合成工艺路线中心备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目整合推广和市场调研服务, 请致函联系我们
数据库发展方向
1. 智能化融合：发展数据挖掘、集成、分析、可视化及人工智能工具，实现数据与文献、模型、计算等资源的有机融合，促进领域数智驱动科研新范式变革.
2. 标准化体系建设：以统一的数据标准管理体系为基础，系统整合全链条多源异构数据，聚焦高价值业务需求，精准构建结构合理、标注规范、语义清晰的数据资源.
3. 开放共享生态：开展数据提供方、使用方和服务方生态体系建设，实现多元主体间数据共享、共用、共治。.
4. 多模态数据处理：构建“全模态数据治理平台+高质量数据服务”一体化解决方案，提升非结构化数据处理能力.
客户展示
合成工艺路线中心
Ibrutinib CAS# 936563-96-1 依鲁替尼
Ibrutinib, also known as PCI-32765, is a potent and orally active BTK inhibitor. Ibrutinib binds to and inhibits BTK activity, preventing B-cell activation and B-cell-mediated signaling and inhibiting...
Li, Xixiang; Wang, Aoli; Yu, Kailin; Qi, Ziping; Chen, Cheng; Wang, Wenchao; Hu, Chen; Wu, Hong; Wu, Jiaxin; Zhao, Zheng; Liu, Juan; Zou, Fengming; Wang, Li; Wang, Beilei; Wang, Wei; Zhang, Shanchun; Liu, Jing; Liu, Qingsong. Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia. Journal of Medicinal Chemistry. Volume 58. Issue 24. Pages 9625-9638. Journal; Online Computer File. (2015).
Tucatinib CAS# 937263-43-9 图卡蒂尼(伊尔比尼替尼,ONT-380)
Tucatinib is a highly selective HER2 tyrosine kinase inhibitor that exhibits strong antiproliferative activity in HER2-positive cancer cell lines, including BT-474 and SK-BR-3, with IC₅₀ values in the...
Synthesis and in vivo evaluation of [11C]tucatinib for HER2-targeted PET imagingBy: Muller, Marius; et alBioorganic & Medicinal Chemistry Letters (2023), 80, 129088
Pacritinib CAS# 937272-79-2 帕西替尼(SB1518)
Pacritinib (SB1518) is an orally bioavailable multikinase inhibitor with selectivity for JAK2 and FLT3. In preclinical enzymatic assays, it inhibited JAK2 with an IC50 of ~23 nM and FLT3 with an IC50 ...
Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and LymphomaBy: William, Anthony D.; et alJournal of Medicinal Chemistry (2011), 54(13), 4638-4658
Macimorelin Acetate CAS# 945212-59-9 醋酸马西瑞林
Macimorelin Acetate is a ghrelin receptor agonist which exerts an anticonvulsant effect.
Chen, Yonghan; Liu, Jian; Ma, Yaping; Yuan, Jiancheng. Process for preparation of macimorelin by solid phase peptide synthesis method. CN 105330720. (Assignee Hybio Pharmaceutical Co., Ltd., Peop. Rep. China)
Avutometinib CAS# 946128-88-7 RO5126766(CH5126766)抑制剂
Avutometinib, also known as RO5126766 and CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Raf/M...
Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen ScanningBy: Aoki, Toshihiro; et alACS Medicinal Chemistry Letters (2014), 5(4), 309-314
Quizartinib CAS# 950769-58-1 奎扎替尼
Quizartinib (AC220) is a potent, selective FLT3 inhibitor with sub-nanomolar biochemical potency (FLT3 ITD IC₅₀ ≈ 1–2 nM) and >10-fold selectivity over most kinases. In FLT3-ITD–positive AML cell line...
Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) InhibitorBy: Chao, Qi; et alJournal of Medicinal Chemistry (2009), 52(23), 7808-7816
Doxecitine CAS# 951-77-9 2’-脱氧胞苷
Doxecitine (also known as SR-13668) is an orally bioavailable PI3K/Akt inhibitor. In vitro, it suppresses proliferation of a broad range of human tumor cell lines (colon, breast, prostate) with GI50 v...
Gosselin G, Imbach JL, Bryant ML. β-L-2'-deoxy-nucleosides for the treatment of hepatitis B.US20100152126 (2010).
Florbetapir F-18 CAS# 956103-76-7 氟贝他吡[18F]
Florbetapir F-18 is a PET agent for Abeta plaques.
Liu, Yajing; Zhu, Lin; Ploessl, Karl; Choi, Seok Rye; Qiao, Hongwen; Sun, Xiaotao; Li, Song; Zha, Zhihao; Kung, Hank F. Optimization of automated radiosynthesis of [18F]AV-45: a new PET imaging agent for Alzheimer's disease. Nuclear Medicine and Biology. Volume 37. Issue 8. Pages 917-925. Journal. (2010).
Apalutamide CAS# 956104-40-8 阿帕他胺
Apalutamide, also known as ARN-509 and JNJ-56021927 , is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induc...
Pang, Xuehai; Wang, Yingwei; Chen, Yuanwei. Design, synthesis, and biological evaluation of deuterated apalutamide with improved pharmacokinetic profiles. Bioorganic & Medicinal Chemistry Letters. Volume 27. Issue 12. Pages 2803-2806. Journal; Online Computer File. (2017).
Sonidegib CAS# 956697-53-3 雷特格韦
Sonidegib, also known as, erismodegib, LDE225, NVP-LDE225, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Erismodegib selectively binds to...
Reference: Wang, Deyin; Xu, Xin; Qi, Yuxin; Wang, Baolin; Zhang, Wei; Zhao, Yinlong. Preparation of Sonidegib and intermediate thereof. CN 109293649. (Xinfa Pharmaceutical Co., Ltd., Peop. Rep. China)
我们的宗旨: 净化, 简洁, 高效Purifying, concise, efficient !我们的口号: 减少中间商赚差价!
即日起可免费注册成为会员, 建立企业产品库, 免费上传产品目录, 企业介绍等. 让你的产品直接呈现给客户.
试运营阶段,所有广告业务5折优惠
分类广告投放
依据化学成分的不同, 针对不同的企业和产品, 我们提供分类产品广告投放.客户展示
优秀企业推荐
