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Aminolevulinic Acid Hydrochloride–5 CAS# 5451-09-2 5-氨基乙酰丙酸盐酸盐
Aminolevulinic acid, also known as ALA, is a topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX ...
Shrestha-dawadi, Prativa Bade; Lugtenburg, Johan. Preparation of [1,2,3,4,5-13C5]-5-amino-4-oxopentanoic acid (ALA) - design of a synthetic scheme to prepare any 13C- and 15N-isotopomer with high isotopic enrichment. European Journal of Organic Chemistry. Issue 23. Pages 4654-4663. 2003.
Resmetirom CAS# 920509-32-6 2-(3,5-二氯-4-((5-异丙基-6-氧代-1,6-二氢哒嗪-3-基)氧基)苯基)-3,5-二氧基-2,3,4,5-四氢-1,2,4-三嗪-6-碳腈
Resmetirom, also known as MGL-3196, is a potent and highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. The beneficial effects of thyroid hormon...
Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of DyslipidemiaBy: Kelly, Martha J.; et alJournal of Medicinal Chemistry (2014), 57(10), 3912-3923
Artemether CAS# 71963-77-4 蒿甲醚
Artemether is a natural product which effectively kills both malarial parasites P. falciparum and P. vivax. Artemether is usually used in combination with Lumefantrine for the treatment of malaria. Ar...
Continuous synthesis of artemisinin-derived medicines; Gilmore, Kerry; Kopetzki, Daniel; Lee, Ju Weon; Horvath, Zoltan; McQuade, D. Tyler; Seidel-Morgenstern, Andreas; Seeberger, Peter H. Chemical Communications (Cambridge, United Kingdom); Volume 50; Issue 84; Pages 12652-12655; Journal; 2014
Amisulpride CAS# 71675-85-9 阿米舒必利
Amisulpride, a substituted benzamide derivative, demonstrated potent antidopaminergic activity in preclinical studies by selectively antagonizing dopamine D₂ and D₃ receptors with high affinity (Ki va...
Synthesis of AmisulprideBy:Cheng, Yuhong;Kang, Jiangpeng;Chen, Wei;Luo, Zhenfu;Sun, BoZhongguo Yiyao Gongye Zazhi (2011), 42(11), 801-803
Galangin CAS# 548-83-4 高良姜素; 3,5,7-三羟基黄酮
Galangin inhibits Ca2+ entry into TRPC5 expressing cells and also induces autophagy.
Lee, Jae In; Park, Se Bin. An effective synthesis of 3-methoxyflavones via 1-(2-hydroxyphenyl)-2-methoxy-3-phenyl-1,3-propanediones. Bulletin of the Korean Chemical Society. Volume 33. Issue 4. Pages 1379-1382. Journal. (2012).
Alitretinoin CAS# 5300-03-8 9-顺式视黄酸
Alitretinoin, or 9-cis-retinoic acid, is a form of vitamin A. Alitretinoin is an orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and e...
Suzuki, Masaaki; Takashima-Hirano, Misato; Ishii, Hideki; Watanabe, Chika; Sumi, Kengo; Koyama, Hiroko; Doi, Hisashi. Synthesis of 11C-labeled retinoic acid, [11C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C-[11C]methylation. Bioorganic & Medicinal Chemistry Letters. Volume 24. Issue 15. Pages 3622-3625. 2014.
Allithiamine CAS# 554-44-9 蒜硫胺
Allithiamine (thiamine allyl disulfide) is a lipid-soluble thiamine derivative with higher cellular uptake than thiamine. In vitro, it more efficiently increases intracellular thiamine diphosphate and...
Amifampridine CAS# 54-96-6 3,4-二氨基吡啶
Amifampridine is used as a drug, predominantly in the treatment of a number of rare muscle diseases. The phosphate salt of amifampridine is a more stable formulation that does not require refrigeratio...
Reference: Bakke, J. M.; Riha, J. Synthesis of 3,4-diaminopyridine and imidazo[4,5-c]pyridines by nitration of 4-(acylamino)pyridines. Journal of Heterocyclic Chemistry. Volume 36. Issue 5. Pages 1143-1145. Journal. (1999)
Nilotinib CAS# 641571-10-0 尼罗替尼
Nilotinib, also known as AMN107, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Structurally related to imatinib, it was d...
Ueda, Satoshi; Su, Mingjuan; Buchwald, Stephen L. Completely N1-selective palladium-catalyzed arylation of unsymmetric imidazoles: application to the synthesis of nilotinib. Journal of the American Chemical Society. Volume 134. Issue 1. Pages 700-706. 2012.
Fluoroestradiol F18 CAS# 94153-53-4
Fluoroestradiol F18 (16α-[18F]-fluoro-17β-estradiol, FES) is a radiolabeled estrogen analog developed as a positron emission tomography (PET) tracer for imaging estrogen receptor (ER) expression, prim...
Dixit M, Shi JF, Wei L, et al, Synthesis of clinical-grade [18F]-fluoroestradiol as a surrogate PET biomarker for the evaluation of estrogen receptor-targeting therapeutic drug. Int. J. Mol. Imag. 2013, 278607.
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