其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Homoeriodictyol CAS Registry Number: 446-71-9 高圣草酚

CAS Name: 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 4',5,7-trihydroxy-3'-methoxyflavanone; eriodictyonone; cyanidanon-3-methyl ether 1625 Literature References: From Eriodictyon californicum (H. A.) Torr., and E. angustifolium Nutt., Hydrophyllaceae: Geissman, J. Am. Chem. Soc. 62, 3258 (1940); Hadley, Gisvold, J. Am. Pharm. Assoc. 33, 275 (1944). Purification: Seka, Prosche, Monatsh. Chem. 69, 284 (1936). Structure: Shinoda, Sato, J. Pharm. Soc. Jpn. 49, 64 (1929), C.A. 23, 4210 (1929). Synthesis: Farooq et al., Naturwissenschaften 46, 76 (1959).

Evodiamine CAS Registry Number: 518-17-2 吴茱萸碱

CAS Name: 8,13,13b,14-Tetrahydro-14-methylindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Percent Composition: C 75.23%, H 5.65%, N 13.85%, O 5.27%
Literature References: From Evodia rutaecarpa Hook. Thoms and bark of Zanthoxylum rhetsa DC., Rutaceae: Y. Asahina, K. Kashiwaki, J. Pharm. Soc. Jpn. 1915, 1293, C.A. 10, 607 (1916); Gopinath et al., Tetrahedron 8, 293 (1960). Structure: Y. Asahina J. Pharm. Soc. Jpn. 1924, 1; Ohta, J. Pharm. Soc. Jpn. 65, 15 (1945), C.A. 45, 5697 (1951). Synthesis: Asahina, Ohta, Ber. 61B, 319 (1928); T. Kametani et al., J. Am. Chem. Soc. 98, 6186 (1976); eidem, Heterocycles 4, 23 (1976). Biosynthesis: M. Yamazaki et al., Tetrahedron Lett. 1966, 3221; 1967, 3317. Mass spec.: J. Tamas et al., Acta Chim. Acad. Sci. Hung. 89, 85 (1976).

Pyrethrosin CAS Registry Number: 28272-18-6

CAS Name: (1aR,4E,6R,6aR,9aS,10aR)-6-(Acetyloxy)-1a,3,6,6a,7,9a,10,10a-octahydro-4,10a-dimethyl-7-methyleneoxireno[8,9]cyclodeca[1,2-b]furan-8(2H)-one
Additional Names: 1,10-epoxy-6,8-dihydroxy...
Literature References: From flowers of Chrysanthemum cinerariaefolium Vis., Compositae. Isoln: Thoms, Pharm. Ztg. 1891, 503. Structure: Barton, de Mayo, J. Chem. Soc. 1957, 150; Barton et al., ibid. 1960, 2263. Revised structure: S. Iriuchijima, S. Tamura, Agric. Biol. Chem. 34, 204 (1970); E. J. Gabe et al., Chem. Commun. 1971, 559.

Quercetagetin CAS Registry Number: 90-18-6 槲皮万寿菊素

CAS Name: 2-(3,4-Dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-1-benzopyran-4-one
Additional Names: 3,3',4',5,6,7-hexahydroxyflavone; 6-hydroxycyanidenolon 1555
Percent Composition: C 56.61%, H 3...
Literature References: From flowers of French marigold, Tagetes patula Linn., Compositae: Perkin, J. Chem. Soc. 103, 209 (1913). Synthesis: Baker et al., ibid. 1929, 74; Rao, Seshadri, Proc. Indian Acad. Sci. 23A, 23 (1946), C.A. 40, 50522 (1946).

Isoquercitrin CAS Registry Number: 21637-25-2 异槲皮苷

CAS Name: 2-(3,4-Dihydroxyphenyl)-3-(b-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
Additional Names: 3,3',4',5,7-pentahydroxyflavone-3-glucoside; quercetin-3-glucoside; isotrifolii...
Literature References: From flowers of Gossypium herbaceum L., Malvaceae: Perkin, J. Chem. Soc. 95, 2181 (1909); from flowers of Aesculus hippocastanum L., Hippocastanaceae: Hörhammer, Wagner, Arch. Pharm. 290, 224 (1957); from Tropaeolum majus L., Tropaeolaceae: Delaveau, Compt. Rend. 252, 1510 (1961); from Arnica montana L., Compositae: Friedrick, Naturwissenschaften 49, 541 (1962). Structure: Attree, Perkin, J. Chem. Soc. 1927, 234. Identity with trifoliin and isotrifoliin: Hattori et al., J. Chem. Soc. Jpn. 58, 844 (1937), C.A. 32, 219c (1938). Synthesis: Ice, Wender, J. Am. Chem. Soc. 74, 4606 (1952); eidem, US 2727890 (1955 to the USAEC).

Embelin CAS Registry Number: 550-24-3 恩贝灵; 恩贝酸

CAS Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione
Additional Names: 2,5-dihydroxy-3-undecyl-p-benzoquinone; Embelic acid
Percent Composition: C 69.36%, H 8.90%, O 21.74%
Literature References: From fruit of Embelia ribes Burm., Myrsinaceae. Isoln: Heffter, Feuerstein, Arch. Pharm. 238, 15 (1900). Structure and synthesis: Fieser, Chamberlin, J. Am. Chem. Soc. 70, 71 (1948).

Rutecarpine CAS Registry Number: 84-26-4 吴茱萸次碱

CAS Name: 8,13-Dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Additional Names: rutaecarpine
Percent Composition: C 75.24%, H 4.56%, N 14.62%, O 5.57%
Literature References: From fruit of Evodia rutaecarpa Hook. Thoms. and Hortia arborea Engl., Rutaceae: Asahina, Kashiwaki, J. Pharm. Soc. Jpn. 1915, 1293; Pachter et al., J. Am. Chem. Soc. 82, 5187 (1960). Structure: Y. Asahina, J. Pharm. Soc. Jpn. 1924, 1. Synthesis: Y. Asahina et al., J. Chem. Soc. 1927, 1708; T. Kametani et al., J. Am. Chem. Soc. 99, 2306 (1977); eidem, Chem. Pharm. Bull. 26, 1922 (1978); H. Möhrle et al., Arch. Pharm. 313, 990 (1980); J. Bergman, S. Bergman, Heterocycles 16, 347 (1981). Simple synthesis: J. Kökösi et al., Tetrahedron Lett. 22, 4861 (1981). Synthesis under physiological conditions: Schöpf, Angew. Chem. 50, 779, 797 (1937). Biosynthesis: M. Yamazaki et al., Tetrahedron Lett. 1966, 3221; 1967, 3317. Mass spec.: J. Tamas et al., Acta Chim. Acad. Sci. Hung. 89, 85 (1976).

Citrullol CAS Registry Number: 1390-93-8

Percent Composition: C 72.09%, H 10.45%, O 17.46%
Literature References: From fruit pulp of Citrullus colocynthis Schrad., Cucurbitaceae: Power, Moore, J. Chem. Soc. 97, 99 (1910); Power, Salway, ibid. 103, 399, 1022 (1913); Khadem, Rahman, Tetrahedron Lett. 1962, 1137.

Sophorabioside CAS Registry Number: 2945-88-2 槐属双苷

CAS Name: 3-[4-[[2-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one
Additional Names: genistein-4'-glucosidorhamnoside
Percent Composition: C...
Literature References: From fruits of Sophora japonica L., Leguminosae. Isoln and structure: Zemplén, Bognár, Ber. 75B, 482 (1942). The biose is not identical with rutinose.

Gentiobiose CAS Registry Number: 554-91-6 β-龙胆二糖

CAS Name: 6-O-b-D-Glucopyranosyl-D-glucose
Additional Names: 6-(b-D-glucosido)-D-glucose; amygdalose
Percent Composition: C 42.11%, H 6.48%, O 51.41%
Literature References: From gentianose by partial hydrolysis with 0.2% H2SO4 or with invertin. From D-glucose by enzymatic synthesis with emulsin: Helferich, Lette, Org. Synth. 22, 53 (1942). Prepn and structure: Haworth, Wylam, J. Chem. Soc. 123, 3120 (1923); Hudson, J. Am. Chem. Soc. 51, 1708 (1930). Structure: Hassid, Ballou in W. Pigman, The Carbohydrates (Academic Press, New York, 1957) p 492. Synthesis: Helferich, Klein, Ann. 450, 219 (1926); Reynolds, Evans, J. Am. Chem. Soc. 60, 2559 (1938). Hydrolysis with almond emulsin gives 2 mols D-glucose.