其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bulbocapnine CAS Registry Number: 298-45-3 空褐麟碱

CAS Name: (7aS)-6,7,7a,8-Tetrahydro-11-methoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-12-ol
Additional Names: 10-methoxy-1,2-(methylenedioxy)-6aa-aporphin-11-ol
Percent Comp...
Literature References: From root of Corydalis cava (L.) Schweigg. Körte (C. tuberosa DC), Fumariaceae and Dicentra canadensis Walp., Papaveraceae. Isoln: Freund, Josephi, Ber. 25, 2411 (1892); Manske, Can. J. Res. 7, 258 (1932). Pharmacology and toxicity study: H. Molitar, J. Pharmacol. Exp. Ther. 56, 85 (1936). Structure: Gadamer, Chem. Ztg. 34, 1004 (1910). Configuration: Ayer, Taylor, J. Chem. Soc. 1956, 472; Corrodi, Hardegger, Helv. Chim. Acta 39, 889 (1956). Synthesis: Kikkawa, C.A. 54, 4649b (1960). Peripheral-dopamine-receptor blocking activity: R. G. Pendleton et al., Arch. Pharmacol. 289, 171 (1975).

Cynanchogenin CAS Registry Number: 6870-10-6 (3beta,9Xi,12beta,14beta,17alpha)-3,8,14-三羟基-20-氧代孕甾-5-烯-12-基(2E)-3,4-二甲基-2-戊烯酸酯

CAS Name: (3b,12b,14b,17a)-12-[(3,4-Dimethyl-1-oxo-2-pentenyl)oxy]-3,8,14-trihydroxypregn-5-en-20-one
Percent Composition: C 70.86%, H 8.92%, O 20.23%
Literature References: From root of Cynanchum caudatum Max., Asclepiadaceae: Mitsuhashi, Shimizu, Chem. Pharm. Bull. 8, 313, 318 (1960). Proposed structure: eidem, Steroids 2, 373 (1963). Revised structure: eidem, Tetrahedron 24, 4143 (1968). 13C-NMR studies: T. Yamagishi et al., Tetrahedron Lett. 1973, 3527, 3531.

Gentisin CAS Registry Number: 437-50-3 龙胆根素

CAS Name: 1,7-Dihydroxy-3-methoxy-9H-xanthen-9-one
Additional Names: 4,7-dihydroxy-2-methoxyxanthone; gentianic acid; gentianin; gentiin
Percent Composition: C 65.12%, H 3.90%, O 30.98%
Literature References: From root of Gentiana lutea L., Gentianaceae: Henry, Caventou, J. Pharm. Chim. 1821, 178; Canonica, Pelizzoni, Gazz. Chim. Ital. 85, 1007 (1955). Structure: Korte, Ber. 87, 1357 (1954). Synthesis: Anand, Venkataraman, Proc. Indian Acad. Sci. 25A, 438 (1947); Rao, Seshadri, ibid. 37A, 710 (1953).

Laserpitin CAS Registry Number: 7067-12-1 二[(Z)-2-甲基-2-丁烯酸](1R,8aR)-十氢-1,6alpha-二羟基-3abeta,6-二甲基-1-(1-甲基乙基)-5-氧代-4alpha,8alpha-薁二基酯

CAS Name: [1R-[1a,3aa,4b(Z),6b,8b(Z),8ab]]-2-Methyl-2-butenoic acid decahydro-1,6-dihydroxy-3a,6-dimethyl-1-(1-methylethyl)-5-oxo-4,8-azulenediyl ester
Percent Composition: C 66.64%, H 8.50%, O...
Literature References: From root of Laserpitium latifolium L., Umbelliferae: Külz, Arch. Pharm. 221, 161 (1883); Morgenstern, Monatsh. Chem. 33, 709 (1912). Structure: M. Holub et al., Tetrahedron Lett. 1965, 1441, 2855. Absolute configuration: M. Holub et al., Collect. Czech. Chem. Commun. 35, 3597 (1970).

Nodakenin CAS Registry Number: 495-31-8 紫花前胡苷

CAS Name: 2-[1-(b-D-Glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one
Additional Names: nodakenetin glucoside
Percent Composition: C 58.82%, H 5.92%, O 35.26%
Literature References: From root of Peucedanum decursivum Maxim., Umbelliferae: Arima, Bull. Chem. Soc. Jpn. 4, 16, 113 (1929); Späth, Kainrath, Ber. 69, 2062 (1936). Structure: Späth, Tyray, ibid. 72, 2089 (1939).

Yangonin CAS Registry Number: 500-62-9 甲氧醉椒素

CAS Name: (E)-4-Methoxy-6-[2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one
Additional Names: 4-methoxy-6-(p-methoxystyryl)-2H-pyran-2-one; 5-hydroxy-3-methoxy-7-(p-methoxyphenyl)-2,4,6-heptatrienoic...
Literature References: From root of Piper methysticum Forst., Piperaceae (kava): Winzhermer, Arch. Pharm. 246, 338 (1908); Borsche, Gerhardt, Ber. 47, 2902 (1914). From Ranunculus quelpaertensis Nakai, Ranunculaceae: Shibata et al., Bull. Chem. Soc. Jpn. 45, 930 (1972). Structure: Chmielewska et al., Tetrahedron 4, 36 (1958); Bu'Lock, Smith, J. Chem. Soc. 1960, 502. Synthesis: Harris, Combs, J. Org. Chem. 33, 2399 (1968); R. Bacardit, J. Heterocycl. Chem. 19, 157 (1982). Molecular and crystal structure: Engel, Nowacki, Z. Kristallogr. Kristallgeom. Kristallphys. Kristallchem. 134, 180 (1971). Activity studies: Kretzschmar et al., Arch. Int. Pharmacodyn. Ther. 180, 471 (1969).

Senegenin CAS Registry Number: 2469-34-3 远志皂苷元

CAS Name: (2b,3b,4a,12a)-12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid
Percent Composition: C 67.08%, H 8.44%, Cl 6.60%, O 17.87%
Literature References: From root of Polygala senega Linn., Polygalaceae: Jacobs, Isler, J. Biol. Chem. 119, 155 (1937). Structure studies: Shamma, Reiff, Chem. Ind. (London) 1960, 1272; Dugan et al., Can. J. Chem. 42, 491 (1964). Structure: Dugan et al., Proc. Chem. Soc. London 1964, 264. Formation from presenegenin: Pelletier et al., Chem. Commun. 1966, 727.

Rhapontin CAS Registry Number: 155-58-8 勒胖停; 土大黄苷

CAS Name: (E)-3-Hydroxy-5-[2-(3-hydroxy-4-methoxyphenyl)ethenyl]phenyl b-D-glucopyranoside
Additional Names: 4'-methoxy-3,3',5-stilbenetriol 3-glucoside; rhaponticin; ponticin
Percent Compos...
Literature References: From root of Rheum rhaponticum L., Polygonaceae: Hesse, J. Prakt. Chem. 77, 321 (1908); Schürhoff, Plettner, Arch. Pharm. 275, 281 (1937). On hydrolysis yields rhapontigenin and glucose: Kawamura, J. Pharm. Soc. Jpn. 58, 405 (1938), C.A. 32, 66554 (1938). Constitution of rhapontigenin: Takaoka, Proc. Imp. Acad. Tokyo 16, 408 (1940), C.A. 35, 13992 (1941).

Bergenin CAS Registry Number: 477-90-7 岩白菜素

CAS Name: 3,4,4a,10b-Tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyrano[3,2-c][2]benzopyran-6(2H)-one
Additional Names: 4-methoxy-2-[tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl...
Literature References: From root of Saxifraga (Bergenia) crassifolia L., and from rhizome of S. sibirica L. Saxifragaceae: Morelle, Compt. Rend. 93, 646 (1881); Ber. 14, 2694 (1881); Ssadikow, Guthner, Biochem. Z. 190, 340 (1927); Tschitschibabin et al., Ann. 469, 93 (1929). Identity with vakerin: Carruthers et al., Chem. Ind. (London) 1957, 76. Identity with ardisic acid B: Hung, Chu, C.A. 52, 15827h (1958). Identity with cuscutin: Jain, Mishra, Indian J. Chem. 1, 499 (1963). Identity with peltophorin: Joshi, Kamat, Naturwissenschaften 56, 89 (1969). Structure: Posternak, Dürr, Helv. Chim. Acta 41, 1159 (1958); Fujise et al., Bull. Chem. Soc. Jpn. 32, 97 (1959). Synthesis and structure: Hay, Haynes, J. Chem. Soc. 1958, 2231. Biosynthesis: Wenkert, Chem. Ind. (London) 1959, 906.

Tetrandrine CAS Registry Number: 518-34-3 汉防己甲素; 粉防己碱

CAS Name: (1b)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman
Percent Composition: C 73.29%, H 6.80%, N 4.50%, O 15.41%
Literature References: From root of Stephania tetrandra S. Moore, Menispermaceae. Isoln: Kondo, Yano, Ann. 497, 90 (1932). Structure: Fujita, Murai, J. Pharm. Soc. Jpn. 71, 1039 (1951). Synthesis: Kataoka, C.A. 51, 16501i (1957). Total synthesis: Inubushi et al., Tetrahedron Lett. 1968, 3399; eidem, J. Chem. Soc. C 1969, 1547. Present in the Chinese drug han-fang-chi.