其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Anhalonine CAS Registry Number: 519-04-0 仙人掌种子油

CAS Name: 6,7,8,9-Tetrahydro-4-methoxy-9-methyl-1,3-dioxolo[4,5-h]isoquinoline
Percent Composition: C 65.14%, H 6.83%, N 6.33%, O 21.69%
Literature References: From mescal buttons [Lophophora williamsii (Lemaire) Coult. (Anhalonium lewinii Henn.), Cactaceae] also in Ariocarpus, in Gymnocalycium gibbosum. Synthesis of dl-form and resolution: Späth, Kesztler, Ber. 68, 1663 (1935); Brossi et al., J. Am. Chem. Soc. 93, 6248 (1971). Configuration: Battersby, Edwards, J. Chem. Soc. 1960, 1214.

Anhalonidine CAS Registry Number: 17627-77-9 无盐掌定

CAS Name: 1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methyl-8-isoquinolinol
Additional Names: 6,7-dimethoxy-8-hydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
Percent Composition: C 64.55%, H 7.67%, ...
Literature References: From mescal buttons, the buds of Lophophora williamsii (Lemaire) Coult. (Anhalonium lewinii Henn.) Cactaceae: Heffter, Ber. 27, 2975 (1894); 29, 221 (1896); Kauder, Arch. Pharm. 237, 190 (1899). Structure and synthesis from 3-acetoxy-4,5-dimethoxy-N-acetylphenethylamine: Späth, Passl, Ber. 65, 1778 (1932); from mescaline: Brossi et al., Helv. Chim. Acta 47, 2089 (1964). Biosynthesis: Kapadia et al., J. Am. Chem. Soc. 92, 6943 (1970).

Tazettine CAS Registry Number: 507-79-9 多花水仙碱

Additional Names: Sekisanine; sekisanoline; ungernine
Percent Composition: C 65.24%, H 6.39%, N 4.23%, O 24.14%
Literature References: From Narcissus tazetta L., Lycoris radiata Herb., Ungernia sewerzowi (Rgl.) Fedtsch., and other Amaryllidaceae: Späth, Kahovec, Ber. 67, 1501 (1934). Structure and stereochemistry: Ikeda et al., J. Chem. Soc. 1956, 4749. Abs config: Highet, Highet, Tetrahedron Lett. 1966, 4099. Synthesis: Hendrickson et al., J. Am. Chem. Soc. 92, 5538 (1970); Tsuda et al., Tetrahedron Lett. 1972, 3153. Biosynthesis: Fales, Wildman, J. Am. Chem. Soc. 86, 294 (1964). Identity with sekisanine and sekisanoline: Ikeda et al., loc. cit. Stereospecific total synthesis: Hendrickson et al., J. Am. Chem. Soc. 96, 7781 (1974); S. Danishefsky et al., ibid. 102, 2838 (1980); 104, 7591 (1982).

Carotol CAS Registry Number: 465-28-1 胡萝卜次醇

CAS Name: [3R-(3a,3aa,8aa)]-2,3,4,5,8,8a-Hexahydro-6,8a-dimethyl-3-(1-methylethyl)-3a(1H)-azulenol
Additional Names: 2,3,4,5,8,8a-hexahydro-3-isopropyl-6,8a-dimethyl-3a(1H)-azulenol
Percent ...
Literature References: From oil of carrot seeds, Daucus carota L., Umbelliferae: Asahina, Tsukamoto, J. Pharm. Soc. Jpn. 525, 961 (1925), C.A. 20, 2845 (1926); Sorm et al., Collect. Czech. Chem. Commun. 16, 47 (1951); Pigulevskii, Kovaleva, Zh. Prikl. Khim. 32, 2703 (1959). Structure: Sykora et al., Collect. Czech. Chem. Commun. 26, 788 (1961); Zalkow et al., J. Org. Chem. 26, 981 (1961). Stereochemistry: Levisalles, Rudler, Bull. Soc. Chim. Fr. 1964, 2020; 1967, 2059. Synthesis of (+)-form: DeBroissia et al., ibid. 1972, 4314; eidem, Chem. Commun. 1972, 855.

Daucol CAS Registry Number: 887-08-1 (1R)-1beta-异丙基-3abeta,6-二甲基-6b,8abeta-环氧十氢薁-5a-醇

CAS Name: Octahydro-6,8a-dimethyl-3-(1-methylethyl)-1H-3a,6-epoxyazulen-7-ol
Additional Names: 2,3,4,5,6,7a,8,8a-octahydro-3-isopropyl-6,8a-dimethyl-1H-3a,6-epoxyazulen-7-ol
Percent Composit...
Literature References: From oil of carrot seeds, Daucus carota L., Umbelliferae: Richter, Arch. Pharm. 247, 391 (1909). Structure: Sykora et al., Collect. Czech. Chem. Commun. 26, 788 (1961); Zalkow et al., J. Org. Chem. 26, 981 (1961). Stereochemistry: Levisalles, Rudler, Bull. Soc. Chim. Fr. 1964, 2020; 1967, 2059. Synthesis of (-)-form: DeBroissia et al., Chem. Commun. 1972, 855; eidem, Bull. Soc. Chim. Fr. 1972, 4314.

Protopine CAS Registry Number: 130-86-9 原阿片碱

CAS Name: 4,6,7,14-Tetrahydro-5-methyl-bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one
Additional Names: 7-methyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one; fumarine; macleyine...
Literature References: From opium: Hesse, Ber. 4, 693 (1871); also from the herb Fumaria officinalis L., Chelidonium majus L., and many other Papaveraceae and Fumariaceae: Manske in The Alkaloids vol. IV, R. H. F. Manske, H. L. Holmes, Eds. (Academic Press, New York, 1954) pp 157-159. Structure: Perkin, Jr., J. Chem. Soc. 109, 815 (1916); Gadamer, Bruchhausen, Arch. Pharm. 260, 97 (1922); Mottus et al., Can. J. Chem. 31, 1144 (1953); Anet, Marion, ibid. 32, 452 (1954). Synthesis: Haworth, Perkin, J. Chem. Soc. 1926, 1769. Crystal structure: Hall, Ahmed, Acta Crystallogr. 24B, 337 (1968).

Aporeine CAS Registry Number: 2030-53-7 阿朴雷因

CAS Name: (7aS)-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline
Additional Names: aporheine; 1,2-methylenedioxyaporphine; (+)-roemerine
Percent Composition: C 77...
Literature References: From Papaver dubium L., Papaveraceae: Pavesi, Gazz. Chim. Ital. 37 I, 629 (1907); 44 I, 398 (1914). Structure and identity with (+)-roemerine: Slavik, Collect. Czech. Chem. Commun. 28, 1738 (1963). Synthesis of dl-roemerine: Marion, Grassie, J. Am. Chem. Soc. 66, 1290 (1944).

Leucocyanidin CAS Registry Number: 480-17-1 无色矢车菊素

CAS Name: 2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,4,5,7-tetrol
Additional Names: 3,3',4,4',5,7-flavanhexol; 3,3',4,4',5,7-hexahydroxyflavane; leucocyanidol
Trademarks: Flavan (...
Literature References: From petals of Asiatic cotton flowers (Gossypium spp): Stephens, Arch. Biochem. Biophys. 18, 449 (1948); from Butea frondosa Koen. ex Roxb., Leguminosae: Ganguly, Seshadri, Tetrahedron 6, 21 (1959). Prepn from quercetin: Bauer et al., Chem. Ind. (London) 1954, 433; from taxifolin: Freudenberg, Weinges, Ann. 613, 61 (1958). Metabolism: Claveau, Masquelier, Can. J. Pharm. Sci. 1, 74 (1966). See also Bioflavonoids.

Athamantin CAS Registry Number: 1892-56-4 阿塔曼素

CAS Name: (8S-cis)-3-Methylbutanoic acid 8,9-dihydro-8-[1-methyl-1-(3-methyl-1-oxobutoxy)ethyl]-2-oxo-2H-furo[2,3-h]-1-benzopyran-9-yl ester
Additional Names: isovaleric acid diester with 8,9-d...
Literature References: From Peucedanum oreoselinum (L.) Moench (Athamanta oreoselinum L.), Ammi visnaga Lam., Umbelliferae. Isoln: Schnedermann, Winckler, Ann. 51, 315 (1844). Structure: Halpern et al., Helv. Chim. Acta 40, 758 (1957). Absolute configuration: Nakazaki et al., Tetrahedron Lett. 1966, 4735.

Pilocereine CAS Registry Number: 2552-47-8 6-甲氧基-8-[[6-甲氧基-8-[[6-甲氧基-2-甲基-1-(2-甲基丙基)-3,4-二氢-1H-异喹啉-7-基]氧基]-2-甲基-1-(2-甲基丙基)-3,4-二氢-1H-异喹啉-7-基]氧基]-2-甲基-1-(2-甲基丙基)-3,4-二氢-1H-异喹啉-7-醇

Percent Composition: C 72.64%, H 8.81%, N 5.65%, O 12.90%
Literature References: From Pilocereus sargentianus Orcutt, Lophocereus schottii Britt. and Rose, Cactaceae. Isoln: Heyl, Arch. Pharm. 239, 451 (1901); Djerassi et al., J. Am. Chem. Soc. 75, 3632 (1953). Structure: eidem, ibid. 84, 3210 (1962). Biosynthesis: Schütte, Seelig, Ann. 730, 186 (1969); O'Donovan et al., J. Chem. Soc. C 1971, 2398.