其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Alstonidine CAS Registry Number: 25394-75-6 甲基(2S,3S,4S)-3-(羟基甲基)-2-甲基-4-[(9-甲基-9H-beta-咔啉-1-基)甲基]-3,4-二氢-2H-吡喃-5-羧酸酯

CAS Name: 3b-(Hydroxymethyl)-2a-methyl-4b-[(9-methyl-9H-pyrido[3,4-b]indol-1-yl)methyl]-2H-pyran-5-carboxylic acid methyl ester
Percent Composition: C 69.46%, H 6.36%, N 7.36%, O 16.82%
Literature References: From the bark or root of Alstonia constricta F. Muell., Apocynaceae: Hesse, Ann. 205, 360 (1880); Svoboda, J. Am. Pharm. Assoc. 46, 508 (1957). Structure: Boaz et al., ibid. 510. Stereochemistry: Crow et al., Aust. J. Chem. 23, 2489 (1970).

Vacciniin CAS Registry Number: 90-75-5 ((2R,3S,4S,5R,6R)-3,4,5,6-四羟基四氢-2H-吡喃-2-基)苯甲酸甲酯

CAS Name: b-D-Glucopyranose 6-benzoate
Additional Names: 6-benzoyl-D-glucose
Percent Composition: C 54.93%, H 5.67%, O 39.40%
Literature References: From the berries of Vaccinium vitisidaea L., V. macrocarpum Ait., and V. oxycoccus L., Ericaceae: Griebel, Z. Untersuch. Nahr. Genussm. 19, 241 (1910); Brigl, Zerrweck, Z. Physiol. Chem. 229, 117 (1934). Prepn and chromatography: Bock et al., Nahrung 3, 1036 (1960).

Sparsiflorine CAS Registry Number: 2128-61-2 2-甲氧基-5,6,6A,7-四氢-4H-二苯并[去,G]喹啉-1,10-二醇

CAS Name: 5,6,6a,7-Tetrahydro-2-methoxy-4H-dibenzo[de,g]quinoline-1,10-diol
Additional Names: 2-methoxy-6ab-noraporphine-1,10-diol
Percent Composition: C 72.07%, H 6.05%, N 4.94%, O 16.94%
Literature References: From the leaves of Croton sparsiflorus Morung, Euphorbiaceae: Saha, Sci. Cult. 24, 572 (1959), C.A. 54, 1580a (1960). Structure: Chatterjee et al., Tetrahedron Lett. 1965, 1539.

Ocimene CAS Registry Number: 29714-87-2

Percent Composition: C 88.16%, H 11.84%
Literature References: From the leaves of Ocimum basilicum L., Labiatae; Baronia dentigeroides Cheel, Rutaceae; Litsea zeylanica C. T. Nees, Lauraceae; Homoranthus flavescens A. Cunn., Myrtaceae. From the fruits of Evodia rutaecarpa (Juss.) Hook. f. Thoms., Rutaceae. Exists in two modifications: a-form, 3,7-dimethyl-1,3,7-octatriene; and b-form, 3,7-dimethyl-1,3,6-octatriene. Cis and trans refers to the stereochemistry at the double bond between positions 3 and 4. Isoln and structure: van Romburgh, Proc. K. Ned. Akad. Wet. 3, 454 (1900); Enklaar, Rec. Trav. Chim. 26, 157 (1907); 27, 422 (1908); 36, 215 (1917); 45, 337 (1926). Structure: Sutherland, J. Am. Chem. Soc. 74, 2688 (1952). Separation of isomers: Ohloff et al., Ann. 675, 83 (1964). Synthesis of trans-a-form: O. P. Vig et al., Indian J. Chem. 7, 1111 (1969). Stereospecific synthesis: O. P. Vig et al., ibid. 15B, 25 (1977).

Ostruthin CAS Registry Number: 148-83-4 (E)-6-(3,7-二甲基辛-2,6-二烯-1-基)-7-羟基-2H-色烯-2-酮

CAS Name: (E)-6-(3,7-Dimethyl-2,6-octadienyl)-7-hydroxy-2H-1-benzopyran-2-one
Additional Names: (E)-6-(3,7-dimethyl-2,6-octadienyl)-7-hydroxycoumarin; 6-(3,7-dimethyl-2,6-octadienyl)umbellifero...
Literature References: From the root of Peucedanum ostruthium (L.) Koch (Imperatoria ostruthium L.), Umbelliferae: Butenandt, Marten, Ann. 495, 187 (1932); from Eriostemon tomentellus, Rutaceae: Duffield, Jeffries, Aust. J. Chem. 16, 123 (1963). Structure: Späth, Klager, Ber. 67, 859 (1934); Späth, Kainrath, ibid. 70, 2272 (1937).

Pelletierine CAS Registry Number: 4396-01-4 石榴根皮碱

CAS Name: 1-(2-Piperidinyl)-2-propanone
Additional Names: 2-acetonylpiperidine; punicine
Percent Composition: C 68.04%, H 10.71%, N 9.92%, O 11.33%
Literature References: From the rootbark of the pomegranate tree, Punica granatum L., Punicaceae. Isoln: Tanret, Compt. Rend. 86, 1270 (1878). Structure: Gilman, Marion, Bull. Soc. Chim. Fr. 1961, 1993; Drillien, Viel, ibid. 1963, 2393. Abs config: H. C. Beyerman et al., Rec. Trav. Chim. 86, 80 (1967). Synthesis: Anet et al., Nature 164, 501 (1949); T. Nagasaka et al., Heterocycles 29, 155 (1989).

Akuammicine CAS Registry Number: 639-43-0 (19E)-2,16,19,20-四去氢枯苒-17-酸甲酯

CAS Name: 2,16,19-20-Tetradehydrocuran-17-oic acid methyl ester
Percent Composition: C 74.51%, H 6.88%, N 8.69%, O 9.93%
Literature References: From the seeds of Picralima klaineana, Pierre, Apocynaceae found in the Gold Coast: Henry, Sharp, J. Chem. Soc. 1927, 1950; Henry, ibid. 1932, 2759. Structure: Aghoramurthy, Robinson, Tetrahedron 1, 172 (1957); Bernauer et al., Helv. Chim. Acta 43, 717 (1960); Edwards, Smith, J. Chem. Soc. 1961 152. Derivs: Robinson, Thomas, ibid. 1955, 2049. Total synthesis: Kutney, Fuller, Heterocycles 3, 197 (1975).

Nicotelline CAS Registry Number: 494-04-2 3,2':4',3''-联三吡啶

CAS Name: 3,2':4',3''-Terpyridine
Additional Names: 2,4-di(3-pyridyl)pyridine; 2,4-di(b-pyridyl)pyridine
Percent Composition: C 77.23%, H 4.75%, N 18.01%
Literature References: From tobacco leaf: Pictet, Rotschy, Ber. 34, 696 (1901); Noga, Fach. Mitt. Tabakregie 1914, Nos. 1 and 2. Structure: Kuffner, Faderl, Monatsh. Chem. 87, 71 (1956). Synthesis: Thesing, Müller, Angew. Chem. 68, 577 (1956); Ber. 90, 711 (1957).

Lappaconitine CAS Registry Number: 32854-75-4 高乌甲素

CAS Name: (1a,14a,16b)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-[2-(acetylamino)benzoate]
Percent Composition: C 65.73%, H 7.58%, N 4.79%, O 21.89%
Literature References: From tubers and herb of Aconitum septentrionale Kölle, A. orientale Mill., A. excelsum Reichb., A. ranunculaefolium, Ranunculaceae: Schulze, Ulfert, Arch. Pharm. 260, 230 (1922); Kuzovkov, Massagetov; Platonova et al., Zh. Obshch. Khim. 25, 178 (1955); 28, 258 (1958), C.A. 50, 1852e (1956), C.A. 52, 12883i (1958), resp.; Mollov et al., Compt. Rend. Acad. Bulgare Sci. 17, 251 (1964), C.A. 61, 12324g (1964). Structure: Khaimova et al., Tetrahedron Lett. 1964, 2711. Revised structure: V. A. Tel'nov et al., Khim. Prir. Soedin. 6, 583 (1970), C.A. 74, 42527k (1971). Analgesic activity studies in mice and rats: N. Ono, J. Satoh, Arzneim.-Forsch. 38, 892 (1988). Toxicology: F. Dybing et al., Acta Pharmacol. Toxicol. 7, 337 (1951).

Pseudoaconitine CAS Registry Number: 127-29-7 乌头酸-3,8,13,14-四硝酸,20-乙基-1,6,16-三甲氧基-4-(甲氧基甲基)-,8-醋酸酯14-(3,4-二甲氧基苯甲酸盐),(1a,3a,6a,14a,16b)-

CAS Name: (1a,3a,6a,14a,16b)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14-tetrol 8-acetate 14-(3,4-dimethoxybenzoate)
Additional Names: acraconitine; feraconitine; nepaline; ...
Literature References: From tubers of Aconitum ferox Wall., Ranunculaceae. Ref: Wright, Luff, J. Chem. Soc. 33, 151 (1878); Dunstan, Carr, ibid. 71, 350 (1897); Henry, Sharp, ibid. 1928, 1105, 3094; K. Paech, M. V. Tracey, Modern Methods of Plant Analysis Vol. IV (Springer-Verlag, Berlin, 1955) p 375. Structure: Gilman, Marion, Tetrahedron Lett. 1962, 923. Stereochemistry: Tsuda, Marion, Can. J. Chem. 41, 1485 (1963).