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Dabigatran etexilate mesylate CAS# 872728-81-9 甲磺酸达比加群酯
Dabigatran etexilate, also known as BIBR 1048MS, is a direct thrombin inhibitor. Dabigatran is used to prevent strokes in those with atrial fibrillation not caused by heart valve issues, as well as de...
Devarasetty, Sitaramaiah; Janni, Ravi; Nunna, Rambabu; Suraparaju, Raghu Ram. An improved process for the preparation of Dabigatran Etexilate mesylate and synthesis of its impurities. Pharma Chemica. Volume 10. Issue 4. Pages 127-148. Journal; Online Computer File. (2018).
Ivacaftor CAS# 873054-44-5 依伐卡托
Ivacaftor, also known as VX-770, is a drug used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 4–5% c...
Reference: Zhang, Rui; Han, Guanyu; Jiang, Luobin; Shen, Yao; Yang, Rui; Mao, Yongjun; Wang, Hang. An Efficient Synthesis of Ivacaftor. Journal of Heterocyclic Chemistry. Volume 54. Issue 6. Pages 3169-3173. Journal; Online Computer File. (2017).
Crizotinib CAS# 877399-52-5 克唑替尼
Crizotinib, also known as PF-02341066, is an orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic...
Cui, J. Jean; Tran-Dube, Michelle; Shen, Hong; Nambu, Mitchell; Kung, Pei-Pei; Pairish, Mason; Jia, Lei; Meng, Jerry; Funk, Lee; Botrous, Iriny; McTigue, Michele; Grodsky, Neil; Ryan, Kevin; Padrique, Ellen; Alton, Gordon; Timofeevski, Sergei; Yamazaki, Shinji; Li, Qiuhua; Zou, Helen; Christensen, James; Mroczkowski, Barbara; Bender, Steve; Kania, Robert S.; Edwards, Martin P. Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK). Journal of Medicinal Chemistry. Volume 54. Issue 18. Pages 6342-6363. Journal; Online Computer File. (2011).
Artesunate CAS# 88495-63-0 青蒿琥酯; 青蒿脂
Artesunate, a semisynthetic derivative of artemisinin, has demonstrated broad preclinical bioactivity against malaria and cancer. In murine Plasmodium berghei models, artesunate reduced parasitemia by...
Continuous synthesis of artemisinin-derived medicinesBy: Gilmore, Kerry; et alChemical Communications (Cambridge, United Kingdom) (2014), 50(84), 12652-12655
Edaravone CAS# 89-25-8 依达拉奉
Edaravone, also known as Radicut and MCI-186, is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke. Edaravone exerts neuroprot...
MacLean, Mark A.; Diez-Cecilia, Elena; Lavery, Christopher B.; Reed, Mark A.; Wang, Yanfei; Weaver, Donald F.; Stradiotto, Mark. Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid. Bioorganic & Medicinal Chemistry Letters. Department of Chemistry. Dalhousie University. Halifax, Can. B3H 4R2. Volume 26. Issue 1. Pages 100-104. 2016.
Trifarotene CAS# 895542-09-3 曲法罗汀
Trifarotene is a gamma retinoic acid receptor agonist. Trifarotene is in development as a topical cream for the treatment of skin disorders, including acne vulgaris, cutaneous t-cell lymphoma and lame...
Reference: Biadatti, Thibaud; Dumais, Laurence; Soulet, Catherine; Talano, Sandrine; Daver, Sebastien. Preparation of [1,1':3',1'']terphenyl-4-carboxylic acid and esters a novel ligands modulating retinoic acid receptors (RAR), and use thereof in human medicine and in cosmetics. Assignee Galderma Research & Development, S.N.C., Fr. WO 2006066978. (2016).
Tirbanibulin CAS# 897016-82-9 5-[4-[2-(4-吗啉基)乙氧基]苯基]-N-(苯基甲基)-2-吡啶乙酰胺
Tirbanibulin (KX2-391 or KXB-964) is a synthetic, dual-action inhibitor of Src kinase signaling and tubulin polymerization. In preclinical biochemical assays, it inhibited Src kinase activity with an ...
Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)By: Smolinski, Michael P.; et alJournal of Medicinal Chemistry (2018), 61(11), 4704-4719
Fostamatinib CAS# 901119-35-5 福他替尼
Fostamatinib, also known as R 788 and R-935788, is an orally active, potent and selective Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. Fostamatinib is also a ...
Felfer, Ulfried; Giselbrecht, Karl-Heinz; Wolberg, Michael. Synthesis of N4-(2,2-dimethyl-4-[(dihydrogen phosphonoxy)-3-oxo-5-pyrido[1,4]oxazin-6-yl]-5-fluoro-N2-(3,4,5-trimethoxyphenyl))-2,4-pyrimidinediamine disodium salt. Assignee Rigel Pharmaceuticals, Inc., USA. WO 2011002999. (2011).
Crisaborole CAS# 906673-24-3 克立硼罗
Crisaborole, also known as AN-2728, is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 a...
Reference: Akama T, Baker SJ, Zhang YK, Hernandez V, Zhou H, Sanders V, Freund Y, Kimura R, Maples KR, Plattner JJ. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32. doi: 10.1016/j.bmcl.2009.03.007. Epub 2009 Mar 9. PubMed PMID: 19303290.
Semaglutide CAS# 910463-68-2 索玛鲁肽
Semaglutide, Long-acting human GLP-1 analog. Semaglutide seems to be more effective the other GLP-1Ras.
Reference: Ji Shengli. Method for preparing semaglutide by solid-liquid combination. CN 108059666. (Faming Zhuanli Shenqing (2018))
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