯酚

CAS Name: 4-(2-Propenyl)phenol
Additional Names: p-allylphenol; g-(p-hydroxyphenyl)-a-propylene
Percent Composition: C 80.56%, H 7.51%, O 11.92%
Literature References: Found together with terpenes in volatile betel oils (from leaves of Piper betle L., Piperaceae): Eijkman, Ber. 22, 2739 (1889). Prepd from a mixture of estragole, ethyl bromide and magnesium in benzene: Grignard, Compt. Rend. 151, 323 (1910); from 4-allylphenylmagnesium bromide in ether by the action of oxygen: Quelet, Bull. Soc. Chim. Fr. [4] 45, 265 (1929).

Neoquassin CAS Registry Number: 76-77-7 新苦木素

CAS Name: 16-Hydroxy-2,12-dimethoxypicrasa-2,12-diene-1,11-dione
Additional Names: 3a,4,5,6a,7,7a,8,11a,11b,11c-decahydro-5-hydroxy-2,10-dimethoxy-3,8,11a,11c-tetramethylphenanthro[10,1-bc]pyra...
Literature References: Found together with the quassin in the mixture of bitter constituents of the wood of Quassia amara L., Simaroubaceae, known in commerce as Surinam quassia. Forms quassin on oxidation. Isoln: London et al., J. Chem. Soc. 1950, 3431. Structure: Valenta et al., Tetrahedron Lett. 1960(20), 25; Carman, Ward, ibid. 1961, 317; Valenta et al., Tetrahedron 15, 100 (1961).

a -Glucose-1-phosphate CAS Registry Number: 59-56-3 对氟苯甲醇

CAS Name: a-D-Glucopyranose 1-dihydrogenphosphate
Additional Names: a-glucose-1-phosphoric acid; a-D-glucopyranose-1-phosphate; Cori ester
Percent Composition: C 27.70%, H 5.04%, O 55.35%, P...
Literature References: Found widely in both plants and animals. In plants it is the immediate precursor of starch, and in animals of glycogen, being also the first product in the breakdown and utilization of these substances. Isoln from muscle and synthesis using trisilver phosphate: Cori et al., J. Biol. Chem. 121, 465 (1937); Krahl, Cori, Biochem. Prep. 1, 33 (1949). Prepn from a-acetobromglucose + silver diphenyl phosphate: Posternak, J. Am. Chem. Soc. 72, 4824 (1950); by phosphorolysis of starch using phosphorylase and orthophosphate: McCready, Hassid, Biochem. Prep. 4, 63 (1955). Structure: Wolfrom, Pletcher, J. Am. Chem. Soc. 63, 1050 (1941). Configuration: Wolfrom et al., ibid. 64, 23 (1942); Harmon, Diss. Abstr. 24, 4400 (1964); Beevers, Maconochie, Acta Crystallogr. 18, 232 (1965).

Ceftobiprole Medocaril CAS Registry Number: 376653-43-9 头孢比普酯

CAS Name: (6R,7R)-7-[[(2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(hydroxyimino)acetyl]amino]-3-[(E)-[(3'R)-1'-[[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]carbonyl]-2-oxo[1,3'-bipyrrolidin]-3-ylidene]methyl...
Literature References: Fourth generation cephalosporin antibiotic prodrug; rapidly cleaved in plasma to the active metabolite, ceftobiprole. Prepn: P. Hebeisen et al., WO 9965920; eidem, US 6232306 (1999, 2001 both to Hoffmann-La Roche). In vitro and in vivo activity against methicillin-resistant Staphylococcus aureus (MRSA): idem et al., Antimicrob. Agents Chemother. 45, 825 (2001). Comparative antibacterial spectrum in vitro: R. N. Jones et al., J. Antimicrob. Chemother. 50, 915 (2002). In vivo activity in experimental pneumococcal pneumonia: E. Azoulay-Dupuis et al., Antimicrob. Agents Chemother. 48, 1105 (2004). Clinical pharmacokinetics and safety: A. Schmitt-Hoffmann et al., ibid. 48, 2576 (2004).

Cefpirome CAS Registry Number: 84957-29-9 头孢匹罗

CAS Name: 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-5H-cyclopenta[b]pyrindinium inner salt Literature References: Fourth generation cephalosporin antibiotic. Prepn: R. Lattrell et al., GB 2098216 (1982 to Hoechst). Prepn of crystalline salts: W. Dürckheimer, R. Lattrell, US 4609653 (1986 to Hoechst); and in vitro antibacterial activity: G. Seibert et al., Arzneim.-Forsch. 33, 1084 (1983). Physical properties: R. Lattrell et al., Proc. 13th Int. Congr. Chemother. 4, part 99, 1 (1983). Comparative in vitro antibacterial spectrum and b-lactamase stability: H. C. Neu et al., Infection 13, 146 (1985). HPLC determn in serum and urine: H. Uihlein et al., ibid. 16, 135 (1988). Clinical pharmacokinetics: J. Kavi et al., J. Antimicrob. Chemother. 22, 911 (1988). Series of articles on laboratory and clinical evaluations: ibid. 29, Suppl A 1-104 (1992). Toxicity studies: G. Horstmann, K. Engelbart, Arzneim.-Forsch. 40, 1250 (1990); H. H. Donaubauer, D. Mayer, J. Antimicrob. Chemother. 29, Suppl. A, 71 (1992).

Francium CAS Registry Number: 7440-73-5

Additional Names: Eka-cesium
Literature References: Fr; at. no. 87; valence 1. Group IA (1). No stable nuclides. Naturally occurring isotope: 223, Actinum K, (longest lived isotope, T½ 21.8 min, b- emitter; rel. at. mass 223.0197) formed by a-decay of actinium 227Ac in 235U series. Known artificial isotopes: 201-222, 224-232. Found in uranium minerals. Terrestial abundance ~2 ´ 1018 ppm. Also obtainable by proton bombardment of thorium. First obtained in 1939 from an actinium prepn by Perey, J. Phys. Radium 10, 439 (1939); J. Chim. Phys. 43, 155, 262 (1946); Hyde, Ghiorso, Phys. Rev. 90, 267 (1953); Hyde, J. Am. Chem. Soc. 74, 4181 (1952). Isoln by paper chromatography: Perey, Adloff, Compt. Rend. 236, 1163 (1953). Reviews: Hyde, J. Chem. Educ. 36, 15-21 (1959); Whaley, "Sodium, Potassium, Rubidium, Cesium and Francium" in Comprehensive Inorganic Chemistry vol. 1, J. C. Bailar Jr., et al., Eds. (Pergamon Press, Oxford, 1973) pp 369-529; Chemistry of the Elements N. N. Greenwood, A. Earnshaw, Eds. (Pergamon Press, New York, 1984) pp 75-116.

Methyl Dihydrojasmonate CAS Registry Number: 24851-98-7 二氢茉莉酮酸甲酯(反式和顺式混合物)

CAS Name: 3-Oxo-2-pentylcyclopentaneacetic acid methyl ester
Additional Names: methyl 2-pentyl-3-oxocyclopentyl-1-acetate
Trademarks: Hedione (Firmenich)
Percent Composition: C 68.99%, H ...
Literature References: Fragrance compound identified as a natural product in flowers, tea, herbs, fruits and vegetables. Synthetic commercial formulations contain a racemic, near equilibrium mixture of ~10% (±)-cis and ~90% (±)-trans forms. The (+)-(1R,2S)-form is the most organoleptically active enantiomer. Prepn: E. Demole et al., Helv. Chim. Acta 45, 675, 685, 692 (1962). Fragrance monograph: Food Chem. Toxicol. 30, Suppl. 1, 85S (1992). Enantioselective synthesis of (+)- and (-)-trans forms: T. Perrard et al., Org. Lett. 2, 2959 (2000). Review of sensory properties of stereoisomers and enantioselective distribution in plant sources: P. Werkhoff et al., Food Rev. Int. 18, 103-122 (2002).

a -Bisabolol CAS Registry Number: 515-69-5 红没药醇

CAS Name: (aR,1R)-rel-a,4-Dimethyl-a-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol
Additional Names: 6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol; 1-methyl-4-(1,5-dimethyl-1-hydroxyhe...
Literature References: Fragrant sesquiterpene isolated from the essential oils of a variety of plants, shrubs and trees. Both isomers occur in nature; the (-)-form is the most widespread and is an active anti-inflammatory component of chamomile. The (+) and (-)-epi isomers are also naturally occurring. Isoln of (-)-form from Matricaria chamomilla: F. Sorm et al., Collect. Czech. Chem. Commun. 16, 626 (1951); of (+)-form from Populus balsamifera: idem et al., Chem. Listy 46, 364 (1952). Synthesis of racemic mixture: L. Ruzicka, M. Liguori, Helv. Chim. Acta 15, 3 (1932); C. D. Gutsche et al., Tetrahedron 24, 859 (1968). Enantioselective synthesis of (-)-form: H. Nemoto et al., Tetrahedron Lett. 34, 4939 (1993). Separation of four stereoisomers: K. Günther et al., Fresenius J. Anal. Chem. 345, 787 (1993). Pharmacology and toxicology of (-)-form: V. Jakovlev, A. von Schlichtegroll, Arzneim.-Forsch. 19, 615 (1969); S. Habersang et al., Planta Med. 37, 115 (1979). Comparative pharmacology of racemate and enantiomers: V. Jakovlev et al., ibid. 35, 125 (1979). Determn by HPLC in chamomile extracts: R. Herrmann, Dtsch. Apoth. Ztg. 36, 1797 (1982); by GC in cosmetic products: D. Andre et al., Int. J. Cosmet. Sci. 13, 137 (1991). Evaluation of use as dermal penetration enhancer: R. Kadir, B. W. Barry, Int. J. Pharm. 70, 87 (1991). Review of anti-inflammatory activity and use in cosmetics: N. Jellinek, Parfums Cosmet. Aromes 57, 55-57 (1984); of absolute configuration studies: G. W. O'Donnell, M. D. Sutherland, Aust. J. Chem. 42, 2021-2034 (1989).