其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Cyclobuxine D CAS Registry Number: 2241-90-9 环黄杨碱 D

CAS Name: (3b,5a,16a,20S)-14-Methyl-3,20-bis(methylamino)-4-methylene-9,19-cyclopregnan-16-ol
Additional Names: cyclobuxine
Percent Composition: C 77.67%, H 10.95%, N 7.25%, O 4.14%
Literature References: From Buxus sempervirens L., Buxaceae: E. Schlittler et al., Helv. Chim. Acta 32, 2209 (1949). Probably identical with Alkaloid A: Heusler, Schlittler, ibid. 2226. Structure: Brown, Kupchan, J. Am. Chem. Soc. 84, 4590 (1962). Stereochemistry: eidem, ibid. 86, 4424 (1964).

Eseridine CAS Registry Number: 25573-43-7 依舍立定

CAS Name: (4aS-cis)-2,3,4,4a,9,9a-Hexahydro-2,4a,9-trimethyl-1,2-oxazino[6,5-b]indol-6-ol methylcarbamate ester
Additional Names: physostigmine aminoxide; eserine aminoxide; eserine oxide
Pe...
Literature References: From Calabar bean (Physostigma venenosum Balf., Leguminosae): Polonovski, Nitzberg, Bull. Soc. Chim. Fr. [5] 17, 244 (1915); 21, 191 (1917). Structure: Stedman, Barger, J. Chem. Soc. 127, 247 (1925). Revised structure: Hootele, Tetrahedron Lett. 1969, 2713. Stereochemistry: Robinson, Moorcroft, J. Chem. Soc. C 1970, 2077. Total synthesis of racemate: K. Shishido et al., Chem. Commun. 1986, 904.

Ceanothic Acid CAS Registry Number: 21302-79-4 美洲茶酸

CAS Name: (2a,3b)-3-Hydroxy-A(1),28-dinorlup-20(29)-ene-2,17-dicarboxylic acid
Additional Names: emmolic acid
Percent Composition: C 74.04%, H 9.53%, O 16.44%
Literature References: From Ceanothus americanus L., Rhamnaceae (New Jersey tea). Isoln: Julian et al., J. Am. Chem. Soc. 60, 77 (1938). Identity of ceanothic acid and emmolic acid: Mechoulam, Chem. Ind. (London) 1961, 1835. Structure: de Mayo, Starratt, Tetrahedron Lett. 1961, 259; Mechoulam, J. Org. Chem. 27, 4070 (1962). Stereochemistry: de Mayo, Starratt, Can. J. Chem. 40, 788 (1962). Revised stereochemistry: Eade et al., Aust. J. Chem. 24, 621 (1971).

Erythrocentaurin CAS Registry Number: 50276-98-7 1-氧代异苯并二氢吡喃-5-甲醛

CAS Name: 3,4-Dihydro-1-oxo-1H-2-benzopyran-5-carboxaldehyde
Additional Names: 5-formyl-3,4-dihydroisocoumarin; 5-formyl-3,4-dihydro-1H-2-benzopyran-1-one
Percent Composition: C 68.18%, H 4....
Literature References: From Centaurium umbellatum Gilib., (Erythraea centaurium Pers.), Gentianaceae or Swertia japonica (Maxim.) Makino, Gentianaceae. By hydrolysis of swertiamarin and erytaurin with emulsin. Isoln: Kariyone, Matsushima, J. Pharm. Soc. Jpn. 47, 25 (1927). Structure: Kubota, Tomita, Chem. Ind. (London) 1958, 230; Kubota et al., Tetrahedron Lett. 1961, 223. Synthesis: Wenkert et al., J. Org. Chem. 29, 2534 (1964).

Chimaphilin CAS Registry Number: 482-70-2 2,7-二甲基-1,4-萘醌

CAS Name: 2,7-Dimethyl-1,4-naphthalenedione
Additional Names: 2,7-dimethyl-1,4-naphthoquinone
Percent Composition: C 77.40%, H 5.41%, O 17.18%
Literature References: From Chimaphila carymbosa Pursh. and Pyrola incarnata (Fisch.) Fernald, Ericaceae: DiModica et al., Gazz. Chim. Ital. 83, 393 (1953); Inouye, J. Pharm. Soc. Jpn. 76, 976 (1956). Structure: DiModica, Tira, Gazz. Chim. Ital. 86, 234 (1956).

Isochondrodendrine CAS Registry Number: 477-62-3 异粒枝碱

CAS Name: O7,O7'-Didemethylcycleanine
Additional Names: isobebeerine
Percent Composition: C 72.71%, H 6.44%, N 4.71%, O 16.14%
Literature References: From Chondodendron tomentosum Ruiz and Pav., Menispermaceae: Faltis, Monatsh. Chem. 33, 873 (1912); Faltis, Neumann, ibid. 42, 311 (1921); Dutcher, J. Am. Chem. Soc. 68, 419 (1946); from the drug Radix pareirae bravae: King, J. Chem. Soc. 1940, 737. Structure: Faltis, Dietreich, Ber. 67, 231 (1934); Jeffreys, J. Chem. Soc. 1956, 4451.

Hydrocinchonine CAS Registry Number: 485-65-4 氢化辛可宁

CAS Name: (9S)-10,11-Dihydrocinchonan-9-ol
Additional Names: cinchotine; cinconifine; (+)-dihydrocinchonine; pseudocinchonine
Percent Composition: C 76.99%, H 8.16%, N 9.45%, O 5.40%
Literature References: From cinchona barks: Caventou, Willm, Compt. Rend. 69, 284 (1869). Prepn from cinchonine: Hesse, Ann. 300, 46 (1898); Pum, Monatsh. Chem. 16, 68 (1895); Arlt, ibid. 20, 426, 439 (1899); Heidelberger, Jacobs, J. Am. Chem. Soc. 41, 817 (1919). Structure: Rabe, Ber. 55, 522 (1922). Conversion of hydroquinidine to hydrocinchonine: King, J. Chem. Soc. 1946, 523. HPLC determn: C.-T. A. Chung, E. J. Staba, J. Chromatogr. 295, 276 (1984). Stereospecific synthesis from secologanin: R. T. Brown, D. Curless, Tetrahedron Lett. 27, 6005 (1986). Total synthesis: M. Ihara et al., J. Chem. Soc. Perkin Trans. 1 1988, 1277.

Cubebin CAS Registry Number: 18423-69-3 荜澄茄素

CAS Name: 3,4-Bis(1,3-benzodioxol-5-ylmethyl)tetrahydro-2-furanol
Additional Names: tetrahydro-3,4-dipiperonyl-2-furanol; 5-hydroxy-3,4-bis(3,4-methylenedioxybenzyl)tetrahydrofuran
Percent C...
Literature References: From cubeb. Isoln: Capitaine, Soubeiran, Ann. 31, 190 (1839). Structure: Haworth, Kelly, Chem. Ind. (London) 1936, 901; Haensel et al., Arch. Pharm. 300, 559 (1967). Synthesis: Batterbee et al., J. Chem. Soc. C 1969, 2470.

Fichtelite CAS Registry Number: 2221-95-6 朽松木烷

CAS Name: [1S-(1a,4aa,4bb,7b,8aa,10ab)]-Tetradecahydro-1,4a-dimethyl-7-(1-methylethyl)phenanthrene
Additional Names: 18-norabietane
Percent Composition: C 86.94%, H 13.06%
Literature References: From decayed wood of conifers: Bromeis, Ann. Pharm. 37, 304 (1841). Structure: L. Ruzicka, E. Waldmann, Helv. Chim. Acta 18, 611 (1935); Crowfoot, J. Chem. Soc. 1938, 1241. Stereochemistry: Burgstahler, Marx, Tetrahedron Lett. 1964, 3333. Synthesis from abietic acid: Jensen, Johnson, J. Org. Chem. 32, 2045 (1967); Burgstahler, Marx, ibid. 34, 1562 (1969). Synthesis of dl-form: Johnson et al., J. Am. Chem. Soc. 88, 3859 (1966); 90, 5872 (1968); D. F. Taber, S. A. Saleh, ibid. 102, 5085 (1980).

Dioscin CAS Registry Number: 19057-60-4 薯蓣皂甙;薯蓣皂苷

CAS Name: (25R)-Spirost-5-en-3b-yl O-6-deoxy-a-L-mannopyranosyl-(1®2)-O-[6-deoxy-a-L-mannopyranosyl-(1®4)]-b-D-glucopyranoside
Additional Names: diosgenin bis-a-L-rhamnopyranosyl-(1®2 and 1®4)-...
Literature References: From Dioscorea tokoro Mal., Dioscoreaceae. Isoln: Tsukamoto et al., Pharm. Bull. 4, 35 (1956); Heitz, Compt. Rend. 248, 283 (1958). Structure: Kawasaki, Yamauchi, Chem. Pharm. Bull. 10, 703 (1962).