其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Tropacocaine CAS Registry Number: 537-26-8

CAS Name: exo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol benzoate (ester)
Additional Names: 1aH,5aH-tropan-3b-ol benzoate; benzoylpseudotropeine; benzoyl-y-tropeine; pseudotropine benzoate; y-tropi...
Literature References: From Javanese coca leaves. Prepared by heating pseudotropine with water and benzoic anhydride: Wilstätter, Ber. 29, 943 (1896). Stereochemistry: Beyerman et al., Rec. Trav. Chim. 75, 1445 (1956).

Kopsine CAS Registry Number: 559-48-8 夾竹桃鹼

CAS Name: 3-Hydroxy-22-oxokopsan-1-carboxylic acid methyl ester
Percent Composition: C 69.46%, H 6.36%, N 7.36%, O 16.82%
Literature References: From Kopsia fructicosa A.D., Apocynaceae: Bhattacharya et al., J. Am. Chem. Soc. 71, 3370 (1949). Structure: Spiteller, Monatsh. Chem. 93, 1220 (1962); Govindachari et al., Helv. Chim. Acta 45, 1146 (1962); 46, 572 (1963); Guggisberg et al., ibid. 52, 76 (1969).

a -Antiarin CAS Registry Number: 23605-05-2 3beta-[(6-脱氧-beta-D-古洛吡喃糖基)氧基]-5,12beta,14-三羟基-19-氧代-5beta-心甾-20(22)-烯内酯

CAS Name: (3b,5b,12b)-3-[(6-Deoxy-b-D-gulopyranosyl)oxy]-5,12,14-trihydroxy-19-oxocard-20(22)-enolide
Percent Composition: C 61.47%, H 7.47%, O 31.06%
Literature References: From latex (arrow poison) of the upas tree, Antiaris toxicaria Lesch., Moraceae, found in Indonesia: Taylor, Br. J. Pharmacol. 8, 237 (1953). Older literature and isoln: Doebel et al., Helv. Chim. Acta 31, 688 (1948); Dolder et al., ibid. 38, 1364 (1955). Structure of aglycone: Martin, Tamm, ibid. 42, 696 (1959). The sugar portion of a-antiarin is antiarose (D-gulomethylose), while that of the isomeric b-antiarin is L-rhamnose. Structure: Juslén et al., ibid. 45, 2285 (1962). Toxicity: Chen, Henderson, J. Pharmacol. Exp. Ther. 150, 53 (1965).

Holarrhenine CAS Registry Number: 561-22-8

CAS Name: (3b,12b)-3-(Dimethylamino)con-5-enin-12-ol
Additional Names: 12b-hydroxyconessine
Percent Composition: C 77.37%, H 10.82%, N 7.52%, O 4.29%
Literature References: From leaves and bark of Holarrhena congolensis Stapf, Apocynaceae. Isoln: Pyman, J. Chem. Soc. 115, 163 (1919). Structure: Uffer, Helv. Chim. Acta 39, 1834 (1956); van Hove, Tetrahedron 7, 104 (1959).

Scoparin CAS Registry Number: 301-16-6 金雀花苷

CAS Name: 8-b-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 8-glycosyl-4',5,7-trihydroxy-3'-methoxyflavone; scoparoside
Percent Composi...
Literature References: From leaves and branches of Spartium scoparium L., Leguminosae: Stenhouse, Ann. 78, 15 (1851); Mascré, Paris, Compt. Rend. 204, 1270 (1937). Structural study: Hörhammer et al., Naturwissenschaften 49, 393 (1962). Revised structure: Prox, Tetrahedron 24, 3697 (1968).

Securinine CAS Registry Number: 5610-40-2 一叶萩碱

CAS Name: Securinan-11-one
Percent Composition: C 71.87%, H 6.96%, N 6.45%, O 14.73%
Literature References: From leaves and roots of Securinega suffruticosa Rehder, Euphorbiaceae found in the Ussuri region: Murav'eva, Ban'kovskii, C.A. 50, 17335c (1956); eidem, Dokl. Akad. Nauk SSSR 110, 998 (1956), C.A. 51, 8121a (1957). Improved extraction process: Kogan et al., GB 116947l (1959 to All-Union Sci. Res. Inst. of Medicinal Plants), C.A. 72, 47349x (1970) corresp to US 3538103 (1970). Structure: Satoda et al., Tetrahedron Lett. 1962, 1199; Mukherjee et al., Naturwissenschaften 50, 155 (1963); Saito et al., Tetrahedron 19, 2085 (1963). Stereochemistry: Nakano et al., Chem. Ind. (London) 1963, 1034; Parello et al., Bull. Soc. Chim. Fr. 1963, 898; Nakano et al., J. Org. Chem. 28, 2619 (1963); Horii et al., Tetrahedron 19, 2101 (1963); Imado et al., Chem. Ind. (London) 1964, 1691. Synthesis of the racemate: Saito et al., Chem. Pharm. Bull. 14, 313, 1059 (1966); Horii et al., Tetrahedron 23, 1165 (1967). Toxicology study: S. L. Friess et al., Toxicol. Appl. Pharmacol. 3, 347 (1961).

Ampelopsin CAS Registry Number: 27200-12-0 蛇葡萄素; 二氢杨梅素

CAS Name: (2R-trans)-2,3-Dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 3,3',4',5,5',7-hexahydroxyflavanone; ampeloptin; dihydromyricetin
Percent...
Literature References: From leaves of Ampelopsis meliaefolia Kudo, Vitaceae: Kotake, Kubota, Ann. 544, 253 (1940); from bark of Pinus contoria Dougl., Pinaceae: Hergert, J. Org. Chem. 21, 534 (1956); US 2870165 (1959 to Rayonier); from Erythrophleum africanum (Welw.) Harms, Caesalpiniaceae: Hansel, Klaffenbach, Arch. Pharm. 294, 158 (1961). Synthesis from myricetin, q.v.: Kotake, Kubota, J. Inst. Polytech. Osaka City Univ. 1, no. 2, 47 (1950), C.A. 46, 2052e (1952).

Chimonanthine CAS Registry Number: 5545-89-1 山腊梅碱

CAS Name: 1-Demethylcalycanthidine
Percent Composition: C 76.27%, H 7.56%, N 16.17%
Literature References: From leaves of Chimonanthus fragrans Lindle, Calicanthaceae: Hodson et al., Proc. Chem. Soc. London 1961, 465. Structure: Clayton et al., Tetrahedron 18, 1495 (1962). Synthesis: Hendrickson et al., Proc. Chem. Soc. London 1962, 383; Scott et al., J. Am. Chem. Soc. 86, 302 (1964); Hall et al., Tetrahedron 23, 4131 (1967).

Meteloidine CAS Registry Number: 526-13-6 (6R,7S)-6,7-二羟基-8-甲基-8-氮杂双环[3.2.1]辛-3-yl (2E)-2-甲基丁-2-烯酸盐

CAS Name: [1a,3b(E),5a,6a,7a]-2-Methyl-2-butenoic acid 6,7-dihydroxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Additional Names: (E)-1aH,5aH-tropane-3a,6b,7b-triol 3-(2-methylcrotonate); 3-(3,...
Literature References: From leaves of Datura meteloides DC., Solanaceae: Pyman, Reynolds, J. Chem. Soc. 93, 2077 (1908); King, ibid. 115, 487 (1919); from D. ferox L.: Evans, Wellendorf, ibid. 1959, 1406. Stereochemistry: Heusner, Z. Naturforsch. 9b, 683 (1954). Synthesis: Zeile, Heusner, Arch. Pharm. 292, 238 (1959).

Lawsone CAS Registry Number: 83-72-7 2-羟基-1,4萘醌

CAS Name: 2-Hydroxy-1,4-naphthalenedione
Additional Names: 2-hydroxy-1,4-naphthoquinone
Percent Composition: C 68.97%, H 3.47%, O 27.56%
Literature References: From leaves of Lawsonia inermis L. and L. alba Lam., Lythraceae: Latif, Indian J. Agric. Sci. 29, No. 2-3, 147 (1959), C.A. 55, 14828g (1961). Synthesis: Fieser, J. Am. Chem. Soc. 70, 3165 (1948); Jain, Seshadri, Proc. Indian Acad. Sci. 35A, 233 (1952); Eistert, Müller, Ber. 92, 2071 (1959).