其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Stylopine CAS Registry Number: 7461-02-1 四氢黄连碱

CAS Name: 6,7,12b,13-Tetrahydro-4H-bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizine
Additional Names: 2,3:9,10-bis(methylenedioxy)-13a-berbine; tetrahydrocoptisine
Percent Composition: C 70.58...
Literature References: From root of Stylophorum diphyllum (Michx.) Nutt, Corydalis cava Schwg. and Chelidonium majus L., Papaveraceae: Schlotterbeck, Watkins, Ber. 35, 7 (1902); Späth, Julian, Ber. 64, 1131 (1931); Manske, Can. J. Res. B20, 53 (1942); Slavik, Collect. Czech. Chem. Commun. 20, 198 (1955); Bandelin, Malesh, J. Am. Pharm. Assoc. 45, 702 (1956); Slavik, Collect. Czech. Chem. Commun. 26, 2933 (1961).

Bikhaconitine CAS Registry Number: 6078-26-8

CAS Name: (1a,6a,14a,16b)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-8,13,14-triol 8-acetate 14-(3,4-dimethoxybenzoate)
Additional Names: acetylveratroylbikhaconine
Percent Compos...
Literature References: From roots of Aconitum spicatum Stapf., Ranunculaceae: Dunstan, Andrews, J. Chem. Soc. 87, 1636 (1905). Structure: Tsuda, Marion, Can. J. Chem. 41, 3055 (1963).

Imperatorin CAS Registry Number: 482-44-0 欧前胡素

CAS Name: 9-[(3-Methyl-2-butenyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one
Additional Names: 6-hydroxy-7-(3-methyl-2-butenyloxy)-5-benzofuranacrylic acid d-lactone; 8-isoamylenoxypsoralen; marmelo...
Literature References: From roots of Imperatoria osthruthium L., Umbelliferae: Späth, Holzen, Ber. 66, 1137 (1933); from seeds of Angelica archangelica L.: Späth, Vierhapper, ibid. 71, 1667 (1938); from fruit of Pastinaca sativa L., Umbelliferae: Soine et al., J. Am. Pharm. Assoc. 45, 426 (1956). Identity with marmelosin: Späth et al., Ber. 70, 1021 (1937). Identity with ammidin: Fahmy, Abu-Shady, Q. J. Pharm. Pharmacol. 21, 499 (1948). Partial synthesis: Späth, Holzen, Ber. 68, 1123 (1935). Synthesis: Späth, Vierhapper, ibid. 70, 248 (1937).

Ajmaline CAS Registry Number: 4360-12-7 阿马灵,阿义马林

CAS Name: Ajmalan-17,21-diol
Additional Names: rauwolfine
Trademarks: Aritmina (Altana); Gilurytmal (Solvay); Ritmos (Sanofi-Synthelabo); Tachmalin (AWD)
Percent Composition: C 73.59%, H ...
Literature References: From roots of Rauwolfia serpentina (L.) Benth. (Ophioxylon serpentinum L.), Apocynaceae. Isolation: S. Siddiqui, R. H. Siddiqui, J. Indian Chem. Soc. 8, 667 (1931); 9, 539 (1932); 12, 37 (1935); L. van Itallie, A. J. Steenhauer, Arch. Pharm. 270, 313 (1932). Structure: A. Chatterjee, S. Bose, J. Indian Chem. Soc. 31, 17 (1954); F. A. L. Anet et al., J. Chem. Soc. 1954, 1242. Stereochemistry: M. F. Bartlett et al., J. Am. Chem. Soc. 84, 622 (1962). Synthesis: S. Masamune et al., ibid. 89, 2506 (1967); E. E. Van Tamelen, L. K. Oliver, ibid. 92, 2136 (1970); K. Mashimo, Y. Sato, Chem. Pharm. Bull. 18, 353 (1970). Physico-chemical properties: A. Petter, Arzneim.-Forsch. 24, 874 (1974). Antiarrhythmic activity: A. Petter, K. Engelmann, ibid. 876. Reviews: R. Robinson in Festschrift Arthur Stoll (Birkhäuser-Verlag, Basel, 1957) pp 457-467; A. Koskinen, M. Lounasmaa in Progress in the Chemistry of Natural Products vol. 43, W. Herz et al., Eds. (Springer-Verlag, New York, 1983) pp 268-346.

Serpentine (Alkaloid) CAS Registry Number: 18786-24-8 蛇纹石素

CAS Name: 3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19a-methyloxayohimbanium
Percent Composition: C 72.40%, H 5.79%, N 8.04%, O 13.78%
Literature References: From roots of Rauwolfia serpentina (L.) Benth., Apocynaceae: Schlittler, Schwarz, Helv. Chim. Acta 33, 1463 (1950). Structure: Schlittler et al., ibid. 37, 1912 (1954); Klohs et al., J. Am. Chem. Soc. 76, 1332 (1954); Wenkert, Roychaudhuri, ibid. 80, 1613 (1958). Stereoisomer of alstonine, q.v. Stereochemistry: Fritz, Ann. 655, 148 (1962); Shamma, Richey, J. Am. Chem. Soc. 85, 2507 (1963).

Baicalein CAS Registry Number: 491-67-8 黄芩素; 黄芩苷元

CAS Name: 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Additional Names: 5,6,7-trihydroxyflavone; noroxylin
Percent Composition: C 66.67%, H 3.73%, O 29.60%
Literature References: From roots of Scutellaria baicalensis. Isoln and structure: Bargellini, Gazz. Chim. Ital. 49, II, 47 (1919); Shibata et al., Acta Phytochim. 1, 109 (1923). Synthesis: Sastri, Seshadri, Proc. Indian Acad. Sci. 23A, 262 (1946), C.A. 41, 449 (1947); Schönberg et al., J. Am. Chem. Soc. 77, 5390 (1955); Jouanne, Mentzer, Compt. Rend. 254, 727 (1962); Agasimundin, Siddappa, J. Chem. Soc. Perkin Trans. 1 1973, 503. Pharmacology: Koda et al., C.A. 75, 47200d (1971).

Atisine CAS Registry Number: 466-43-3

Additional Names: Anthorine
Percent Composition: C 76.92%, H 9.68%, N 4.08%, O 9.32%
Literature References: From roots of the "atis" plant, Aconitum heterophyllum Wall., and from A. anthora L., Ranunculaceae: Broughton, Blue Book of East India Cinchona Cultivation 1877, 133; Goris, Metin, Compt. Rend. 180, 968 (1925); Lawson, Topps, J. Chem. Soc. 1937, 1640. Structure: Wiesner et al., Chem. Ind. (London) 1954, 132; Pelletier, Jacobs, J. Am. Chem. Soc. 76, 4496 (1954). Structure and stereochemistry: Dvornik, Edwards, Can. J. Chem. 42, 137 (1964). Partial synthesis: Pelletier, Jacobs, J. Am. Chem. Soc. 78, 4144 (1956); Pelletier, Parthasarathy, Tetrahedron Lett. 1963, 205. Racemic synthesis and resolution: Nagata et al., J. Am. Chem. Soc. 85, 2342 (1963); 89, 1499 (1967); Masamune, ibid. 86, 291 (1964); Guthrie et al., Tetrahedron Lett. 1966, 4645. 13C-NMR study of C-20 epimers: N. V. Mody, S. W. Pelletier, Tetrahedron 34, 2421 (1978).

Perezone CAS Registry Number: 3600-95-1 2-[(1R)-1,5-二甲基-4-己烯-1-基]-3-羟基-5-甲基-2,5-环己二烯-1,4-二酮

CAS Name: 2-[(1R)-1,5-Dimethyl-4-hexenyl]-3-hydroxy-5-methyl-2,5-cyclohexadiene-1,4-dione
Additional Names: 2-(1,5-dimethyl-4-hexenyl)-3-hydroxy-5-methyl-p-benzoquinone; pipitzahoic acid
Per...
Literature References: From roots of Trixis pipitzahuac Shaffner (Perezia adnata Gr., Compositae): Weld, Ann. 95, 188 (1855); from roots of Radix pereziae: Mylius, Ber. 18, 463, 480, 937 (1885); Anschütz, Ber. 18, 709 (1885); Fichter et al., Ann. 395, 1, 15 (1913). Structure: Archer, Thomson, Chem. Commun. 1965, 354; Bates et al., Chem. Ind. (London) 1965, 1793.

Vincetoxin CAS Registry Number: 1401-78-1

Additional Names: Cynanchin
Literature References: From roots of Vincetoxicum officinale Moench., Asclepiadaceae: Tanret, Compt. Rend. 100, 277 (1885); Kubler, Arch. Pharm. 246, 660 (1908); Gager, Zechner, ibid. 276, 431 (1938). Constitution: Korte, Ber. 88, 1527 (1955); Korte, Ripphahn, Ann. 621, 58 (1959). Known in two forms: water-soluble and water-insoluble.

Rubiadin CAS Registry Number: 117-02-2 甲基异茜草素

CAS Name: 1,3-Dihydroxy-2-methyl-9,10-anthracenedione
Additional Names: 1,3-dihydroxy-2-methylanthraquinone
Percent Composition: C 70.86%, H 3.96%, O 25.17%
Literature References: From Rubia tinctorum L., Coprosma var., Morinda citrifolia Linn, Rubiaceae: Schunck, Ann. 87, 344 (1853); Briggs, Nicholls, J. Chem. Soc. 1949, 1241; Briggs et al., ibid. 1952, 1718; Borvie, Cooke, Aust. J. Chem. 15, 332 (1962). Structure: Marchlewski, J. Chem. Soc. 63, 1137 (1893); Schunck, Marchlewski, ibid. 65, 182 (1894); Jones, Robertson, ibid. 1930, 1699. Synthesis: Joshi et al., J. Sci. Ind. Res. 14B, 87 (1955); Hirase, Chem. Pharm. Bull. 8, 417 (1960).