其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Harmalol CAS Registry Number: 525-57-5 去甲骆驼蓬碱

CAS Name: 4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indol-7-ol
Additional Names: 3,4-dihydro-1-methyl-9H-pyrido[3,4-b]indol-7-ol
Percent Composition: C 71.98%, H 6.04%, N 13.99%, O 7.99%
Literature References: From seeds of Peganum harmala L., Zygophyllaceae: Göbel, Ann. 38, 363 (1841); Fischer, Ber. 18, 400 (1885); by demethylation of harmaline: Coulthard et al., Biochem. J. 27, 727 (1933). HPLC determn in Peganum harmala L. seeds: M. Kartal et al., J. Pharm. Biomed. Anal. 31, 263 (2003). In vitro neuroprotective effects: D. H. Kim et al., Eur. J. Neurosci. 13, 1861 (2001).

Sulforaphen CAS Registry Number: 592-95-0 (S)-萝卜丁酚

CAS Name: 4-Isothiocyanato-1-(methylsulfinyl)-1-butene
Additional Names: isothiocyanic acid 4-(methylsulfinyl)-3-butenyl ester; raphanin
Percent Composition: C 41.12%, H 5.18%, N 7.99%, O 9....
Literature References: From seeds of radish, Raphanus sativus L., Cruciferae: Ivanovics, Horvath, Nature 160, 297 (1947); Proc. Soc. Exp. Biol. Med. 66, 625 (1947). Identity with raphanin: Koczka, Ivanovics, C.A. 44, 5538c (1950). Structure: Schmid, Karrer, Helv. Chim. Acta 31, 1017 (1948). Synthesis of (±)-form: Balenovic et al., Tetrahedron 22, 2139 (1966).

Convicine CAS Registry Number: 19286-37-4 6-氨基-5-beta-D-吡喃葡萄糖基氧基尿嘧啶

CAS Name: 6-Amino-5-(b-D-glucopyranosyloxy)-2,4(1H,3H)-pyrimidinedione
Percent Composition: C 39.35%, H 4.95%, N 13.77%, O 41.93%
Literature References: From seeds of Vicia sativa L., Leguminosae: Ritthausen, J. Prakt. Chem. [2] 24, 202 (1881); Ber. 29, 894 (1896). Structure: Johnson, J. Am. Chem. Soc. 36, 337 (1914); Fisher, Johnson, ibid. 54, 2038 (1932); Bendick, Clements, Biochim. Biophys. Acta 12, 462 (1953); Bien et al., J. Chem. Soc. C 1968, 496. Synthesis: eidem, J. Chem. Soc. Perkin Trans. 1 1973, 1089.

Solasonine CAS Registry Number: 19121-58-5 澳洲茄碱

CAS Name: (3b,22a,25R)-Spirosol-5-en-3-yl O-6-deoxy-a-L-mannopyranosyl-(1®2)-O-[b-D-glucopyranosyl-(1®3)]-b-D-galactopyranoside
Additional Names: solanine-S; purapurine
Percent Composition: ...
Literature References: From Solanum aviculare Forst F., S. sodomeum L., S. xanthocarpum Schrad Wendl., Solanaceae: Bell, Briggs, J. Chem. Soc. 1942, 1; Briggs et al., ibid. 1942, 3; Kuhn, Löw, Ber. 88, 289 (1955). Isoln from other S. spp: Briggs, Cambie, J. Chem. Soc. 1958, 1422; Briggs et al., ibid. 1961, 4645. Paper chromatography: Szendey, Arch. Pharm. 290, 563 (1957). Structure: Briggs et al., J. Chem. Soc. 1963, 2848. Enzymic decompn: Guseva, Pasechnichenko, Biokhimiya 24, 563 (1959).

Solanocapsine CAS Registry Number: 639-86-1

CAS Name: (3b,5a,16a,22a,23b,25b)-3-Amino-16,23-epoxy-16,28-secosolanidan-23-ol
Additional Names: solanocapsin; 3b-amino-22,26-imino-16b,23-oxido-5a,22a,23b,25a-cholestan-23-ol; 3b-amino-22,26-...
Literature References: From Solanum pseudocapsicum L., S. capsicastrum Link, S. hendersonii hort., Solanaceae. Isolation: Barger, Fraenkel-Conrat, J. Chem. Soc. 1936, 1537; K. Schreiber, H. Ripperger, Z. Naturforsch. 17B, 217 (1962). Structure: eidem, Experientia 16, 536 (1960). Revised structure and synthesis: eidem, Ann. 723, 159 (1969). Stereochemistry: eidem, Tetrahedron Letters no. 27, 9 (1960); Ann. 655, 114 (1962). Synthesis: Ripperger et al., Tetrahedron Lett. 1970, 5251; eidem, Tetrahedron 28, 1629 (1972).

Picrocrocin CAS Registry Number: 138-55-6 苦番红花素

CAS Name: (4R)-4-(b-D-Glucopyranosyloxy)-2,6,6-trimethyl-1-cyclohexene-1-carboxaldehyde
Additional Names: saffron-bitter
Percent Composition: C 58.17%, H 7.93%, O 33.90%
Literature References: From stigmas of Crocus sativus L., Iridaceae. Isoln: Kayser, Ber. 17, 2228 (1884). Structure: Kuhn, Winterstein, Ber. 67, 344 (1934). Exerts sex-determining influences in the plant organism: Kuhn, Angew. Chem. 53, 1 (1940). Its moieties are glucose and safranal, q.q.v. Abs config: Buchecker, Eugster, Helv. Chim. Acta 56, 1121 (1973). Synthesis: H. Mayer, J.-M. Santer, Helv. Chim. Acta 63, 1463 (1980).

Diaboline CAS Registry Number: 509-40-0 达波灵碱

CAS Name: 1-Acetyl-19,20-didehydro-17,18-epoxycuran-17-ol
Additional Names: N-acetyl-Wieland-Gumlich aldehyde
Percent Composition: C 71.57%, H 6.86%, N 7.95%, O 13.62%
Literature References: From Strychnos diaboli Sandw., Loganiaceae: King, J. Chem. Soc. 1949, 955; Bader et al., Helv. Chim. Acta 36, 1256 (1953); Casinovi et al., Nature 193, 1178 (1962). Structure: Battersby, Hodson, Proc. Chem. Soc. London 1959, 123. Synthesis: Deyrup et al., Helv. Chim. Acta 45, 2266 (1962). 13C-NMR study: E. Wenkert et al., J. Org. Chem. 43, 1099 (1978).

Flavopereirine CAS Registry Number: 486-18-0

CAS Name: 3-Ethyl-12H-indolo[2,3-a]quinolizin-5-ium inner salt
Additional Names: melinonine G
Percent Composition: C 82.90%, H 5.73%, N 11.37%
Literature References: From Strychnos melinoniana Baillon., Loganiaceae: Bächli et al., Helv. Chim. Acta 40, 1167 (1957); from Geissospermum vellosii Baillon., Apocynaceae: Rapoport et al., J. Am. Chem. Soc. 80, 1601 (1958). Bertho et al., Ber. 91, 2581 (1958). Structure: Bejar et al., Compt. Rend. 244, 2066 (1957). Synthesis: Le Hir et al., Bull. Soc. Chim. Fr. 1958, 551; Prasad, Swan, J. Chem. Soc. 1958, 2024; G. W. Gribble, D. A. Johnson, Tetrahedron Lett. 28, 5259 (1987); of perchlorate: J. Ninomiyo et al., Heterocycles 9, 1527 (1978).

Hamamelose CAS Registry Number: 4573-78-8 D-金缕梅糖

CAS Name: 2-C-(Hydroxymethyl)-D-ribose
Percent Composition: C 40.00%, H 6.71%, O 53.28%
Literature References: From tannin of witch hazel (Hamamelis virginiana L., Hamamelidaceae): Fischer, Freudenberg, Ber. 45, 2709 (1912); Freudenberg, Peters, ibid. 53, 953 (1920); Anderson, U.S.A.E.C. UCRL-8870, 114 (1959). Structure: Schmidt, Ann. 476, 250 (1929). Configuration: Schmidt, Heintz, ibid. 515, 77 (1934). Synthesis: Novák, Sorm, Collect. Czech. Chem. Commun. 30, 3303 (1965); Paulsen et al., Ber. 105, 1978 (1972). Synthesis of L-hamamelose: Burton et al., Proc. Chem. Soc. London 1962, 181. Synthesis and 1H, 13C NMR study of aqueous equilibrium: W. A. Szarek et al., Can. J. Chem. 61, 461 (1983).

Cinchonamine CAS Registry Number: 482-28-0 金鸡纳胺

CAS Name: [1S-(1a,2a,4a,5b)]-2-(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)-1H-indole-3-ethanol
Additional Names: 3-(b-hydroxyethyl)-2-(5-vinyl-2-quinuclidyl)indole
Percent Composition: C 76.99%,...
Literature References: From the bark of Remijia purdieana Wedd., Rubiaceae: Arnaud, Compt. Rend. 93, 593 (1881); Hesse, Ann. 225, 211 (1884). Prepn by reduction of quinamine with lithium aluminum hydride and structure: Goutarel et al., Helv. Chim. Acta 33, 150 (1950). Synthesis: Chen et al., C.A. 53, 7219e (1959). Total synthesis: G. Grethe et al., Helv. Chim. Acta 59, 2271 (1976). Stereochemistry: Wenkert, Bringi, J. Am. Chem. Soc. 80, 3484 (1958); Augustine, Chem. Ind. (London) 1959, 1071; Sawa, Matsumura, Tetrahedron 26, 2923 (1970). Biosynthetic studies: Battersby, Parry, Chem. Commun. 1971, 31. Conversion of chinchona alkaloids of the quinoline series to those of the indole series: Ochiai et al., C.A. 59, 14040h (1963).