其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Enoxolone CAS Registry Number: 471-53-4 甘草次酸; beta-甘草亭酸

CAS Name: (3b,20b)-3-Hydroxy-11-oxoolean-12-en-29-oic acid
Additional Names: 3b-hydroxy-11-oxoolean-12-en-30-oic acid; glycyrrhetic acid; 18b-glycyrrhetinic acid; uralenic acid
Trademarks: A...
Literature References: From glycyrrhizic acid, q.v. Structure: Ruzicka et al., Helv. Chim. Acta 26, 2143, 2278 (1943). Stereochemistry: Beaton, Spring, J. Chem. Soc. 1955, 3126. Prepn from shredded licorice root: Mer, Am. Perfum. Aromat. 74(6), 39 (1959). Manuf: GB 833184 (1960 to Carlo Erba). Identity with uralenic acid: Belous et al., Zh. Obshch. Khim. 35, 401 (1965). Metabolism: Parke et al., J. Pharm. Pharmacol. 15, 500 (1963). Mechanism of action: Helbing, Berntsen, Pharm. Weekbl. 100, 1438 (1965).

Glucovanillin CAS Registry Number: 494-08-6 4-(beta-D-葡萄糖基)-3-甲氧基苯甲醛

CAS Name: 4-(b-D-Glucopyranosyloxy)-3-methoxybenzaldehyde
Additional Names: vanillin-D-glucoside; avenein; vanilloside
Percent Composition: C 53.50%, H 5.77%, O 40.73%
Literature References: From green fruit of vanilla: Goris, Compt. Rend. 179, 70 (1924). From coniferin by oxidation with CrO3: Tremann, Ber. 18, 1595 (1885). Structure and synthesis: Fischer, Raske, Ber. 42, 1475 (1909); Thorpe, Williams, J. Chem. Soc. 1937, 494.

Olivil CAS Registry Number: 2955-23-9 橄榄树脂素

CAS Name: [2S-(2a,3b,4a)]-Tetrahydro-4-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-furanmethanol
Percent Composition: C 63.82%, H 6.43%, O 29.75%
Literature References: From gum-resin of Olea europaea L., Oleaceae. Isoln: Pelletier, Ann. Chim. Phys. 51, 196 (1833). Structure: Traverso, Gazz. Chim. Ital. 90, 792 (1960); Smith, Tetrahedron Lett. 1963, 991. Revised structure: Ayres, Mhasalkar, ibid. 1964, 335; eidem, J. Chem. Soc. 1965, 3586.

Pododacric Acid CAS Registry Number: 32630-75-4 12,16,17-三羟基松香-8,11,13-三烯-19-酸

CAS Name: [1S-(1a,4aa,10ab)]-1,2,3,4,4a,9,10,10a-Octahydro-6-hydroxy-7-[2-hydroxy-1-(hydroxymethyl)ethyl]-1,4a-dimethyl-1-phenanthrenecarboxylic acid
Additional Names: 12-hydroxy-13-[2-hydroxy-...
Literature References: From heartwood of Podocarpus dacrydioides; P. totara: Briggs et al., Tetrahedron 7, 270 (1959); Cambie, Mander, ibid. 18, 465 (1962). Structure: Cambie, Mathai, Chem. Commun. 1971, 154.

Asperuloside CAS Registry Number: 14259-45-1 车叶草苷

CAS Name: [2aS-(2aa,4aa,5a,7ba)]-4-[(Acetyloxy)methyl]-5-(b-D-glucopyranosyloxy)-2a,4a,5,7b-tetrahydro-1H-2,6-dioxacyclopent[cd]inden-1-one
Additional Names: rubichloric acid
Percent Composi...
Literature References: From herb of Asperula odorata L., Galium aparine L., Rubiaceae. Occurs also in Coprosma spp. Isoln: Hérissey, Compt. Rend. 180, 1695 (1925); Briggs, Nicholls, J. Chem. Soc. 1954, 3940. Structure: Grimshaw, Chem. Ind. (London) 1961, 403; Briggs et al., J. Chem. Soc. 1965, 2595.

Lobelanidine CAS Registry Number: 552-72-7 (R)-2-((2R,6S)-6-((S)-2-羟基-2-苯乙基)-1-甲基哌啶-2-基)-1-苯乙醇 (洛贝林盐酸盐杂质)

CAS Name: [2a(R*),6a(S*)]-1-Methyl-a,a'-diphenyl-2,6-piperidinediethanol
Additional Names: a,a'-[(1-methyl-2,6-piperidinediyl)dimethylene]dibenzyl alcohol
Percent Composition: C 77.84%, H 8....
Literature References: From herb of Lobelia inflata L., Lobeliaceae: Wieland et al., Ann. 444, 40 (1925). Synthesis: Wieland, Drishaus, ibid. 473, 102 (1929). Comprehensive review of H. Wieland's work on Lobelia alkaloids with complete references is given by Schöpf, Naturwissenschaften 30, 359 (1942).

Monotropein CAS Registry Number: 5945-50-6 水晶兰苷

CAS Name: [1S-(1a,4aa,7b,7aa)]-1-(b-D-Glucopyranosyloxy)-1,4a,7,7a-tetrahydro-7-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-4-carboxylic acid
Percent Composition: C 49.23%, H 5.68%, O 45.09%
Literature References: From herb of Monotropa hypopitys L., Ericaceae: Bridel, Compt. Rend. 176, 1742 (1923); Bull. Soc. Chim. Biol. 5, 722 (1923). Structure: Inouye et al., Tetrahedron Lett. 1963, 1031; Bobbitt et al., Chem. Ind. (London) 1964, 931. Stereochemistry: Norio et al., Tetrahedron Lett. 1967, 2367. GC-mass spec studies: H. Inouye et al., J. Chromatogr. 118, 201 (1976). Purgative activity: eidem, Planta Med. 25, 285 (1976).

Parthenin CAS Registry Number: 508-59-8 银胶菊宁

CAS Name: [3aS-(3aa,6b,6aa,9ab,9ba)]-3,3a,4,5,6,6a,9a,9b-Octahydro-6a-hydroxy-6,9a-dimethyl-3-methyleneazuleno[4,5-b]furan-2,9-dione
Additional Names: 1,6b-dihydroxy-4-oxo-10aH-ambrosa-2,11(13)...
Literature References: From herb of Parthenium hysterophorus L., Compositae. Parthenin is the substance largely responsible for the allergic contact dermatitis caused by P. hysterophorus. Isoln: Arny, Am. J. Pharm. 69, 169 (1897). Isoln and structure: Herz et al., Tetrahedron Lett. 1961, 82; Herz et al., J. Am. Chem. Soc. 84, 2601 (1962). Abs config: Emerson et al., Tetrahedron Lett. 1966, 6151. Total synthesis of (±)-form: P. Kok et al., Bull. Soc. Chim. Belg. 87, 615 (1978); C. H. Heathcock et al., J. Am. Chem. Soc. 104, 6081 (1982).

Cetraric Acid CAS Registry Number: 489-49-6 9-乙氧基甲基-4-甲酰基-3,8-二羟基-1,6-二甲基-11-氧代二苯并[b,e][1,4]二氧杂卓-7-羧酸

CAS Name: 9-(Ethoxymethyl)-4-formyl-3,8-dihydroxy-1,6-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid
Additional Names: cetrarin
Percent Composition: C 59.70%, H 4.51%, O 35....
Literature References: From Iceland moss, Cetraria islandica (L.) Ach., Parmeliaceae. Isoln: Schnedermann, Knopp, Ann. 55, 144 (1845). Structure: Asahina, Asano, Ber. 66, 893 (1933).

D -Ribose-5-phosphoric Acid CAS Registry Number: 4300-28-1 (2,3,4-三羟基-5-氧代戊基)磷酸二氢酯

CAS Name: 5-(Dihydrogen phosphate)-D-ribose
Additional Names: D-ribofuranose-5-phosphoric acid; D-ribose-5-phosphate
Percent Composition: C 26.10%, H 4.82%, O 55.62%, P 13.46%
Literature References: From inosinic acid: Levene, Jacobs, Ber. 41, 2703 (1908); 44, 746 (1911); Levene, Mori, J. Biol. Chem. 81, 215 (1929); Levene, Stiller, ibid. 104, 299 (1934); LePage, Umbreit, ibid. 148, 255 (1943); Marmur et al., Arch. Biochem. Biophys. 34, 209 (1951). Purification: Groth et al., J. Biol. Chem. 199, 389 (1952). Differentiation between ribose-5-phosphate and ribose-3-phosphate by means of the orcinol-pentose reaction: Albaum, Umbreit, ibid. 167, 369 (1947).