其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Hydroxylupanine CAS Registry Number: 15358-48-2 13-羟基羽扇豆碱

CAS Name: [2S-(2a,7b,7ab,14b,14aa)]-Dodecahydro-2-hydroxy-7,14-methano-2H,11H-dipyrido[1,2-a:1',2'-e][1,5]diazocin-11-one
Additional Names: octalupine; oxylupanine; 13-hydroxylupanine
Percen...
Literature References: From seed of Lupinus perennis L., L. angustifolius L. and L. polyphyllus Lindl., Leguminosae: Rink, Schäfer, Arch. Pharm. 287, 290 (1954); Winterfeld, Pies, ibid. 290, 537 (1957); Bohlmann, Winterfeldt, Ber. 93, 1956 (1960). Structure: Galinovsky et al., Monatsh. Chem. 81, 77 (1950). Biosynthesis: Schuette et al., Arch. Pharm. 296, 438 (1963).

Ormosinine CAS Registry Number: 14350-67-5

CAS Name: 21-Ormosanin-20-yl panamine
Percent Composition: C 76.14%, H 10.54%, N 13.32%
Literature References: From seed of Ormosia dasycarpa Jacks., Leguminosae: Hess, Merck, Ber. 52, 1976 (1919); from O. panamensis Benth., Leguminosae: Lloyd, Horning, J. Am. Chem. Soc. 80, 1506 (1958). Structural studies: Wilson, Chem. Ind. (London) 1965, 472; Tetrahedron 21, 2561 (1965). Composed of one molecule of panamine and one molecule of ormosanine; NMR elucidation of structure: N. S. Bhacca et al., J. Am. Chem. Soc. 105, 2538 (1983).

Physovenine CAS Registry Number: 6091-05-0

CAS Name: (3aS-cis)-3,3a,8,8a-Tetrahydro-3a,8-dimethyl-2H-furo[2,3-b]indol-5-ol methylcarbamate (ester)
Percent Composition: C 64.11%, H 6.92%, N 10.68%, O 18.30%
Literature References: From seed of Physostigma venenosum Balf., Leguminosae: Salway, J. Chem. Soc. 99, 2148 (1911). Structure: Robinson, ibid. 1964, 1503. Synthesis: Longmore, Robinson, Chem. Ind. (London) 1965, 1297. Abs config: eidem, ibid. 1969, 622.

Vomicine CAS Registry Number: 125-15-5 番木虌次碱

CAS Name: 4-Hydroxy-19-methyl-16,19-secostrychnidine-10,16-dione
Additional Names: 12-hydroxy-N-methylpseudostrychnine
Percent Composition: C 69.46%, H 6.36%, N 7.36%, O 16.82%
Literature References: From seed of Strychnos nux vomica L., Loganiaceae: Wieland, Oertel, Ann. 469, 193 (1929). Structure: Huisgen et al., ibid. 573, 121 (1951). Synthesis: Rosenmund, Angew. Chem. 75, 1127 (1963). Reviews: R. Robinson in Progress in Organic Chemistry vol. I (Butterworths, London, 1952) pp 2-21; J. B. Hendrickson in The Alkaloids vol. VI, R. H. F. Manske, H. L. Holmes, Eds. (Academic Press, New York, 1960) pp 195-204.

Helenynolic Acid CAS Registry Number: 7309-58-2

CAS Name: (9S,10E)-9-Hydroxy-10-octadecen-12-ynoic acid
Percent Composition: C 73.43%, H 10.27%, O 16.30%
Literature References: From seed oil of Helichrysum bracteatum Andr., Compositae: R. G. Powell et al., J. Am. Oil Chem. Soc. 42, 165 (1965). Structure: eidem, J. Org. Chem. 30, 610 (1965). Absolute configuration: J. C. Craig et al., ibid. 4342. Partial synthesis of racemic helenynolic acid: H. R. S. Conacher, Gunstone, Lipids 5, 137 (1970). Synthesis of (±)-form: T. B. Patrick, G. F. Melm, J. Org. Chem. 44, 645 (1979).

Khellol Glucoside CAS Registry Number: 17226-75-4 糖呋色酮

CAS Name: 7-[(b-D-Glucopyranosyloxy)methyl]-4-methoxy-5H-furo[3,2-g][1]benzopyran-5-one
Additional Names: 2-hydroxymethyl-5-methoxyfuranochrome glucoside; khellinin
Percent Composition: C 55...
Literature References: From seeds of Ammi visnaga Lam., Umbelliferae: Späth, Gruber, Ber. 74, 1549 (1941); Illing, Arzneim.-Forsch. 7, 497 (1957); from Eranthis hyemalis L., Ranunculaceae: Egger, Z. Naturforsch. 16B, 697 (1962). Structure: Fabbrini, Franchi, Ann. Chim. (Rome) 49, 894 (1959), C.A. 54, 4558f (1960).

Arecaidine CAS Registry Number: 499-04-7 1,2,5,6-四氫-1-甲菸鹼酸

CAS Name: 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid
Additional Names: 1,2,5,6-tetrahydro-1-methylnicotinic acid; arecaine; methylguvacine
Percent Composition: C 59.56%, H 7.85%, ...
Literature References: From seeds of Areca catechu L., Palmaceae (betel nuts). Synthesis: Wohl, Johnson, Ber. 40, 4712 (1907); Hess, Leibbrandt, ibid. 51, 806 (1918); Freudenberg, ibid. 976; Maurit, Preobrazhenskii, Zh. Obshch. Khim. 28, 968 (1958), C.A. 52, 17263 (1958); Merck, DE 485139 C.A. 24, 919 (1930).

Conhydrine CAS Registry Number: 495-20-5 羟毒芹碱

Additional Names: [R-(R*,S*)]-a-Ethyl-2-piperidinemethanol; 2-(a-hydroxypropyl)piperidine
Percent Composition: C 67.08%, H 11.96%, N 9.78%, O 11.17%
Literature References: From seeds of Conium maculatum L., Umbelliferae. Isoln: Späth, Adler, Monatsh. Chem. 63, 127 (1933). Stereochemistry: Hill, J. Am. Chem. Soc. 80, 1609 (1958); Sicher, Ticky, Collect. Czech. Chem. Commun. 23, 2081 (1958).

Delsoline CAS Registry Number: 509-18-2 硬飞燕草碱

CAS Name: (1a,6b,14a,16b)-20-Ethyl-6,14,16-trimethoxy-4-(methoxymethyl)aconitane-1,7,8-triol
Percent Composition: C 64.21%, H 8.84%, N 3.00%, O 23.95%
Literature References: From seeds of Dephinium consolida L., Ranunculaceae: Markwood, J. Am. Pharm. Assoc. 13, 696 (1924); Cionga, Iliescu, Ber. 74, 1031 (1941); Marion, Edwards, J. Am. Chem. Soc. 69, 2010 (1947). Structure: Anet et al., Can. J. Chem. 35, 397 (1957); Skaric, Marion, J. Am. Chem. Soc. 80, 4434 (1958); eidem, Can. J. Chem. 38, 2433 (1960); 39, 1579 (1961).

Ajaconine CAS Registry Number: 545-61-9 阿加康宁

Percent Composition: C 73.50%, H 9.25%, N 3.90%, O 13.35%
Literature References: From seeds of larkspur, Delphinium ajacis L., Ranunculaceae: Keller, Volker, Arch. Pharm. 251, 207 (1913); Goodson, J. Chem. Soc. 1945, 245. Structure: Dvornik, Edwards, Tetrahedron 14, 54 (1961); Nabors et al., Tetrahedron Lett. 1969, 2445. Stereochemistry: Solo, Pelletier, Chem. Ind. (London) 1960, 1108; Whalley, Tetrahedron 18, 43 (1962). Synthetic studies: Nabors et al., ibid. 27, 2385 (1971). Rearrangement: S. W. Pelletier, N. V. Mody, J. Am. Chem. Soc. 101, 492 (1979).