其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Laureline CAS Registry Number: 81-38-9 (7aR)-11-甲氧基-7-甲基-6,7,7a,8-四氢-5H-[1,3]苯并二氧戊环并[6,5,4-De]苯并[g]喹啉

CAS Name: (7aR)-6,7,7a,8-Tetrahydro-11-methoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline
Additional Names: 10-methoxy-1,2-(methylenedioxy)aporphine
Percent Composition: C 73.7...
Literature References: From bark of Laurelia novae-zelandiae A. Cunn., Lauraceae: Aston, J. Chem. Soc. 97, 1381 (1910). Synthesis: Schlittler, Helv. Chim. Acta 15, 394 (1932); Faltis et al., Ber. 77B, 686 (1945); Gibson et al., J. Chem. Soc. C 1970, 2234; Govindachari et al., Indian J. Chem. 8, 475 (1970).

Lunacrine CAS Registry Number: 82-40-6 [2R,(-)]-3,9-二氢-8-甲氧基-9-甲基-2-异丙基呋喃并[2,3-b]喹啉-4(2H)-酮

CAS Name: (2R)-3,9-Dihydro-8-methoxy-9-methyl-2-(1-methylethyl)furo[2,3-b]quinolin-4(2H)-one
Percent Composition: C 70.31%, H 7.01%, N 5.12%, O 17.56%
Literature References: From bark of Lunasia costulata Miq., and L. amara Blanco, Rutaceae. Isoln: Boorsma, Bull. Inst. Bot. Buitenzorg 6, 15 (1900). Structure: Goodwin, Horning, J. Am. Chem. Soc. 81, 1908 (1959). Synthesis: Clarke, Grundon, J. Chem. Soc. 1964, 438. Stereochemistry: Bowman et al., J. Chem. Soc. Perkin Trans. 1 1973, 1051.

Lunacridine CAS Registry Number: 83-58-9 3-[(2R)-2-羟基-3-甲基-丁基]-4,8-二甲氧基-1-甲基-喹啉-2-酮

CAS Name: 3-[(2R)-2-Hydroxy-3-methylbutyl]-4,8-dimethoxy-1-methyl-2(1H)-quinolinone
Percent Composition: C 66.86%, H 7.59%, N 4.59%, O 20.96%
Literature References: From bark of Lunasia costulata Miq., and L. quercifolia K. Schum. et Lauterb., Rutaceae. (+)-Form is naturally occurring. Isoln: Boorsma, Bull. Inst. Bot. Buitenzorg 21, 8 (1904). Structure: Goodwin, Horning, J. Am. Chem. Soc. 81, 1908 (1959). Synthesis: Clarke, Grundon, J. Chem. Soc. 1964, 438. Synthesis and stereochemistry: R. M. Bowman et al., J. Chem. Soc. Perkin Trans. 1 1973, 1051. Short synthesis of racemate: M. Ramesh, P. Shanmugam, Indian J. Chem. 24B, 767 (1985).

Lunasine CAS Registry Number: 6901-22-0 (2R)-2-异丙基-4,8-二甲氧基-9-甲基-2,3-二氢呋喃并[2,3-b]喹啉-9-鎓

CAS Name: (2R)-2,3-Dihydro-4,8-dimethoxy-9-methyl-2-(1-methylethyl)furo[2,3-b]quinolinium
Literature References: From bark of Lunasia costulata Miq., and L. quercifolia K. Schum. et Lauterb., Rutaceae. Isoln: Boorsma, Bull. Inst. Bot. Buitenzorg 6, 14 (1900). Structure: Price, Aust. J. Chem. 12, 458 (1959). Stereochemistry: Bowman et al., J. Chem. Soc. Perkin Trans. 1 1973, 1051.

Harman CAS Registry Number: 486-84-0 哈尔满碱

CAS Name: 1-Methyl-9H-pyrido[3,4-b]indole
Additional Names: 3-methyl-4-carboline; 2-methyl-b-carboline; aribine; loturine; passiflorin
Percent Composition: C 79.10%, H 5.53%, N 15.37%
Literature References: From bark of Sickingia rubra (Mart.) K. Schum. (Arariba rubra Mart.), Rubiaceae; Symplocus racemosa Roxb., Symplocaceae; and Passiflora incarnata L., Passifloraceae: Rieth, Wohler, Ann. 120, 247 (1861); Späth, Monatsh. Chem. 40, 351; 41, 401 (1920); Neu, Arzneim.-Forsch. 4, 601 (1954). Structure: Neu, ibid. 6, 94 (1956). Synthesis: Harvey, Robson, J. Chem. Soc. 1938, 97; Snyder et al., J. Am. Chem. Soc. 70, 222 (1948); Clemo, Holt, J. Chem. Soc. 1953, 1313; Kametani et al., ibid. (C) 1968, 1006. Isoln from cigarette smoke: Poindexter, Carpenter, Chem. Ind. (London) 1962, 176. Toxicity study: E. B. Sigg et al., Arch. Int. Pharmacodyn. 149, 164 (1964).

Fraxin CAS Registry Number: 524-30-1 秦皮苷; 白蜡树苷

CAS Name: 8-(b-D-Glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one
Additional Names: 7,8-dihydroxy-6-methoxycoumarin-8-b-D-glucoside; 8-(glucosyloxy)-6-methoxyumbelliferone; fraxetin...
Literature References: From bark of the common European ash (Fraxinus excelsior L.): Salm-Horstmar, Pogg. Ann. 100, 607 (1857); from F. oxyphylla Mar., Oleaceae: Paris, Stambouli, Compt. Rend. 253, 313 (1961). Identity with paviin: Stokes, J. Chem. Soc. 12, 126 (1859). From the horse chestnut tree (Aesculus hippocastanum L., Hippocastanaceae): Reppel, Planta Med. 4, 199 (1956); from Diervilla spp., Caprifoliaceae: Charaux, J. Pharm. Chim. [7] 4, 248 (1911). Structure: Wessely, Demmer, Ber. 62, 120 (1929).

Tiliacorine CAS Registry Number: 27073-72-9

CAS Name: (1a,1'a)-6',7-Didemethoxy-6',7-epoxyrodiasine
Percent Composition: C 74.98%, H 6.29%, N 4.86%, O 13.87%
Literature References: From bark of Tiliarcora acuminata Miers, and T. racemosa Colebr., Menispermaceae. Isoln: Van Itallie, Steenhauer, Pharm. Weekbl. 59, 1381 (1922). Structure: Anjaneyulu et al., Chem. Ind. (London) 1959, 1119; Rao, Row, J. Org. Chem. 25, 981 (1960). Revised structure: Anjaneyula et al., J. Sci. Ind. Res. 21B, 602 (1962); eidem, Tetrahedron 25, 3091 (1969); M. Shamma, J. E. Foy, J. Org. Chem. 41, 1293 (1976). Abs config and biosynthesis: D. S. Bhakuni et al., Chem. Commun. 1978, 226.

Guvacine CAS Registry Number: 498-96-4 去甲槟榔次碱

CAS Name: 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid
Additional Names: 1,2,5,6-tetrahydronicotinic acid
Percent Composition: C 56.68%, H 7.14%, N 11.02%, O 25.17%
Literature References: From betel nuts, the seeds of Areca catechu L., Palmae. Extraction: Jahns, Ber. 24, 2615 (1891). Synthesis: Freudenberg, ibid. 51, 976, 1669 (1918); Hess, Leibbrandt, ibid. 51, 806; 52, 206 (1919).

Convallatoxin CAS Registry Number: 508-75-8 K-毒毛旋花子配质-3-L-鼠李糖甙

CAS Name: (3b,5b)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
Additional Names: strophanthidin a-L-rhamnoside
Trademarks: Convallaton; Corglykon; Korglykon Literature References: From blossoms of lily of the valley (Convallaria majalis L., Liliaceae): Karrer, Helv. Chim. Acta 12, 506 (1929); from Ornithogalum umbellatum L., Liliaceae: Mrozik et al., ibid. 42, 683 (1959); from Antiaris toxicaria Lesch, Moraceae: Juslen et al., ibid. 46, 117 (1963). Structure: Tschesche, Haupt, Ber. 69, 459 (1936); Fieser, Jacobsen, J. Am. Chem. Soc. 59, 2335 (1937). Cleavage into L-rhamnose and strophanthidin: Reichstein, Katz, Pharm. Acta Helv. 18, 521 (1943); see also C.A. 38, 2046. Synthesis from strophanthidin and acetobromrhamnose: Reyle et al., Helv. Chim. Acta 33, 1541 (1950); Haede et al., DE 1933090 (1971 to Hoechst). Toxicity study: W. Förster et al., Arch. Int. Pharmacodyn. 155, 165 (1965).

Cinnamyl Cinnamate CAS Registry Number: 122-69-0 桂酸桂酯

CAS Name: 3-Phenyl-2-propenoic acid 3-phenyl-2-propenyl ester
Additional Names: cinnamic acid cinnamyl ester; cinnyl cinnamate; styracin
Percent Composition: C 81.79%, H 6.10%, O 12.11%
Literature References: From buds of Populus balsamifer L., Salicaceae: Goris, Canal, Bull. Soc. Chim. Fr. 3, 1982 (1936); from Lavanga scandens Buch.-Ham., Lavangalata: Baslas, Deshapande, J. Indian Chem. Soc. 27, 379 (1950). Synthesis of trans-cinnamyl trans-cinnamate: Klemm et al., Tetrahedron 20, 871 (1964).