其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Sophorose CAS Registry Number: 534-46-3 Α-2-葡糖-Β-葡糖苷

CAS Name: 2-O-b-D-Glucopyranosyl-a-D-glucose
Percent Composition: C 42.11%, H 6.48%, O 51.41%
Literature References: From pods of Sophora japonica L., Leguminosae: Rebaté, Bull. Soc. Chim. Fr. 7, 565 (1940); Clancy, J. Chem. Soc. 1960, 4213; Clancy in Methods in Carbohydrate Chemistry vol. I, R. L. Whistler, M. L. Wolfrom, Eds. (Academic Press, New York, 1962) pp 345-349. Structure and synthesis: Coxon, Fletcher, J. Org. Chem. 26, 2892 (1961); Koeppen, Carbohydr. Res. 7, 410 (1968). Crystal structure: J. Ohanessian et al., Acta Crystallogr. B34, 3666 (1978).

Karanjin CAS Registry Number: 521-88-0 水黄皮次素

CAS Name: 3-Methoxy-2-phenyl-4H-furo[2,3-h]-1-benzopyran-4-one
Percent Composition: C 73.97%, H 4.14%, O 21.90%
Literature References: From Pongamia glabra Vent., Leguminosae: Beal, Katti, J. Am. Pharm. Assoc. 14, 1086 (1925); Rao, Rao, J. Indian Chem. Soc. 17, 526 (1940); Bhat et al., J. Am. Oil Chem. Soc. 33, 197 (1956). Structure: Limaye, Rasayanam 1, 1 (1936), C.A. 31, 22069 (1937); Manjunath et al., Ber. 72B, 39 (1939). Synthesis: Seshadri, Venkateswarlu, Proc. Indian Acad. Sci. 13A, 404 (1941); 17A, 16 (1943); Kawase et al., Bull. Chem. Soc. Jpn. 28, 273 (1955); Rao, Seshadri, Proc. Indian Acad. Sci. 33A, 168 (1951); Aneja et al., Tetrahedron 2, 203 (1958); Raizada et al., J. Sci. Ind. Res. 19B, 76 (1960).

Uranediol CAS Registry Number: 516-51-8 (1S,2R,4aS,4bR,6aS,8S,10aS,10bS,12aS)-2,10A,12A-三甲基-1,2,3,4,4A,4B,5,6,6A,7,8,9,10,10B,11,12-十六氢屈-1,8-二醇

CAS Name: (3b,5a,17a,17ab)-17-Methyl-D-homoandrostane-3,17a-diol
Percent Composition: C 78.69%, H 11.32%, O 9.98%
Literature References: From pregnant mares' urine: Marker et al., J. Am. Chem. Soc. 60, 210, 1061, 1561, 2719 (1938); Klyne, Biochem. J. 43, 611 (1948); Brooks et al., ibid. 51, 694 (1952). Structure: Klyne, Nature 166, 559 (1950). Formation by acid hydrolysis of 5a-pregnane-3b,20b-diol: Hirschmann, Williams, J. Biol. Chem. 238, 2305 (1963). Configuration: Hirschmann et al., J. Org. Chem. 31, 375 (1966).

Pterocarpin CAS Registry Number: 524-97-0

CAS Name: (6aR-cis)-6a,12a-Dihydro-3-methoxy-6H-[1,3]dioxolo[5,6]benzofuro[3,2-c][1]benzopyran
Percent Composition: C 68.45%, H 4.73%, O 26.82%
Literature References: From red sandalwood (Pterocarpus santalinus L.f., Leguminosae): Cazeneuve, Hugouneng, Compt. Rend. 104, 1722 (1887); 107, 737 (1888); Leonhardt, Fay, Arch. Pharm. 273, 53 (1935); McGookin et al., J. Chem. Soc. 1940, 787; from Pterocarpus spp: King et al., ibid. 1953, 3693. Structure: Bredenberg, Shoolery, Tetrahedron Lett. 1961, 285. Synthesis of the dl-form: Fukui, Nakayama, ibid. 1966, 1805; eidem, Bull. Chem. Soc. Jpn. 42, 1408 (1969); Uchiyama, Matsui, Agric. Biol. Chem. 31, 1490 (1967). Stereochemistry: Ito et al., Chem. Commun. 1965, 595; Pachler, Underwood, Tetrahedron 23, 1817 (1967).

Apocynin CAS Registry Number: 498-02-2 香草乙酮

CAS Name: 1-(4-Hydroxy-3-methoxyphenyl)ethanone
Additional Names: acetovanillon; 4-hydroxy-3-methoxyacetophenone
Percent Composition: C 65.05%, H 6.07%, O 28.88%
Literature References: From rhizome of Canadian hemp, Apocynum cannabinum L., Apocynaceae and from A. androsaemifolium: Finnemore, J. Chem. Soc. 93, 1513, 1520 (1908). Also from the essential oil (butter) of the rhizomes of Iris spp., Iridaceae: Naves, Helv. Chim. Acta 32, 1351 (1949).

Irigenin CAS Registry Number: 548-76-5 野鸢尾黄素

CAS Name: 5,7-Dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
Additional Names: 3',5,7-trihydroxy-4',5',6-trimethoxyisoflavone
Percent Composition: C 60.00%, H 4....
Literature References: From rhizome of Iris florentina L., Iridaceae: de Laire, Tiemann, Ber. 26, 2010 (1893). Structure: Baker, J. Chem. Soc. 1928, 1022. Synthesis: Baker et al., Tetrahedron Lett. no. 5, 6 (1960); Farkas, Várady, Ber. 93, 2685 (1960); Baker et al., J. Chem. Soc. C 1970, 1219.

Nupharidine CAS Registry Number: 468-89-3 (+)-萍蓬汀

CAS Name: [1R-(1a,4b,5a,7b,9aa)]-4-(3-Furanyl)octahydro-1,7-dimethyl-2H-quinolizine 5-oxide
Percent Composition: C 72.25%, H 9.30%, N 5.62%, O 12.83%
Literature References: From rhizome of Nuphar luteum (L.) Sibth. Sm. (Nymphaea lutea L.), Nymphaeaceae: Goris, Crété, Bull. Sci. Pharmacol. 17, 13 (1910). Isoln from N. japonicum DC., Nymphaeaceae and structure: Kotake et al., Ann. 606, 148 (1957). Total synthesis: Kotake et al., Bull. Chem. Soc. Jpn. 35, 698 (1962). Abs configuration: Kawasaki et al., ibid. 41, 1264 (1968); La Londe et al., J. Am. Chem. Soc. 93, 2501 (1971). Determn of crystal structure, abs config and stereochemistry by x-ray diffraction methods: J. Ohrt et al., J. Cryst. Mol. Struct. 3, 3 (1973).

Osthole CAS Registry Number: 484-12-8 蛇床子素

CAS Name: 7-Methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one
Additional Names: 7-methoxy-8-(3-methyl-2-butenyl)coumarin; 8-(3-methyl-2-butenyl)herniarin
Percent Composition: C 73.75%, H ...
Literature References: From rhizome of Peucedanum ostruthium (L.) Koch (Imperatoria ostruthium L.) Umbelliferae: Herzog, Krohn, Arch. Pharm. 247, 553 (1909); Butenandt, Marten, Ann. 495, 187 (1932); from Prangos pabularia Lindl., Umbelliferae: Pigulevskii, Kuznetsova, Dokl. Akad. Nauk SSSR 61, 309 (1948), C.A. 43, 3416d (1949); from Flindersia bennettiana F. Muell., Rutaceae: Galbraith et al., Aust. J. Chem. 13, 427 (1960). Structure: Späth, Pesta, Ber. 66, 754 (1933). Synthesis: Späth, Holzen, ibid. 67, 264 (1934); Murayama et al., Chem. Pharm. Bull. 20, 741 (1972).

Ostruthol CAS Registry Number: 642-08-0 欧前胡醇

CAS Name: (2Z)-2-Methyl-2-butenoic acid (1R)-2-hydroxy-2-methyl-1-[[(7-oxo-7H-furo[3,2-g][1]benzopyran-4-yl)oxy]methyl]propyl ester
Percent Composition: C 65.28%, H 5.74%, O 28.98%
Literature References: From rhizome of Peucedanum ostruthium L. Koch (Imperatoria ostruthium L.), Umbelliferae: Herzog, Koch, Arch. Pharm. 247, 553 (1909). Structure: Späth, Christiani, Ber. 66, 1150 (1933). Synthesis: Chatterjee, Dutta, Sci. Cult. 34, 460 (1968).

Irisolone CAS Registry Number: 3301-68-6 7-(4-羟基苯基)-9-甲氧基吡喃并[2,3-f][1,3]苯并二氧戊环-8-酮

CAS Name: 7-(4-Hydroxyphenyl)-9-methoxy-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one
Additional Names: Sosan; 4'-hydroxy-5-methoxy-6,7-methylenedioxyisoflavone
Percent Composition: C 65.39%, H 3...
Literature References: From rhizomes of Iris nepalensis D. Don, Iridaceae. Isoln and structure: Gopinath et al., Tetrahedron 16, 201 (1961). Synthesis: Fukui, Matsumato, Bull. Chem. Soc. Jpn. 38, 887 (1965).