Amisulpride CAS# 71675-85-9 阿米舒必利

Amisulpride, a substituted benzamide derivative, demonstrated potent antidopaminergic activity in preclinical studies by selectively antagonizing dopamine D₂ and D₃ receptors with high affinity (Ki values ~2.8–3.2 nM for D₂, ~3.1 nM for D₃). Unlike typical antipsychotics, it showed minimal affinity for D₁, D₄, D₅, and serotonergic receptors, indicating receptor selectivity. In rodent models, amisulpride significantly reduced hyperlocomotion induced by psychostimulants, consistent with antipsychotic efficacy, while enhancing dopamine release in prefrontal cortex at low doses, suggesting potential procognitive effects. Importantly, preclinical toxicology showed a favorable safety margin, with fewer extrapyramidal symptoms compared to conventional antipsychotics at therapeutically relevant doses.