其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Alstonine CAS Registry Number: 642-18-2 鸭脚木碱,鸡骨常山碱

CAS Name: 3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19a-methyl-20a-oxayohimbanium
Percent Composition: C 72.40%, H 5.79%, N 8.04%, O 13.78%
Literature References: From Alstonia constricta F. Mull., Rauwolfia vomitoria Afzel., Rauwolfia obscura K. Schum., Vinca rosea L., and other Apocynaceae: Sharp, J. Chem. Soc. 1934, 287; Schlittler et al., Helv. Chim. Acta 35, 271 (1952); Pillay, Kumari, J. Sci. Ind. Res. 20B, 458 (1961); C.A. 56, 7425b (1962). Structure: Bader, Helv. Chim. Acta 36, 215 (1953). Stereoisomer of serpentine (alkaloid), q.v. Stereochemistry: Wenkert, Roychaudhuri, J. Am. Chem. Soc. 79, 1519 (1957); 80, 1613 (1958); Shamma, Richey, ibid. 85, 2507 (1963). Biosynthesis: Woodward, Angew. Chem. 68, 13 (1956).

Muscazone CAS Registry Number: 2255-39-2 2-氨基-2-(2-氧代-3H-1,3-恶唑-5-基)乙酸

CAS Name: a-Amino-2,3-dihydro-2-oxo-5-oxazoleacetic acid
Additional Names: a-amino-2-oxo-4-oxazoline-5-acetic acid
Percent Composition: C 37.98%, H 3.82%, N 17.72%, O 40.48%
Literature References: From Amanita muscaria (L.) Fr., Agaricaceae: Eugster et al., Tetrahedron Lett. 1965, 1813. Structure: Fritz et al., ibid. 1965, 2075; Reiner, Eugster, Helv. Chim. Acta 50, 128 (1967). Synthesis: Göth et al., ibid. 137.

Androstane CAS Registry Number: 438-22-2 (5R,8S,9S,10S,13S,14S)-10,13-二甲基十六氢-1H-环戊[a]菲

CAS Name: (5a)-Androstane
Additional Names: etioallocholane
Percent Composition: C 87.62%, H 12.38%
Literature References: From androstane-3,17-dione: Butenandt, Tscherning, Z. Physiol. Chem. 229, 185 (1934). From androstane-3,17-diol: Steiger, Reichstein, Helv. Chim. Acta 20, 817 (1937). From D16-androstene: Prelog et al., ibid. 27, 66 (1944).

Hexestrol CAS Registry Number: 84-16-2 己烷雌酚

CAS Name: 4,4'-(1,2-Diethyl-1,2-ethanediyl)bisphenol
Additional Names: 4,4'-(1,2-diethylethylene)diphenol; meso-3,4-bis(p-hydroxyphenyl)-n-hexane; 4,4'-dihydroxy-g,d-diphenylhexane; 4,4'-dihydr...
Literature References: From anethole HBr: Campbell et al., Proc. Roy. Soc. B128, 253 (1940); Bernstein, Wallis, J. Am. Chem. Soc. 62, 2871 (1940); US 2357985 (1944); Buu-Hoi, Hoán, J. Org. Chem. 14, 1023 (1949). By the reduction of Grignard compds with cobaltous chloride: Kharasch et al., J. Am. Chem. Soc. 65, 491 (1943). Proof of meso configuration: Wessely, Welleba, Ber. 74, 777 (1941). Comprehensive description: H. Y. Aboul-Enein et al., Anal. Profiles Drug Subs. 11, 347-374 (1982).

Cuspareine CAS Registry Number: 442-33-1

CAS Name: 2-[2-(3,4-Dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydro-1-methylquinoline
Percent Composition: C 77.14%, H 8.09%, N 4.50%, O 10.28%
Literature References: From Angostura bark (Cusparia trifoliata (Willd.) Engl., Rutaceae): Tröger, Runne, Arch. Pharm. 249, 174 (1911); Späth, Pikl, Monatsh. Chem. 55, 352 (1930). Structure: Schläger, Leeb, ibid. 81, 714 (1950). Synthesis: Stanek, ibid. 88, 250 (1957).

Cusparine CAS Registry Number: 529-92-0 西花椒碱

CAS Name: 2-[2-(1,3-Benzodioxol-5-yl)ethyl]-4-methoxyquinoline
Percent Composition: C 74.25%, H 5.58%, N 4.56%, O 15.62%
Literature References: From Angostura bark: Tröger, Runne, Arch. Pharm. 249, 174 (1911); Späth, Pikl, Monatsh. Chem. 55, 352 (1930). Synthesis from 2-methyl-4-methoxyquinoline and piperonal: Späth, Brunner, Ber. 57, 1243 (1924).

Belladonnine CAS Registry Number: 510-25-8

CAS Name: 1,2,3,4-Tetrahydro-1-phenyl-1,4-naphthalenedicarboxylic acid bis(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) ester
Additional Names: isatropylditropeine; tropyl isatropate; ditropyl isatrop...
Literature References: From Atropa belladonna L. and allied Solanaceae. Probably formed during the process of extraction. Upon hydrolysis the substance extracted from plants yields b-isatropic acid and tropine: Küssner, Arch. Pharm. 276, 617 (1938); Hotovy et al., US 2734062 (1956 to E. Merck).

Retamine CAS Registry Number: 2122-29-4

CAS Name: Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocin-1-ol
Percent Composition: C 71.95%, H 10.47%, N 11.19%, O 6.39%
Literature References: From bark and young branches of Genista sphaerocarpa Lam. (Retama sphaerocarpa (Lam.) Boiss.), Leguminosae. Isoln: Battandier, Malosse, Compt. Rend. 125, 360, 450 (1897); Ribas et al., An. Fis. Quim. 42, 516 (1946), C.A. 41, 4894c (1947). Structure: Bohlmann et al., Ber. 98, 659 (1965). Synthesis: Bohlmann et al., ibid. 653. Stereochemistry: Ribas et al., Tetrahedron Lett. 1965, 3181.

Quebrachamine CAS Registry Number: 4850-21-9

CAS Name: 7-Ethyl-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole
Additional Names: kamassin
Percent Composition: C 80.80%, H 9.28%, N 9.92%
Literature References: From bark of Aspidosperma quebracho blanco Schlecht., Apocynaceae: Hesse, Ann. 211, 249 (1882); Field, J. Chem. Soc. 125, 1444 (1924). Identity with kamassin: Gellert, Witkop, Helv. Chim. Acta 35, 114 (1952). Structure: Witkop, J. Am. Chem. Soc. 79, 3193 (1957); Kny, Witkop, J. Org. Chem. 25, 635 (1960); Biemann, Spiteller, J. Am. Chem. Soc. 84, 4578 (1962). Crystal structure: C. Puglisi et al., Acta Crystallogr. B32, 1900 (1976). Total synthesis of dl-form: Stork, Dolfini, J. Am. Chem. Soc. 85, 2872 (1963); Ziegler et al., ibid. 91, 2342 (1969); Kutney et al., ibid. 92, 1727 (1970); V. S. Giri et al., J. Heterocycl. Chem. 17, 1133 (1980); S. Takano et al., Heterocycles 16, 247 (1981). Enantioselective synthesis: eidem, Chem. Commun. 1980, 616; 1981, 1153.

Morindin CAS Registry Number: 60450-21-7 桑酮-6-O-beta-D-茜黄樱草糖甙

CAS Name: 1,5-Dihydroxy-2-methyl-6-[(6-O-b-D-xylopyranosyl-b-D-glucopyranosyl)oxy]-9,10-anthracenedione
Additional Names: 2-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-1,5-dihydr...
Literature References: From bark of Coprosma australis Forst. (C. grandifolia Hook.), Rubiaceae: Briggs, Dacre, J. Chem. Soc. 1948, 564. Structure: Briggs, Le Quesne, ibid. 1963, 3471. On acid hydrolysis yields the aglucone morindone. Synthesis and structure proof: B. Vermes et al., Phytochemistry 19, 119 (1980).