其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Limettin CAS Registry Number: 487-06-9 柠檬油素

CAS Name: 5,7-Dimethoxy-2H-1-benzopyran-2-one
Additional Names: 5,7-dimethoxycoumarin; citropten
Percent Composition: C 64.08%, H 4.89%, O 31.04%
Literature References: From rind of fruit of Citrus lima Lunan (C. limetta Auth.), Rutaceae (lime): Tilden, Beck, J. Chem. Soc. 57, 323 (1890); from W. Indian lime oil: Caldwell, Jones, ibid. 1945, 570; from citrus oils: Stanley, Vannier, US 2889337 (1959 to U.S.D.A.). Synthesis: Schmidt, Arch. Pharm. 242, 288 (1904); Heyes, Robertson, J. Chem. Soc. 1936, 1831.

Tetramethyldiaminobutane CAS Registry Number: 111-51-3 N,N,N',N'-四甲基-1,4-丁二胺

CAS Name: N,N,N',N'-Tetramethyl-1,4-butanediamine
Additional Names: N,N,N',N'-tetramethylputrescine
Percent Composition: C 66.61%, H 13.97%, N 19.42%
Literature References: From root and herb of Hyoscyamus reticulatus L. and H. muticus L., Solanaceae: Willstätter, Heuber, Ber. 40, 3869 (1907); Konowalowa, Magidson, Arch. Pharm. 266, 449 (1928). Synthesis: Lunsford et al., J. Org. Chem. 22, 1225 (1957); Solov'ev, Skoldinov, Zh. Obshch. Khim. 33, 1821 (1963), C.A. 59, 7360f (1963).

Nandinine CAS Registry Number: 572-76-9 10-甲氧基-5,8,13,13A-四氢-6H-[1,3]二氧杂环戊并[4,5-g]异喹啉并[3,2-A]异喹啉-9-醇

CAS Name: (13aS)-5,8,13,13a-Tetrahydro-10-methoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizin-9-ol
Additional Names: 10-methoxy-2,3-(methylenedioxy)berbin-9-ol; 5,6,13,13a-tetrahydro-9-hydrox...
Literature References: From root bark of Nandina domestica Thunb., Berberidaceae: Eijkman, Ber. 17, 441 (1884); Kitasato, J. Pharm. Soc. Jpn. 522, 1 (1925). Structure: idem, Acta Phytochim. 3, 175 (1927), C.A. 22, 1779 (1928); Späth, Leithe, Ber. 63, 3007 (1930). Configuration: Corrodi, Hardegger, Helv. Chim. Acta 39, 889 (1956). Synthesis: Kametani et al., J. Chem. Soc. C 1969, 2036; eidem, J. Chem. Soc. Perkin Trans. 1 1977, 1151.

Oroxylin A CAS Registry Number: 480-11-5 千层纸素A

CAS Name: 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one
Additional Names: 5,7-dihydroxy-6-methoxyflavone; oroxylin
Percent Composition: C 67.60%, H 4.26%, O 28.14%
Literature References: From root bark of Oroxylum indicum Vent., Bignoniaceae: Naylor, Chaplin, Pharm. J. 20, 257 (1890); Naylor, Dyer, J. Chem. Soc. 79, 954 (1901); Row et al., Proc. Indian Acad. Sci. 28A, 189 (1948). Structure: Shah et al., J. Chem. Soc. 1936, 591; 1938, 1555. Synthesis: Murti, Seshadri, Proc. Indian Acad. Sci. 29A, 1 (1949); Sarin, Seshadri, J. Sci. Ind. Res. 19B, 117 (1960); Molho, Gerphagnon, Bull. Soc. Chim. Fr. 1963, 607; Varady, Tetrahedron Lett. 1965, 4281.

Indaconitine CAS Registry Number: 4491-19-4 印乌头碱

CAS Name: 16-Ethyl-1,6,19-trimethoxy-4-(methoxymethyl)aconitane-3,8,10,11-tetrol 8-acetate 10-benzoate
Additional Names: acetylbenzoylpseudaconine
Percent Composition: C 64.85%, H 7.52%, N 2...
Literature References: From root of Aconitum chasmanthum Stapf. Ranunculaceae: Dunstan, Andrews, J. Chem. Soc. 87, 1620 (1905). Structure: Gilman, Marion, Can. J. Chem. 42, 2700 (1964).

Oxyacanthine CAS Registry Number: 548-40-3 尖刺檗鹼

CAS Name: 6,6',7-Trimethoxy-2,2'-dimethyloxyacanthan-12'-ol
Additional Names: vinetine
Percent Composition: C 73.00%, H 6.62%, N 4.60%, O 15.77%
Literature References: From root of Berberis vulgaris L., Berberidaceae: Rüdel, Arch. Pharm. 229, 631 (1891); Späth, Kolbe, Ber. 58, 2280 (1925). Structure: v. Bruchhausen et al., Ann. 507, 144 (1933); Fujita, J. Pharm. Soc. Jpn. 72, 213 (1952), C.A. 47, 6429b (1953).

Chelerythrine CAS Registry Number: 34316-15-9 白屈菜红碱

CAS Name: 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium
Additional Names: toddaline
Literature References: From root of Chelidonium majus L., Papaveraceae: Kratzmann, Pharm. Monatsh. 5, 161 (1924), C.A. 18, 34062 (1924); Platonova et al., J. Gen. Chem. USSR 26, 181 (1956). Structure: Späth, Kuffner, Ber. 64, 1123 (1931); N. Decaudain et al., Ann. Pharm. Fr. 35, 521 (1977). Identity with toddaline: Govindachari, Thyagarajan, J. Chem. Soc. 1956, 769. Synthesis of chelerythrine chloride: Bailey, Worthing, ibid. 4535; S. V. Kessar et al., J. Org. Chem. 53, 1708 (1988). Pharmacology: Chelombit'o, Murav'eva, Aktual. Probl. Farmakol. Farm. Vses. Nauchn. Konf. 1971, 183, C.A. 76, 112g (1972).

Homochelidonine CAS Registry Number: 476-33-5 β-高白屈菜碱

CAS Name: 4b,5,6,11b,12,13-Hexahydro-1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-5-ol
Additional Names: a-homochelidonine
Percent Composition: C 68.28%, H 6.28%, N 3.79%, O ...
Literature References: From root of Chelidonium majus L., Papaveraceae: Schmidt, Selle, Arch. Pharm. 228, 441 (1890). Structure: Späth, Kuffner, Ber. 64, 1123 (1931); H. W. Bersch, Arch. Pharm. 291, 491 (1958). Total synthesis: I. Ninomiya et al., Heterocycles 7, 137 (1977).

Insularine CAS Registry Number: 549-07-5

Percent Composition: C 73.53%, H 6.50%, N 4.51%, O 15.47%
Literature References: From root of Cissampelos insularis Makino and C. ochiaiana Yamamoto, Menispermaceae. Isoln: Kondo, Yano, J. Pharm. Soc. Jpn. 47, 815 (1927); Kondo, Tomita, Arch. Pharm. 274, 76 (1936). Structure: Tomita, Kikuchi, J. Pharm. Soc. Jpn. 77, 997 (1957).

Trilobine CAS Registry Number: 6138-73-4 三叶木防已碱

CAS Name: (1'a)-6',7-Epoxy-6,12'-dimethoxy-2'-methyloxyacanthan
Percent Composition: C 74.71%, H 6.09%, N 4.98%, O 14.22%
Literature References: From root of Cocculus trilobus DC. and C. sarmentosus Diels, Menispermaceae: Tomita et al., J. Pharm. Soc. Jpn. 48, 83 (1928); 50, 127 (1930); 62, 468, 481 (1942). Structure: Kondo, Tomita, Ann. 497, 104 (1932); Inubushi, Nomura, Tetrahedron Lett. 1962, 1133. Total synthesis of trilobine and isotrilobine: Y. Inubushi et al., Chem. Pharm. Bull. 25, 1636 (1977).