其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Norphenazone CAS Registry Number: 89-25-8 依达拉奉

CAS Name: 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
Additional Names: 3-methyl-1-phenyl-2-pyrazolin-5-one; 1-phenyl-3-methyl-5-pyrazolone; C.I. Developer 1; developer Z; norantipyrinePerce...
Literature References: Free radical scavenger; metabolite of antipyrine, q.v. Prepn: L. Knorr, Ann. 238, 137 (1887). Structural determn by NMR and IR: R. Jones et al., Tetrahedron 19, 1497 (1963); F.-D. Höppner et al., J. Prakt. Chem. 318, 555 (1976). Crystal structure: F. Bechtel et al., Cryst. Struct. Commun. 3, 469 (1973). HPLC determn in urine: M. A. Mikati et al., J. Chromatogr. 433, 305 (1988). Anti-ischemic and radical scavenging actions: T. Watanabe et al., J. Pharmacol. Exp. Ther. 268, 1597 (1994).

b -Irone CAS Registry Number: 79-70-9 4-[2,5,6,6-四甲基-1(或2)-环己烯-1-基]-3-丁烯-2-酮

CAS Name: 4-(2,5,6,6-Tetramethyl-1-cyclohexen-1-yl)-3-buten-2-one
Percent Composition: C 81.50%, H 10.75%, O 7.75%
Literature References: Frequent byproduct in synthesis of a-irone. Stereoselective synthesis of (±)-form: S. Torii et al., J. Org. Chem. 45, 16 (1980). For general refs see a-irone.

g -Ergostenol CAS Registry Number: 516-78-9 5-alpha-麦角甾-7-烯-3-beta-醇

CAS Name: (3b,5a)-Ergost-7-en-3-ol
Percent Composition: C 83.93%, H 12.07%, O 3.99%
Literature References: From 22,23-dihydroergosterol: Laucht, Z. Physiol. Chem. 237, 236 (1935); from ergosterol: Wieland, Benend, Ann. 554, 1 (1943); Bladon et al., J. Chem. Soc. 1951, 2402.

Alizarine Orange CAS Registry Number: 568-93-4 1,2-二羟基-3-硝基蒽醌

CAS Name: 1,2-Dihydroxy-3-nitro-9,10-anthracenedione
Additional Names: 1,2-dihydroxy-3-nitroanthraquinone; 3-nitroalizarin; C.I. Mordant Orange 14; C.I. 58015
Percent Composition: C 58.96%, ...
Literature References: From 3-bromoalizarin in acetic acid with nitric acid: Barnett, Cook, J. Chem. Soc. 121, 1376 (1922). Additional prepns: Colour Index vol. 4 (3rd ed., 1971) p 4514.

Atranorin CAS Registry Number: 479-20-9 黑茶渍素

CAS Name: 3-Formyl-2,4-dihydroxy-6-methylbenzoic acid 3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl ester
Additional Names: atranoric acid
Percent Composition: C 60.96%, H 4.85%, O 34.19%
Literature References: From a number of lichens. Belongs to the group of lichen acids. Isoln: Paterno, Ogliarori, Gazz. Chim. Ital. 1877, 189; Hesse, Ber. 30, 357, 1983 (1897); St. Pfau, Helv. Chim. Acta 9, 650 (1926). Synthesis: Neelakantan et al., Tetrahedron Lett. 1962, 287. TLC analysis: R. Klee, L. Steubing, J. Chromatogr. 129, 478 (1976); J. L. Ramaut et al., ibid. 155, 450 (1978).

Jesaconitine CAS Registry Number: 16298-90-1 乌头-3,8,13,14,15-戊调,20-乙基-1,6,16-三甲氧基-4-(甲氧基甲基)-,8-乙酸酯14-(4-甲氧基苯甲酸盐),(1a,3a,6a,14a,15a,16b)-

CAS Name: (1a,3a,6a,14a,15a,16b)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-(4-methoxybenzoate)
Percent Composition: C 62.21%, H 7.31%, N 2.07%, O 28...
Literature References: From Aconitum fischeri Reich. and A. sachalinense F. Schmidt, Ranunculaceae: Makoshi, Arch. Pharm. 247, 243 (1909); Majima, Morio, Ber. 57, 1472 (1924). Structure: Ochiai et al., J. Pharm. Soc. Jpn. 75, 545 (1955); Keith, Pelletier, Chem. Commun. 1967, 993 (corr. ibid. 1968, 1739); eidem, J. Org. Chem. 33, 2497 (1968).

Songorine CAS Registry Number: 509-24-0 一枝蒿庚素; 准葛尔乌头碱

CAS Name: (1a,15b)-21-Ethyl-1,15-dihydroxy-4-methyl-16-methylene-7,20-cycloveatchan-12-one
Additional Names: napellonine; zongorine
Percent Composition: C 73.91%, H 8.74%, N 3.92%, O 13.43%
Literature References: From Aconitum songoricum Popov, Ranunculaceae: Yunusov, J. Gen. Chem. USSR 18, 515 (1948); Kuzovkov, ibid. 23, 504 (1953); 25, 2006 (1955). Identity with napellonine: Kuzovkov, Zh. Obshch. Khim. 28, 2283 (1958); 29, 1728 (1959). Structure: Sugasawa, Chem. Pharm. Bull. 9, 889, 897 (1961). Absolute configuration: Okamoto et al., ibid. 13, 1270 (1965). Synthesis of the aromatic intermediate: Wiesner et al., Can. J. Chem. 51, 3978 (1973). Pharmacology: Sadritdinov, Farmakol. Alk. No. 312 (1965), C.A. 66, 93772d (1967). Mass spectra data: Yunusov et al., Khim. Prir. Soedin. 6, 101 (1970), C.A. 73, 131178u (1970). Pharmacology and toxicity data: N. G. Bisset, J. Ethnopharmacol. 4, 247-336 (1981).

Adonitoxin CAS Registry Number: 17651-61-5 福寿草毒苷

CAS Name: (3b,5b,16b)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14,16-dihydroxy-19-oxocard-20(22)-enolide
Percent Composition: C 63.26%, H 7.69%, O 29.06%
Literature References: From Adonis vernalis L., Ranunculaceae: Katz, Reichstein, Pharm. Acta Helv. 22, 437 (1947); C.A. 43, 1790i (1949); Pitra, Cekan, Collect. Czech. Chem. Commun. 26, 1551 (1961). Structure: Poláková, Cekan, Chem. Ind. (London) 1963, 1766.

b -Ergostenol CAS Registry Number: 632-31-5 (3beta,5alpha)-麦角甾-14-烯-3-醇

CAS Name: (3b,5a)-Ergost-14-en-3-ol
Percent Composition: C 83.93%, H 12.07%, O 3.99%
Literature References: From a-ergostenol by treatment with HCl-gas in chloroform: Reindel et al., Ann. 452, 34 (1927).

Gypsogenin CAS Registry Number: 639-14-5 丝石竹皂苷元

CAS Name: (3b,4a)-3-Hydroxy-23-oxoolean-12-en-28-oic acid
Additional Names: githagenin; albasapogenin; gypsophilasapogenin
Percent Composition: C 76.55%, H 9.85%, O 13.60%
Literature References: From Agrostemma githago (L.) Scop., Caryophyllaceae: Wedekind, Krecke, Z. Physiol. Chem. 155, 122 (1925); from Gypsophila oldhamiana, Caryophyllaceae: Kutani, Karr, J. Pharm. Soc. Jpn. 64, 18 (1944), C.A. 45, 2961d (1951). Structure: Ruzicka, Giacomello, Helv. Chim. Acta 20, 299 (1937). Identity with githagenin: Kon, Soper, J. Chem. Soc. 1940, 617.