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Meropenem CAS# 96036-03-2 美罗培南
Meropenem is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup of carbapenem...
Reference: Nadenik, Peter; Storm, Ole; Kremminger, Peter. Meropenem intermediate in crystalline form. WO 2005118586. (Assignee Sandoz AG, Switz)
Daprodustat CAS# 960539-70-2 达普司他
Daprodustat, also known as GSK1278863, is a novel HIF-prolyl hydroxylase inhibitor. Hypoxia inducible factor (HIF) stabilization by HIF-prolyl hydroxylase (PHD) inhibitors may improve ischemic condit...
Novel and Cost-Effective Manufacturing Process Development of DaprodustatBy: Manda, Amarendhar; et alOrganic Process Research & Development (2025), 29(3), 953-963
Estradiol valerate CAS# 979-32-8 戊酸雌二醇
Estradiol valerate is a synthetic ester, specifically the 17-pentanoyl ester, of the natural estrogen, 17β-estradiol. It was introduced in the 1950s, and along with estradiol benzoate and estradiol cypionate, has since become one of the most widely used esters of estradiol. (Source: http://en.wikipedia.org/wiki/Estradiol_valerate).
Rotigotine CAS# 99755-59-6 罗替高汀
Rotigotine is a non-selective dopamine receptor agonist with preference for D3 receptors over D2 and D1. As such, it is an effective anti-Parkinsonian agent. Racemic rotigotine is about 50 times as po...
Webster, Robert; Boyer, Alistair; Fleming, Matthew J.; Lautens, Mark. Practical Asymmetric Synthesis of Bioactive Aminotetralins from a Racemic Precursor Using a Regiodivergent Resolution. Organic Letters. Volume 12. Issue 23. Pages 5418-5421. 2010.
Adibelivir CAS# 2305750-23-4
Adibelivir [IM-250] is a potent HSV-1 helicase primase inhibitor. Therapy of primary HSV infections with IM-250 not only reduces the duration of disease symptoms or time to healing but also prevents ...
Patent#: WO2019068817
Aficamten CAS# 2364554-48-1
Aficamten (CK-274) is a selective, reversible cardiac myosin inhibitor developed for hypertrophic cardiomyopathy (HCM). In vitro, aficamten inhibits human β-cardiac myosin ATPase activity with low-nan...
Chuang, Chihyuan ; Collibee, Scott ; Ashcraft, Luke; Wang, Wenyue; Vander Wal, Mark; Wang, Xiaolin; Hwee, Darren T.; Wu, Yangsong; Wang, Jingying; Chin, Eva R.; Cremin, Peadar; Zamora, Jeanelle; Hartman, James; Schaletzky, Julia; Wehri, Eddie; Robertson, Laura A.; Malik, Fady I.; Morgan, Bradley P. Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. Journal of Medicinal Chemistry (2021), 64(19), 14142-14152.
Gadopiclenol CAS# 311772-46-0
Gadopiclenol is a next-generation, macrocyclic, gadolinium-based contrast agent (GBCA) with high relaxivity designed for MRI imaging. In preclinical studies, it exhibited approximately twice the r1 re...
Gadolinium bearing pcta-based contrast agentsInventors: Napolitano, Roberta; et alWorld Intellectual Property OrganizationPatent Number# WO2020030618
Telavancin CAS# 372151-71-8 特拉万星
Telavancin a semisynthetic lipoglycopeptide vancomycin-derivative and antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-...
Leadbetter, Michael R.; Adams, Stacy M.; Bazzini, Bettina; Fatheree, Paul R.; Karr, Dane E.; Krause, Kevin M.; Lam, Bernice M. T.; Linsell, Martin S.; Nodwell, Matthew B.; Pace, John L.; Quast, Kelly; Shaw, Jeng-Pyng; Soriano, Elizabeth; Trapp, Sean G.; Villena, Jenny D.; Wu, Terry X.; Christensen, Burton G.; Judice, J. Kevin. Hydrophobic vancomycin derivatives with improved ADME properties: Discovery of telavancin (TD-6424). Journal of Antibiotics. Volume 57. Issue 5. Pages 326-336. 2004.
Doxribtimine CAS# 50-89-5 beta-胸苷
Doxribtimine (JBI-778) shows sub-micromolar inhibitory activity against PRMT5 in biochemical assays (IC50 ~5–15 nM) and potently suppresses PRMT5-dependent symmetric dimethyl-arginine (SDMA) in cell s...
Development of hydrophilic photolabile hydroxyl protecting groupsBy: Yang, Haishen; et alPhotochemical & Photobiological Sciences (2012), 11(3), 514-517
Adrenochrome CAS# 54-06-8 肾上腺色素
Adrenochrome is an oxidation product of epinephrine (adrenaline), and although it has been studied for decades, its bioactivity remains poorly characterized and controversial. Early research suggested...
Amyloid Peptide Nanofibrils Promote Efficient Neurotransmitter Oxidation and Serve as Scaffolds for Melanin ProductionBy: Kim, Inhye; et alAngewandte Chemie, International Edition (2025), 64(44), e202510234
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