其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

a -Yohimbine CAS Registry Number: 131-03-3 α-育亨宾

CAS Name: 17a-Hydroxy-20a-yohimban-16b-carboxylic acid methyl ester
Additional Names: corynanthidine; isoyohimbine; mesoyohimbine; rauwolscine
Percent Composition: C 71.16%, H 7.39%, N 7.90%...
Literature References: From bark of Corynanthe johimbe K. Schum., Rubiaceae: Hahn, Brandenburg, Ber. 60, 669 (1927); Wilbaut, van Gastel, Rec. Trav. Chim. 54, 88 (1935); from Rauwolfia canescens L., Apocynaceae: Mookerjee, J. Indian Chem. Soc. 18, 33 (1941), C.A. 35, 7967 (1941); Stoll et al., Helv. Chim. Acta 38, 270 (1955). Identity with corynanthidine: Janot, Goutarel, Bull. Soc. Chim. Fr. 1946, 535. Identity with isoyohimbine: Heinemann, Ber. 60, 15 (1934). Identity with rauwolscine: Chatterjee et al., Chem. Ind. (London) 1954, 491. Structure and stereochemistry: Le Hir et al., Bull. Soc. Chim. Fr. 1953, 1027; Wenkert, Liu, Experientia 11, 302 (1955); Aldrich et al., J. Am. Chem. Soc. 81, 2481 (1959); Janot et al., Bull. Soc. Chim. Fr. 1961, 637. Total synthesis: Töke et al., J. Org. Chem. 38, 2496 (1973).

allo-Yohimbine CAS Registry Number: 522-94-1 别-育亨宾碱

CAS Name: 17-Hydroxyyohimban-16-carboxylic acid methyl ester
Additional Names: alloyohimbine; dihydroyohimbine
Percent Composition: C 71.16%, H 7.39%, N 7.90%, O 13.54%
Literature References: From bark of Corynanthe johimbe K. Schum., Rubiaceae: Warnat, Ber. 59, 2388 (1926); Hahn, Brandenberg, ibid. 60, 699 (1927). Identity with dihydroyohimbine: Heinemann, ibid. 67, 15 (1934). Structure and stereochemistry: LeHir et al., Bull. Soc. Chim. Fr. 1953, 1027; Janot et al., ibid. 1961, 637. Revised structure and total synthesis: Töke et al., J. Org. Chem. 38, 2496 (1973). Total synthesis: E. Wenkert et al., J. Am. Chem. Soc. 101, 5370 (1979). Review: A. Chatterjee et al., "Rauwolfia Alkaloids" in Zechmeister, Progress in the Chemistry of Organic Natural Products vol. XIII (Springer Verlag, Vienna, 1956) pp 354-356.

Cascarillin CAS Registry Number: 10118-56-6 美鼠李皮素

CAS Name: 3-(Acetyloxy)-1-[2-(3-furanyl)-2-hydroxyethyl]decahydro-5,6-dihydroxy-2,4a,5-trimethyl-1-naphthalenecarboxaldehyde
Percent Composition: C 64.69%, H 7.90%, O 27.42%
Literature References: From bark of Croton eluteria (L.) Sw., Euphorbiaceae. Isoln: Duval, J. Pharm. 8, 91 (1845); Mylius, Ber. 6, 1051 (1873); Naylor, Littlefield, Pharm. J. 57, 95 (1896). Structure and stereochemistry: McEachan et al., J. Chem. Soc. B 1966, 633.

Daphnoline CAS Registry Number: 479-36-7

CAS Name: 6,6'-Dimethoxy-2-methyloxyacanthan-7,12'-diol
Additional Names: trilobamine
Percent Composition: C 72.39%, H 6.25%, N 4.82%, O 16.53%
Literature References: From bark of Daphnandra micrantha Benth., Monimiaceae. Isoln: Pyman, J. Chem. Soc. 105, 1679 (1914). Identity with trilobamine: Bick et al., ibid. 1949, 2767. Structure: Bick et al., ibid. 1960, 4928.

Drimenin CAS Registry Number: 2326-89-8 辛辣木素

CAS Name: [5aS-(5aa,9ab,9ba)]-5,5a,6,7,8,9,9a,9b-Octahydro-6,6,9a-trimethylnaphtho[1,2-c]furan-1(3H)-one
Percent Composition: C 76.88%, H 9.46%, O 13.66%
Literature References: From bark of Drimys winteri Forst., Magnoliaceae: Appel, Dohr, Scientia 25, 137 (1958); C.A. 54, 4663f (1960). Structure and stereochemistry: Appel et al., J. Chem. Soc. 1960, 4685. Synthesis: Wenkert, Strike, J. Am. Chem. Soc. 86, 2044 (1964); Yamagawa, et al., Synthesis 1970, 257; M. Jallali-Naini et al., Tetrahedron Lett. 22, 2995 (1981).

Garryine CAS Registry Number: 561-51-3

Percent Composition: C 76.92%, H 9.68%, N 4.08%, O 9.32%
Literature References: From bark of Garrya veatchii Kellog, Garryaceae, where it occurs together with veatchine and other alkaloids: Oneto, J. Am. Pharm. Assoc. 35, 204 (1946); Wiesner et al., Can. J. Chem. 30, 608 (1952). Structure: Wiesner et al.: J. Am. Chem. Soc. 76, 6068 (1954); Djerassi et al., ibid. 77, 4801 (1955). Stereochemistry: Solo, Pelletier, Chem. Ind. (London) 1960, 1108. Racemic syntheses and resolution: Masamune, J. Am. Chem. Soc. 86, 290 (1964); Nagata et al., ibid. 929, 89, 1499 (1967); Guthrie et al., Collect. Czech. Chem. Commun. 31, 602 (1966).

Geissoschizoline CAS Registry Number: 18397-07-4

CAS Name: Curan-17-ol
Additional Names: pereirine
Percent Composition: C 76.47%, H 8.78%, N 9.39%, O 5.36%
Literature References: From bark of Geissospermum vellosii Allem., Apocynaceae: Hesse, Ann. 202, 141 (1880); Bertho, Moog, ibid. 509, 241 (1934). Identity with pereirine: Bertho, Koll, Naturwissenschaften 48, 49 (1961). Structure: Janot et al., Compt. Rend. 250, 4383 (1960); Bertho, Koll Ber. 94, 2737 (1961). Synthesis: Hymon, Schmid, Helv. Chim. Acta 49, 2067 (1966); of dl-form: Dadson, Harley-Mason, Chem. Commun. 1969, 665; Harley-Mason, Taylor, ibid. 1970, 812.

Vellosimine CAS Registry Number: 6874-98-2 维洛斯明碱

CAS Name: Sarpagan-17-al
Additional Names: velosimine
Percent Composition: C 78.05%, H 6.89%, N 9.58%, O 5.47%
Literature References: From bark of Geissosperum vellosii Allem., Apocynaceae: Rapoport et al., J. Am. Chem. Soc. 80, 1601 (1958). Structure: Rapoport, Moore, J. Org. Chem. 27, 2981 (1962); Ohashi et al., Tetrahedron 19, 2241 (1963).

Hamamelitannin CAS Registry Number: 469-32-9 金缕梅单宁

CAS Name: 2-C-[[(3,4,5-Trihydroxybenzoyl)oxy]methyl]-D-ribofuranose 5-(3,4,5-trihydroxybenzoate)
Additional Names: 2-C-(hydroxymethyl)-D-ribofuranose 2',5-digallate
Percent Composition: C 49...
Literature References: From bark of Hamamelis virginiana L., Hamamelidaceae: Grüttner, Arch. Pharm. 236, 278 (1898); from bark of Castanea dentata (Marsh.) Borkh., Fagaceae: Mayer, Kunz, Naturwissenschaften 46, 206 (1959). Structure: Mayer et al., Ann. 688, 232 (1965). Synthesis: Ezekiel et al., Carbohydr. Res. 11, 233 (1969).

Pukateine CAS Registry Number: 81-67-4 噻吩-3-乙醇

CAS Name: (7aR)-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-12-ol
Additional Names: 1,2-(methylenedioxy)-6ab-aporphin-11-ol
Percent Composition: C 73.20%, H 5...
Literature References: From bark of Laurelia novaezelandiae A. Cunn, Lauraceae. Isoln: Aston, J. Chem. Soc. 97, 1381 (1910); Bernauer, Helv. Chim. Acta 50, 1583 (1967). Structure: Barger, Giradet, ibid. 14, 481, 504 (1931); Barger, Schlittler, ibid. 15, 381 (1932). Total synthesis: Zymalkowski, Happel, Tetrahedron Lett. 1969, 219; Ber. 102, 2959 (1969); Kametani et al., J. Chem. Soc. Perkin Trans. 1 1972, 1435.