Tucatinib CAS# 937263-43-9 图卡蒂尼(伊尔比尼替尼,ONT-380)

Tucatinib is a highly selective HER2 tyrosine kinase inhibitor that exhibits strong antiproliferative activity in HER2-positive cancer cell lines, including BT-474 and SK-BR-3, with IC₅₀ values in the low nanomolar range. In xenograft mouse models of HER2-amplified breast cancer, tucatinib significantly reduces tumor volume and enhances survival, especially when combined with trastuzumab or capecitabine. It also shows brain-penetrant properties, demonstrating efficacy against HER2-positive brain metastases in preclinical models.